Tuesday, June 25

Day 1: Tuesday, June 25

8:00 AM – 7:30 PM | Registration Desk Open

The registration desk will be located in the Atrium on the Fourth Floor of the Seattle Convention Center Arch Building.

8:00 AM – 6:00 PM | Speaker Ready Room Open

Location: Room 613

Speakers should check-in at the speaker ready room at least 2 hours prior to their session start time. Staff will be on hand to answer questions about av setup in presentation rooms and assist with any presentation edits.

10:00 AM – 11:30 AM | Scientific Concurrent Session 1
Biofabrication as a Method for Development and Implementation of Clinically Useful Products

Chairs: Kimberlee Potter & Richard McFarland
SYIS Co-Chair: Pierpaolo Fucile
Location: Ballroom 6E
Session Topic: Biofabrication
Description: The session “Biofabrication as a Method for Development and Implementation of Clinically Useful Products” is aimed at showcasing tissue engineering, product development, and clinical application within health care systems adopting biofabrication. The goal of this session is to present the current developments in the field to advance the decentralized personalized medicine at the point of care, for the benefit of patients worldwide. This Symposium is thought to be useful to researchers, clinicians, or industry partners involved in planning, development or marketing of medical solutions made by tissue engineering or biofabrication methods, intended to be implemented in the clinical site. Any person at any role in the product development pipeline (from early idea stage to regulatory market strategy) should benefit from attending. The session will prioritize topics such as: product development for clinical solutions, scaling-up in manufacturing of personalized products, required regulation or standardization for biofabrication, new technology adoption, collaborative projects, and socially underrepresented patient’s benefit.

Keynote Speaker:
10:00 AM – 10:30 AM | Point of Care Medical Biofabrication
Beth Ripley, MD, PhD

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 1 – Biomanufacturing a Clinical Tissue Product at the Point of Care
Angiogenesis And Enhance Bone Regeneration
Presenting Author: James Hoying

10:45 AM – 11:00 AM | 2- 3d Bioprinted Vascularized Bone Grafts In Dynamic Culture Trigger Synergistic Effects Between Osteogenesis And Angiogenesis And Enhance Bone Regeneration
Presenting Author: Maria Chatzinikolaidou

11:15 AM – 11:30 AM | 4 – 3d Printed Scaffolds Incorporating Red Blood Cells-derived Extracellular Vesicles For Microrna Delivery To Treat Spinal Cord Injuries
Presenting Author: Chongquan Huang

3D In Vitro Tissue-engineered Tumor Modelling

Chairs: Rui Reis & Subhas Kundu
SYIS Co-Chair: Sheth Maulee
Location: Room 608/609
Session Topic: Cancer
Description: Researchers in regenerative medicine, cell and molecular biology, drug screening, and tissue engineering will get an opportunity to learn about the current methodologies and technologies for developing and using biomaterial-based matrices for 3D cellular and cancer disease models. The session will discuss realistic 3D in vitro tumour models for anticancer therapeutic screening and models for disease microenvironment dynamics, including cell migration and metastasis, to study and manipulate cancer and other diseases. Advanced strategies in 3D bioprinting using bio-ink, micro-patterning, and microfluidic devices allow us to investigate in-depth tumour cell invasion, intravasation, extravasation and tissue growth in the 3D microenvironment. Therefore, organizing a session discussing the state-of-art emerging technologies to research cancer and innovative treatments deeper using in vitro models is the demand of the current edge and practical uses for cancer therapies. This symposium will also invite researchers using the latest techniques to fabricate 3D scaffolds and hydrogels using different biomaterials, cancer cells and cancer-associated fibroblasts, and 3D cancer cell culture to create disease models. These innovative approaches to cancer theranostics, mechanism of action, current stage of development, and potential advantages and limitations will provide insights into the next steps of research.

Keynote Speaker:
10:00 AM – 10:30 AM | Engineering the interactions of cancer and vascularized bone with nanometer-scale precision on-a-chip
Luiz Bertassoni, PhD

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 5 – Matrix Stiffness Drives Piezo-1 Activation In Three-dimensional Head And Neck Cancer Spheroids And Derived Small Extracellular Vesicles
Presenting Author: Maulee Sheth

10:45 AM – 11:00 AM | 6 – 3D Collagen-based Scaffolds For The Investigation Of Extracellular Matrix Changes On Breast Cancer Progression, Chemotherapeutic Response And Gene Therapy In Breast Cancer
Presenting Author: Elizabeth Sainsbury

11:00 AM – 11:15 AM | 7 – Perivascular Mural Cells Regulate Vascular Function In Fibrotic Environment On-a-chip
Presenting Author: Cristiane M. Franca

11:15 AM – 11:30 AM | 8 – Extracellular Matrix In The Tumor Microenvironment And Its Influence On Cancer
Presenting Author: Astgik Petrosyan

Smart Biomaterials for Immunomodulation and Tissue Regeneration

Chairs: Kelvin Yeung
SYIS Co-Chair: Gabriele Nasello
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: Inflammation control is one of most fundamental parts in biomaterial-based tissue engineering. This is due to the nature of biomaterials as alien objects when recognized by the host immune system and inevitably trigger inflammation. An inflammatory microenvironment around the biomaterial is detrimental for tissue regeneration by hindering tissue cell differentiation and maturation. Ideally, a tissue engineering biomaterial is expected to modulate the local immune environment into the one beneficial for tissue regeneration. This can be achieved by using drug delivery systems to release anti-inflammatory chemicals/biomolecules, however, due to the difference between individuals (e.g., age, gender, and disease conditions such as obesity, diabetes, cancer, immune deficiency, etc.), the basal level of inflammation/immune cell activation varies among individuals, which making it difficult to optimize the drug-loading amount and release timing for each patient. To solve this problem to achieve a personalized immune modulation, recent advances in nanotechnology have endowed drug delivery systems with the capacity of environmental-responsive drug release. Such a “smart material” can sense the levels of inflammatory factors/changes (e.g., pH value, reactive oxidative species, cytokines, surface markers, etc.) and release certain amount of anti-inflammatory factors in response to different inflammatory levels, therefore ensures a personalized immune modulation to optimize the local environment for tissue regeneration. Hence, this proposed symposium aims to summarize the cutting-edge technologies on smart biomaterial design/development for personalized immunomodulation and inflammation control. The program will include 1-2 keynote speakers and 3-4 speakers to discuss the latest advances in this area, which is expected to attract audiences such as scholars in the fields of tissue engineering, regenerative medicine, immunology, material science, clinical practitioners, and biomedical industry partners. It will provide an excellent platform to discuss future strategies for tissue engineering biomaterial development and translation, which is relevant to the conference main topic (biomaterials for the future of healthcare).

Keynote Speaker:
10:00 AM – 10:30 AM
Jennifer Elisseeff

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 9 – Engineered Lung Microtissues To Model Macrophage Mechano-activation In Pulmonary Fibrosis And Anti-fibrosis Therapies
Presenting Author: Ruogang Zhao

10:45 AM – 11:00 AM | 10 – Matrix-bound Nanovesicles As Epigenetic Modulators Of The Myeloid Cell Phenotype
Presenting Author: Hector Capella-Monsonis,

11:00 AM – 11:15 AM | 11 – Remote Mechano Activation Of T Cell Receptors For Cell Therapies
Presenting Author: Alicia J. El Haj

11:15 AM – 11:30 AM | 12 – Electrospun Fiber Surface Roughness Modulates Macrophage Polarization: Implications For Fibrous Connective Tissue Injury Regeneration
Presenting Author: Aidan Alemifar

Advances and Challenges of Tendon and Ligament Engineering and Regeneration

Chairs: Manuela Gomes & Nathaniel Dyment
SYIS Co-Chair: Kannan Govindaraj
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description: Tendon injuries are among the most common musculoskeletal diseases, which can lead to significant functional impairments. Recent advances in tendon regeneration and engineering have shown promising results in improving healing outcomes and restoring tendon functionality. However, challenges persist in achieving optimal tendon regeneration. The complex hierarchical structure of tendons, with aligned collagen fibers and tendon-to-bone integration, remains difficult to replicate. Additionally, the mechanical properties and functionality of engineered tendons often fall short compared to native tissues. Importantly, the complex cellular and molecular mechanisms of tendon healing are far from being completely understood. Addressing these challenges requires interdisciplinary collaborations among scientists, engineers, and clinicians. This session aims at providing new insights and discuss the most recent advances on biomaterials design, cellular therapies, and tissue engineering techniques to overcome these hurdles and enable successful tendon regeneration and functional recovery.

Keynote Speaker:
10:00 AM – 10:30 AM | Tuned Tensions: The Art and Science of Tendon Mechanobiology and Repair
Jess Snedeker, PhD

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 13 – Development Of A Biomimetic Adhesive And Sturdy Janus Patch Exhibiting Anti-oxidative, Anti-inflammatory And Anti-bacterial Properties For Tendon Repair
Presenting Author: Shuai Zhao

10:45 AM – 11:00 AM | 14 – Tailor-made Nanoswitches For Studying Piezo1-mediated Mechanotransduction And Modulation Of Stem Cell Fate
Presenting Author: Rui Domingues

11:00 AM – 11:15 AM | 15 – Adaptive Cyclic Load That Changes As Collagen Organization Increases, Does Not Improve Maturation In Engineered Ligaments
Presenting Author: Leia D. Troop

11:15 AM – 11:30 AM | 16 – Metabolic Profiling Of Tendon And Cartilage Healing
Presenting Author: Iris Gerner

Bioassembly for Tissue Engineering and Biofabrication

Chairs: Gabriella Lindberg
Location: Room 618/619/620
Session Topic: Organoids, Bioreactors & Organ-on-Chip
Description: Bioassembly has recently been regarded as a critical alternative biofabrication technical route to bioprinting by the International Society of Biofabrication, as it enables the manipulation of millions of live cells to form spatially defined multicellular structures with close intercellular proximity. The close intercellular proximity can improve contact-dependent cell communication and promote the emergence of tissue-specific functions. Various bioassembly techniques have been demonstrated by exploring the interactions between cells/spheroids and physical fields, such as acoustic, optical, and magnetic fields. Compared to bioprinting, bioassembly takes advantage of high tunability, biocompatibility, and efficiency. Thus, bioassembly has been increasingly used to generate functional tissues from primary and hPSC-derived cells. In this section, we will present recent advances in bioassembly and discuss the future direction of bioassembly to construct high-fidelity and transplantable human tissue substitutes.

Oral Abstract Presentations:
10:00 AM – 10:15 AM | 17 – Acoustic Holographic Bioassembly for Tissue Engineering
Presenting Author: Dimitris Missirlis

10:15 AM – 10:30 AM | 18 – Multifrequency-driven Faraday Wave Bioassembly For Constructing Multiscale Cytoarchitecture
Presenting Author: Xinli Zheng

10:30 AM – 10:45 AM | 19 – Rapid Assembly Of Aligned Microvascular Networks For Cardiac Tissue Grafts
Presenting Author: Maggie Jewett

10:45 AM – 11:00 AM | 20 – Towards Clinically Relevant Cartilage Repair: Oxygen Control, Tissue Integration And Immunomodulation
Presenting Author: Gabriella Lindberg

11:00 AM – 11:15 AM | 21 – Construction Of A Hydrogel Based, 3d Bioprinted Corneal Stroma
Presenting Author: Deniz Basoz

11:15 AM – 11:30 AM | 22 – All-in-one Generation And Multiomic Profiling Of Human Whole Brain Organoid On A Microfluidic Plate
Presenting Author: Wen Zhao

Decellularized ECM materials for TERM

Chairs: Lisa White & Anna Blocki
SYIS Co-Chair: Thanusha Av
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: This session will encompass decellularized extracellular matrices, derived from different tissues and cell populations and their diverse and wide ranging applications in TERM. The keynote will be provided by Professor Stephen Badylak, pioneer of ECM biologic scaffolds, who will provide a valuable commentary on development and clinical applications of decellularized ECM materials.

Keynote Speaker:
10:00 AM – 10:30 AM | The Extracellular Matrix: An Inductive Bioscaffold for Functional Tissue Reconstruction
Stephen Badylak, DVM, PhD, MD

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 23 – The Pro-regenerative Extracellular Matrix Scaffold Microenvironment Enhances Cancer Vaccine Efficacy To Induce Anti-tumor Immune Memory
Presenting Author: Sanjay Pal

10:45 AM – 11:00 AM | 24 – Topographical Nanopatterning Of Decellularized Skeletal Muscle Extracellular Matrix For Muscle Regeneration
Presenting Author: Yong H. Tan

11:00 AM – 11:15 AM | 25 – Matrix Bound Nanovesicles Isolated From Immuno-Regulatory Tissue Have Distinct Biologic Functions
Presenting Author: Charles J. Patterson

11:15 AM – 11:30 AM | Suspension Electrospinning Of Decellularized Extracellular Matrix: A New Approach To Retain Bioactivity
Presenting Author: Sarah Jones

Sex, Age and Ancestral Determinants in TERM Research

Chairs: Mykel Green
SYIS Co-Chair: Sreypich Say
Location: Room 611/612
Session Topic: Sex, Age and Ancestral Determinants in TERM Research
Description: As the demand for precision medicine continues to rise, the “one size fits all” approach to the design of tissue engineered devices to treat diseases and injuries is becoming increasingly outdated. Tissue engineered devices have significant potential for transforming precision medicine, and individual patient complexity often necessitates integrating multiple functions into a single device to successfully customize therapies. In this session, we seek to highlight the latest research in tissue engineering technologies that enable prueba evaluation of sex, age, and ancestry as biological variables, including implantable devices for the real-time analysis of a patient’s condition or customized devices and material chemistries that adapt to a specific patient’s biology.

Oral Abstract Presentations:
10:00 AM – 10:15 AM | 27 – The Effect Of Estrogen-mimetic Compounds In Cell Culture On Human Mesenchymal Stromal Cell (hmsc)
Presenting Author: John. C. Bradford

10:15 AM – 10:30 AM | 28 – The Role Of Biological Sex In The Functionality Of Callus Organoids Using Integrated Transcriptome And Secretome Technologies
Presenting Author: Isaak Decoene

10:30 AM – 10:45 AM | 29 – Single Nucleus Rnaseq And Spatial Transcriptomics Delineate The Sex Specific Pro-reparative Effects Of An Infusible Extracellular Matrix For Myocardial Infarction Treatment
Presenting Author: Joshua Mesfin

10:45 AM – 11:00 AM | 30 – Matrix Mechanics Regulates Endothelial Cell Senescence
Presenting Author: Jiyeon Song

11:00 AM – 11:15 AM | 31 – Synergistic And Cell-specific Extracellular Vesicle Delivery Ofdevelopmental Transcription Factors To Human Intervertebral Disc Cells
Presenting Author: Khady Diop

11:15 AM – 11:30 AM | 32 – A Novel PEG-Based Injectable Macroporous Hydrogel Scaffold
Presenting Author: Mary E. Dickenson

Advances in Skin Tissue Engineering

Chairs: Erbil Abaci & Helena Zomer
SYIS Co-Chair: Luca Melotti
Location: Room 606/607
Session Topic: Skin Regeneration, Wound Healing, and Inflammation
Description: This session will bring the latest research on biomechanical mechanisms and fibrosis in skin tissue engineering.

Keynote Speaker:
10:00 AM – 10:30 AM
Geoffrey Gurtner

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 33 – Fibroblast-selective Inhibition of Mechanotransduction In A Biomechanically-relevant 3D Skin Model Of Fibrosis
Presenting Author: Alberto Pappalardo

10:45 AM – 11:00 AM | 34 – Macrophages And T Cells Enhance Tissue Complexity And Function In 3D Skin-like Tissue Models Of Fibrosis
Presenting Author: Isha Singh

11:00 AM – 11:15 AM | 35 – Biofabrication Of An Immunocompetent 3D Skin Tissue Equivalent Incorporating Primary Human Macrophages As A Pre-clinical Testing Platform For Inflammatory Skin Diseases
Presenting Author: Yi Wei Lim

11:15 AM – 11:30 AM | 36 – Tropoelastin Modulates Immune Responses To Accelerate Cutaneous Wound Healing
Presenting Author: Ziyu Wang

SYIS Special Panel: Navigating Career Challenges: Industry vs. Academia in Biomedical Engineering as an International Professional

Chairs: Mickael Dang, Sargol Okhovatian & Ziyu Wang
Location: Room 602/603/604
Session Topic: Special Session
Description: This panel will provide valuable insights and guidance to international professionals in the field of biomedical engineering, addressing the unique challenges they face when pursuing careers in industry or academia abroad. Esteemed experts from both sectors will share their experiences, discuss potential hurdles, and offer strategies for success, empowering attendees to make informed career decisions and foster professional growth.

RAPID FIRE: Next Generation Biomaterials in TERM – Session II

Chairs: Maryam Tilton
Location:
Room 615/616/617
Session Topic:
Rapid Fire

Rapid Fire Presentations:
10:00 AM – 10:05 AM | 37 – Advanced Glycation End-products As Mediators Of The Aberrant Crosslinking Of Extracellular Matrix In Scarred Liver Tissue
Presenting Author: Wenyu Kong

10:05 AM – 10:10 AM | 38 – Promoting Architectural Integrity In A Biocompatible 3d-Printed Nipple-Areola Complex For Post-Mastectomy Nipple Reconstruction
Presenting Author: Amal Shabazz

10:10 AM – 10:15 AM | 39 – In Vivo Remodeling Of Decellularized Bovine Tendon 52 Weeks Post-ovine Anterior Cruciate Ligament Reconstruction
Presenting Author: Shinya Imai

10:15 AM – 10:20 AM | 40 – A High-throughput 3d-printed Platform For In Vivo Screening Of Bioink Materials And Cell Formulations
Presenting Author: Fan Zhang

10:20 AM – 10:25 AM | 41 – Bioprinting Spray-on-Skin<sup>Tm</sup> For Full-thickness Wound Treatment At Point Of Care
Presenting Author: Eileen Wallace

10:30 AM – 10:35 AM | 42 – Interrogating The Impact Of Geometric Features On Host Responses To Porous Scaffolds
Presenting Author: Cherie Stabler

10:35 AM – 10:40 AM | 43 – Development Of Tissue-specific, Matrix Informed, 3d Models For Evaluation Of Treatment Resistance In Urological Cancers
Presenting Author: Olwyn Mahon

10:40 AM – 10:45 AM | 44 – Comparison Of Retinal Degeneration Treatment With Several Types Of Stem Cells And RPE Cells In A Rat Retinal Degeneration Model
Presenting Author: Qian Liu

10:45 AM – 10:50 AM | 45 – Investigating Impacts Of Surface Conjugated Poly(ethylene) Glycol On Pancreatic Islets To Investigate Changes In T Cell Migration Within A 3D Co-culture System
Presenting Author: Damea Pham

10:50 AM – 10:55 AM | 46 – In Vivo Evaluation Of A Novel Cardiac Patch Generated Through Tissue Engineering
Presenting Author: Nohra Elsy Beltrán Vargas

11:00 AM – 11:05 AM | 47 – Research On The Bovine Acellular Dermal Matrix Bridging Reconstruction For Massive Rotator Cuff Tears In Rabbits
Presenting Author: Luyi Sun

11:05 AM – 11:10 AM | 48 – Surface Modification Of Polyester-based Microscaffolds: Towards The Biofunctionalization In The Third Strategy Of Tissue Engineering
Presenting Author: Oliver Kopinski-Grünwald

11:10 AM – 11:15 AM | 49 – Impact Of Human Recombinant Irisin On Tissue-engineered Skeletal Muscle Structure And Function
Presenting Author: Eileen Su

11:15 AM – 11:20 AM | 50 – Hierarchical Bioinspired Tissue Engineering Vascular Graft For Surgical Bypassgrafting
Presenting Author: Michele Carrabba

11:20 AM – 11:25 AM | 51 – Nitric Oxide And Oxygen Releasing Gelma Microneedle Array Patch For Diabetic Wound Healing
Presenting Author: Anwarul Hasan

11:30 AM – 1:00 PM | Lunch on Own

Enjoy lunch at one of the many restaurants located in and around the convention center.

1:00 PM – 2:00 PM | FTERM Panel: Global Challenges on TERM Research and Its Translation

Chairs: Rui Reis
Location: Ballroom 6E
Description: The International Fellows of Tissue Engineering and Regenerative Medicine (FTERM) was created to recognize a distinguished leader within the tissue engineering and regenerative medicine field. FTERM was established to recognize an individuals role in shaping the tissue engineering and regenerative medicine field and TERMIS. FTERM is a Honorary status to recognize individuals that have made outstanding contributions to the field of TERM, with outputs of clear professional excellence. The distinguished members of TERMIS that are recognized as Fellows should be role models for members of the Society and others in the field. Fellows are expected to foster new activities and continue to act as leaders in the field, supporting its development. FTERM sessions are organized at World Congresses or at any of the 3 different Chapter meetings. They are Chaired by the Present (Previous TERMIS Global President, provided she/he is a FTERM) or a Past Chair of the College of International Fellows of Tissue Engineering and Regenerative Medicine. The session can be on a a specific topic and is based on a Panel discussion with different FTERM. The audience can ask questions and debate with the Panel. The session in the TERMIS World Congress in Seattle will be adressing: “Global Challenges on TERM Research and Its Translation”

Panelists:
Anthony Atala
Alicia El Haj
Martha Fontanilla
Buddy Ratner
Antonella Motta

2:00 PM – 3:30 PM | Scientific Concurrent Session 2
Biofabrication Strategies for Advanced 3D In Vitro Models

Chairs: Wojciech Swieszkowski & Jinah Jang
SYIS Co-Chairs: Eleonora Zanrè
Location: Ballroom 6E
Session Topic: Biofabrication
Description: Biofabrication technologies have geared to a level of complexity that today enables the generation of functional human 3D in vitro models that could be used for different purposes, spanning from more fundamental studies to understand pathological mechanisms, to the screening of new therapies and drugs. Examples of such models are already in place for several tissues and organs such as kidney, liver, heart, neuromuscular junctions, bone, and glands.
In this special session, we would like to bring together different keynote speakers advancing this field of application of biofabrication technologies, across the 3 continents.
The proposal is endorsed by the ISBF as part of the strategic alliance between TERMIS and ISBF

Keynote Speaker:
2:00 PM – 2:30 PM | A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner
Lorenzo Moroni, PhD

Oral Abstract Presentations:
2:30 PM – 2:45 PM | 52 – Direct 3d-bioprinting Of Hipsc-derived Cardiomyocytes To Generate Functional Cardiac Tissues
Presenting Author: Felix Engel

2:45 PM – 3:00 PM | 53 – Biosensor-integrated Multiorgan-on-a-chip Platform For Real-time Monitoring Of Organoid Function
Presenting Author: Seunggyu Jeon

3:00 PM – 3:15 PM | 54 – Developing A Scalable, Modular, Automated And Closed Process For Manufacturing Patient-specific Bone Grafts
Presenting Author:Ali Plankey

3:15 PM – 3:30 PM | 55 – Assemblable Bioprinted Hepatic Tissue Modules To Build Volumetric Liver Grafts With Hierarchical Vascular Networks
Presenting Author: Daekeun Kim

Bioengineered Models of Metastasis

Chairs: Aleksander Skardal & Shay Soker
SYIS Co-Chairs: Damian Hutchins
Location: Room 611/612
Session Topic: Cancer
Description: Advances in 3D cell culture technologies, biomaterials, and biofabrication methodologies have led to development of 3D tumor model platforms, such as tumor organoids, engineered 3D tumor constructs, and microfluidic device-based tumor-on-a-chip systems. The inclusion of different cell types, present in the tumor, as well as 3D organization, allow many of these models to be physiologically representative of in vivo tumor and tumor microenvironment (TME) biology, an essential requirement for anti-cancer treatment evaluation ex vivo. These 3D systems can mimic pathological and physical characteristics of tumors, which supports preservation of mutational profiles in cancer cells. Furthermore, they have advantages over animal models, being made from primary human tumor cells and easily controlled and manipulated in the laboratory to attain desired tumor tissue characteristics. Notably, human cancer patients largely do not die from primary tumors, but rather from metastases. In this session, we will highlight cutting edge bioengineered 3D in vitro models of tumor progression and metastasis, including integration of treatment testing and drug development, and personalized chemotherapy and immunotherapy precision oncology. Bioengineered metastasis model technologies continue to develop rapidly for applications in academic, clinical, and pharmaceutical settings.

Keynote Speaker:
2:00 PM – 2:30 PM | From Single Cell to Metastasis on a Chip: Unraveling Tumor Heterogeneity in Adrenocortical Carcinoma
Priya Dedhia MD, PhD

Oral Abstract Presentations:
2:30 PM – 2:45 PM | 56 – Tissue Engineering A Humanized Rat Model For Osteosarcoma Research
Presenting Author: Jonathan Gospos

2:45 PM – 3:00 PM | 57 – RCAN1.4 Regulates Tumor Cell Engraftment And Invasion In A Thyroid Cancer To Lung Metastasis-on-a-chip Microphysiological System
Presenting Author: Sydney Anderson

3:00 PM – 3:15 PM | 58 – Engineered Human Bone Marrow Captures Breast Cancer-induced Changes In Hematopoiesis
Presenting Author: Pamela Graney

3:15 PM – 3:30 PM | 59 – Nuclear Deformation And Rupture During Intravascular Migration Through A Mineralized Matrix Are Key Mediators Of Prostate Cancer Metastasis To Bone
Presenting Author: Avathamsa Athirasala

Vascularization in Tissue Engineering

Chairs: Jelena Rnjak-Kovacina
SYIS Co-Chairs: Sargol Okhovatian
Location: Room 606/607
Session Topic: Cardiovascular/Angiogenesis/Blood
Description: A major challenge in engineered tissues with three-dimensional (3D) architecture has been the generation of functional microvasculature to deliver oxygen and nutrients and to remove waste. Strategies include patterning of vessel structures, seeding of cells that promote neovascularization, promotion of angiogenesis from the host, cell self-assembly, and in vivo tissue engineering. Additionally, vascularization is needed to advance 3D in vitro tissue models, which have emerged as valuable tools for longitudinal studies on tissue development, function, and disease progression. This session will focus on new and emerging research to vascularize a variety of engineered tissues both in vitro and in vivo. Studies testing functional interactions between engineered vessels and engineered tissues are especially encouraged. It will also explore cutting-edge research and breakthroughs in the field of vascularization within 3D in vitro models, including strategies for recapitulating vascular complexity, the role of vascularization in tissue development and functionality, and the use of vascularized models in studying diseases and testing therapeutic interventions.

Keynote Speaker:
2:00 PM – 2:30 PM | Biofabrication of advanced heart and kidney on-a-chip models
Milica Radisic, PHD, PENG, FRSC, FCAE, FAIMBE, FTERM, FBMES

Oral Abstract Presentations:
2:30 PM – 2:45 PM | 60 – Enhancing Cell-based Therapies With Peptide-modified Thermo-responsive Citrate-based Biomaterials For Treatment Of Critical Limb Ischemia
Presenting Author: Bin Jiang

2:45 PM – 3:00 PM | 61 – FRESH 3D Bioprinting Of Volumetric Vascularized Scaffolds To Create Functional Pancreatic-like Tissue
Presenting Author: Daniel Shiwarski

3:00 PM – 3:15 PM | 62 – Alginate Microfibers As Anisotropic Porogens To Enhance Vasculogenic Assembly In Dense Hydrogels
Presenting Author: Firaol Midekssa

3:15 PM – 3:30 PM | 63 – Bioprinting And Microvascular Assembly Within PEGNB Granular Materials
Presenting Author: Irene Zhang

Immunomodulation to Improve Tissue Regeneration

Chairs: Yang Zhang & Julien Legrand
SYIS Co-Chair: Stéphane Petrousek
Location: Room 618/619/620
Session Topic: Immunoengineering
Description: The immune system plays an indispensable role in the process of tissue regeneration following damage as well as during homeostasis. Successful regeneration requires a balanced immune cell response, with the recruitment of accurately polarized immune cells at desired time points in an appropriate quantity. This session comprises research that not only investigates the interaction between the immune system and tissue regeneration and potential molecules required for successful regeneration, but also aims to inhibit, promote, alter, or monitor this interaction to enhance tissue remodeling and regeneration.

Keynote Speaker:
2:00 PM – 2:30 PM | Self-Tolerance and Immunoregulation after Traumatic Soft Tissue Injury
Kaitlyn Sadtler, PhD

Oral Abstract Presentations:
2:30 PM – 2:45 PM | 64 – Local Activation Of Regulatory T Cells Enhances Regeneration In Calvarial Bone Defects
Presenting Author: Gabriele Nasello

2:45 PM – 3:00 PM | 65 – Modulating Immune-stem Cell Crosstalk To Enhance Bone Regeneration Via Tuning Compositions Of Macroporous Scaffolds
Presenting Author: Ni Su

3:00 PM – 3:15 PM | 66 – Role Of Macrophage In Sensory Innervation And Cutaneous Wound Healing
Presenting Author: Jiangang Xu

3:15 PM – 3:30 PM | 67 – Exploring The Dynamic Interplay Of Neuroinflammatory Signals In The Intestine: Insights Into Pro- And Anti-inflammatory Cytokines And Neuropeptides
Presenting Author: Enrique Escarda-Castro

Bone Tissue Engineering

Chairs: Behnam Akhavan & Saber Aminyavari
SYIS Co-Chair: Eman Mirdamadi
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description: Bone tissue engineering can provide transformative solutions to a wide range of musculoskeletal disorders, from fractures and bone defects to degenerative diseases like osteoporosis and osteoarthritis, ultimately improving patients’ quality of life. In this symposium, we cover recent advances in various aspects of bone tissue engineering, from the development of advanced biomaterials, such as biodegradable scaffolds and hydrogels, to biomimetic functional interfaces and micro/nano-structured coatings. The symposium also highlights personalized implant solutions, such as those created through additive manufacturing techniques, including 3D bioprinting. Other topics of interest include, but are not limited to, bioinspired constructs, vascularization strategies, mechanical stimulation, in vitro models for evaluating engineered bone tissue constructs, and clinical translation considerations, including the development of regulatory pathways for bone tissue engineering products.

Keynote Speaker:
2:00 PM – 2:30 PM | Innovations in Nanostructured 3D-Printed Bioceramics for Personalized Bone Healing
Hala Zreiqat, PhD

Oral Abstract Presentations:
2:30 PM – 2:45 PM | 68 – In Vitro Vascularization Predicts Allograft Healing Of Hydrogel-based Tissue Engineered Periosteum
Presenting Author: Alyson March

2:45 PM – 3:00 PM | 69 – 3d-printed Polycaprolactone-allograft Constructs With Controlled Osteoinductive Releasing Nanogels For Bone Regeneration
Presenting Author: Eman Mirdamadi

3:00 PM – 3:15 PM | 70 – Biomimetic Electrical/photothermal Coordinated Nanocomposite Membrane For Modulating Inflammatory Microenvironment And Improving Bone Regeneration
Presenting Author: Yusi Guo

3:15 PM – 3:30 PM | 72 – Spatio-temporal Neuroangiogenic Scaffold For Tissue Regeneration In Medication-related Osteonecrosis Of The Jaw Using Bioactive Elastin-like Recombinamers (ELRs)
Presenting Author: Israel Gonzalez de Torre

Biopreservation Technologies for Extended Storage of Organs and Tissues

Chairs: Basak Uygun & Birgit Glasmacher
SYIS Co-Chair: Juan Carlos Palomeque
Location: Room 615/616/617
Session Topic: Respiratory, Urologic & Gastrointestinal
Description: Biopreservation is an essential process for storage, transport and distribution of tissue engineered products that will facilitate widespread application of the end product. The process involves keeping biospecimens at low temperatures to reduce or suspend their physiochemical and metabolic activities and then recovering them to physiological states at a desired future time. Biopreservation has been critical in a number of areas of regenerative medicine such as reproductive cells and tissues for assisted reproductive technology, tissues and organs for transplantation, or stem cells, blood cells or genetically engineered cells for cell based medicine. The goal of this session is to bring together investigators who focus their work in studying biopreservation for extended storage of tissue engineered products (e.g., organoids, microphysiological systems, tissues and whole organ constructs) including but not limited to respiratory, urologic and gastrointestinal systems. Topics of interest include cooling and rewarming technologies, strategies for protection of biospecimens from cold injury, biology at cold temperatures and other related subjects.

Keynote Speaker:
2:00 PM – 2:30 PM | Long-term Supercooled Preservation of Red Blood Cells – Shifting Paradigms
Berk Usta, Associate Professor of Surgery

Oral Abstract Presentations:
2:30 PM – 2:45 PM | 72 – Life On Hold – Cryopreservation Of Kidneys And Pancreatic Islets By Vitrification For Transplantation
Presenting Author: Joseph Sushil Rao

2:45 PM – 3:00 PM | 73 – Incremental Switch Improves 24-hour Supercooling Preservation Outcomes Of Vascularized Composite Allografts In Rodents
Presenting Author: Irina Filz von Reiterdank

3:00 PM – 3:15 PM | 74 – Vascular Microphysiological Systems As An Organ Preservation Testbed
Presenting Author: Yongdeok Kim

3:15 PM – 3:30 PM | 75 – Electrospun Magnetic Membranes For Cryopreservation
Presenting Author: Birgit Glasmacher

Harnessing Peptide and Protein-based Materials for Tissue Engineering

Chairs: Sarah Heilshorn & Alberto Saiani
SYIS Co-Chair: Nikolaos Pipis
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: Bio-molecular self-assembly represents a simple and efficient route to the construction of large, complex structures across multiple length scales. This sparked evolution of numerous creative approaches for designing functional biomaterials in the tissue engineering realm, particularly from the peptide and protein-based building molecules. Specifically, this symposium will focus on the significant progress that has been made towards understanding the design rules, mechanisms and driving forces behind the design and hierarchical assembly of peptides and proteins and derivatives thereof, bringing a set of new biomaterials revolutionizing tissue engineering. Through precise molecular modifications using natural and non-natural amino acids, biomaterials spanning controlled release systems, new matrices for organoids growth and 3D cell culture, as well as components of miniaturized chips are developed.

Keynote Speaker:
2:00 PM – 2:30 PM | Mussel Adhesive Protein Inspired Polymers for Tissue Repair
Professor Phillip B Messersmith

Oral Abstract Presentations:
2:30 PM – 2:45 PM | 76 – Engineering Synthetic Protein Condensates For Tissue Engineering
Presenting Author: Sergio Acosta

2:45 PM – 3:00 PM | 77 – Antimicrobial Properties Of Highly-charged Self-assembling Polypeptides
Presenting Author: María Puertas-Bartolomé

3:00 PM – 3:15 PM | 78 – Peptide-based Bioink With Switchable Mechanical Properties
Presenting Author: Hadi Rastin

3:15 PM – 3:30 PM | 79 – Controlled Delivery Of UPI Peptide Via PLGA Microparticles To Enhance Endothelization
Presenting Author: Chris Bashur

Single-cell Analysis of Engineered Tissues

Chairs: Micha Sam Brickman Raredon & Riccardo Gottardi
SYIS Co-Chair: Gustavo Henrique Almeida
Location: Room 608-609
Session Topic: Stem Cell Therapies, Developmental Biology and Cell Signaling
Description: Single-cell technologies have revolutionized our understanding of tissues. However, it remains difficult to compare organoids, engineered tissues, and ex vivo cultured tissues to native references. This is largely because the majority of computational tools and workflows are not designed specifically for this task. We need to research how to best compare engineered and native tissues using single-cell approaches, and how these approaches may help us to gain disease- and development-relevant biological insight. This session intends to bring together experts from across discipline, in multiple organ systems, to provide a general forum for discussion and sharing of expertise. The session will focus on research leveraging existing single-cell techniques to understand engineered tissue biology, and on pioneering work to develop next-generation computational and biological approaches that can help tissue engineering to develop as a field.

Keynote Speaker:
2:00 PM – 2:30 PM | Unveiling the Mysteries of Vascular Development and Regeneration with Advanced Human Organoid Models
Mingxia Gu, MD, PhD

Oral Abstract Presentations:
2:30 PM – 2:45 PM | 80 – Systems-level Reverse Engineering Of Lung
Presenting Author: Allison Greaney

2:45 PM – 3:00 PM | 81 – Single Cell Analysis Reveals Diverse Senescent Cell Phenotypes in the Foreign Body Response to Synthetic Implants
Presenting Author: Alexandra Rindone

3:00 PM – 3:15 PM | 82 – Morphology-based Deep Learning For Prediction Of Osteogenic And Adipogenic Differentiation
Presenting Author: Shue Wang

3:15 PM – 3:30 PM | 83 – Functional Guide-rna Cell Barcoding For Tracking Hipsc Clonal Lineages During Directed Differentiation Into Cardiomyocytes
Presenting Author: Sogu Sohn

Business Plan Competition

Chairs: Nilabh Kajave, Simon Cool & Johannes Grillari
Location: Room 602/603/604
Session Topic: Special Session
Description: The top submissions will be presented at the Finals.  An expert judging panel will select the winner.  Apart from living a unique experience, finalists will receive mentorship, feedback and exposure. 

Presenters:
Moo-Yeal Lee – Bioprinting Labs Inc
Chad Ronholdt – ASC Biosciences
Hugo Level – Capcyte Biotherapeutics
Derek Dashti – D&P BIo Innovations
Magdalene Ho – Sekhmet
Narintadeach Charoensombut – MatrX

RAPID FIRE: Tissue Engineering Scaffolds in Regenerative Medicine

Chairs: Rachael Moses & Farzaneh Moghtader
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials

Rapid Fire Presentations:
2:00 PM – 2:05 PM | 84 – Determining Optimal Scaffold Geometries For Rotator Cuff Repair: A Parametric Finite Element Approach
Presenting Author: Samuel Winston


2:05 PM – 2:10 PM | 85 – Best Microarchitectures Of 3d-printed Bone Substitutes For Bone Healing And Augmentation.
Presenting Author: Franz Weber


2:10 PM – 2:15 PM | 86 – Vascularized Stem Cell-based Constructs For Bone Tissue Engineering
Presenting Author: Jana Musilkova


2:15 PM – 2:20 PM | 87 – Preclinical Evaluation Of Polymer-based Composites For Patient-individual Additive Manufacturing Of Biodegradable Jawbone Implants – A Minipig Study
Presenting Author: Corina Vater


2:20 PM – 2:25 PM | 88 – The Importance Of Amino Groups In Biomaterial Coatings For Cell Response
Presenting Author: Susanne Staehlke


2:30 PM – 2:35 PM | 89 – Development Of A Scaffold-based Platform For Simultaneousdelivery Of Microrna Mimics And Microrna Inhibitor For The Treatment Of Large-volume Bone Defects
Presenting Author: Joanna Sadowska


2:35 PM – 2:40 PM | 90 – Photocrosslinked Silk Fibroin Microgels And Microgel Scaffolds For Biomedical Applications
Presenting Author: Jelena Rnjak-Kovacina

2:40 PM – 2:45 PM | 91 – Impact Of Microgel Size And Interstitial Voids On Cartilage Tissue Formation By Encapsulated Mesenchymal Stromal Cells
Presenting Author: Jess Frith


2:45 PM – 2:50 PM | 92 – Tropoelastin Preserves Mesenchymal Stromal Cell Phenotype And Delays Senescence
Presenting Author: Sunny Lee


2:50 PM – 2:55 PM | 93 – Annealed Pvdf-trfe Scaffolds Enhance Piezoelectric Response And Membrane Stiffness For Nerve Repair Applications
Presenting Author: Maksym Krutko


3:00 PM – 3:05 PM | 94 – Giving It A Twist: Boosting Ultrastructural Biomimicry Of Collagen
Presenting Author: Vivien Priebe


3:05 PM – 3:10 PM | 95 – Developing A 3D Chronic Wound Model Using Animal-free Products.
Presenting Author: Rachael Moses


3:10 PM – 3:15 PM | 96 – Matrix Mechanics Overcomes The Effect Of Pore Size On Angiogenic:Osteogenic Coupling Over Time In Porous Hydroxyapatite Scaffolds
Presenting Author: Eugenia Morales Carrillo


3:15 PM – 3:20 PM | 97 – Investigation Of Pericyte Settlement On Microscale Morphology In Vascular Regeneration
Presenting Author: Hedele Zeng


3:20 PM – 3:25 PM | 98 – Hydrogel Microcarriers Reduce Development Of Msc Senescence In Small And Large Scale Culture
Presenting Author: Zoe Mote

3:30 PM – 4:00 PM | Transitional Break

4:00 PM – 6:00 PM | Opening Plenary Session: Bioelectronic Tissue Interfaces for Inflammation Monitoring and Modulation

Location: Ballroom 6 B/C
Plenary Speaker:
Dr. Shana Kelley
President of the Chan Zuckerberg Biohub Chicago
Neena B. Schwartz Professor at Northwestern in the Departments of Chemistry, Biomedical Engineering, and Biochemistry & Molecular Genetics
Chicago, IL USA

6:00 PM – 7:30 PM | Opening Reception & Poster Session I

Location: Hall 4A

Meet with exhibitors to learn about their services and products. Check out the great science in the poster presentations. Take time to meet with the authors and discuss their findings. Light appetizers and drinks will be served.

8:00 PM – 10:00 PM | SYIS Social at GameWorks (ticketed event)

Location: Off-site at GameWorks, 1511 7th Ave, Seattle, WA 98101

The SYIS Social is a welcoming reception for students and young investigators at the conference. This year’s Social will be held at Gameworks, a fun arcade nearby the conference venue. Drinks, snacks, and unlimited arcade access will be provided during the event. A ticket must be purchased during the conference registration to attend.

Wednesday, June 26

Day 2: Wednesday, June 26

7:00 AM – 7:30 PM | Registration Desk Open

The registration desk will be located in the Atrium on the Fourth Floor of the Seattle Convention Center Arch Building.

7:00 AM – 6:00 PM | Speaker Ready Room Open

Location: Room 613

Speakers should check-in at the speaker ready room at least 2 hours prior to their session start time. Staff will be on hand to answer questions about av setup in presentation rooms and assist with any presentation edits.

8:00 AM – 9:30 AM | Scientific Concurrent Session 3
Biofabrication Strategies for Advanced 3D In Vitro Models – Session II

Chairs: Yu Shrike Zhang & Oksana Dudaryeva
SYIS Co-Chair:Carlos Guimaraes
Location: Ballroom 6E
Session Topic: Biofabrication
Description: Biofabrication technologies have geared to a level of complexity that today enables the generation of functional human 3D in vitro models that could be used for different purposes, spanning from more fundamental studies to understand pathological mechanisms, to the screening of new therapies and drugs. Examples of such models are already in place for several tissues and organs such as kidney, liver, heart, neuromuscular junctions, bone, and glands. In this special session, we would like to bring together different keynote speakers advancing this field of application of biofabrication technologies, across the 3 continents. The proposal is endorsed by the ISBF as part of the strategic alliance between TERMIS and ISBF

Oral Abstract Presentations:
8:00 AM – 8:15 AM | 99 – Biofabrication Of A 3d In Vitro Model Recapitulating The Structure Of An Ovine Intervertebral Disc
Presenting Author: Emmaëlle Carrot

8:15 AM – 8:30 AM | 100 – Multiscale Patterning Of 3D Microvascular Scaffolds Via Image Stack-guided Photodegradation
Presenting Author: Shiyu Yang

8:30 AM – 8:45 AM | 101 – Human Vascularized Islet Organ (hVIO) As An Extracorporeal Model For The Study Of Physiopathology And Drug Screening In Diabetes
Presenting Author: Alessia Neroni

8:45 AM – 9:00 AM | 102 – Volumetric Bioprinting Of Multi-scale Vasculature Via Photopolymerization-induced Phase Separation For Vascularized Engineered Tissues
Presenting Author: Oksana Dudaryeva


9:00 AM – 9:15 AM | 103 – A 3D Bioprinted Kidney Proximal Tubule Model For The Investigation Of Ammoniagenesis
Presenting Author: Brian Coffin


9:15 AM – 9:30 AM | 104 – 3d Bioprinted Liver-on-a-chip For Drug Cytotoxicity Screening
Presenting Author: Sang Jin Lee

New Biofabrication and Organoid-based Strategies for Regenerative Healthcare – ISBF meets TERMIS

Chairs: Khoon Lim & Gabriella Lindberg
SYIS Co-Chair: Timothy Mitchell
Location: Room 606/607
Session Topic: Organoids, Bioreactors & Organ-on-Chip
Description: The field of Biofabrication has become an integrated discipline in Tissue Engineering and Regenerative Medicine (TERM) as key-enabling technology to generate highly advanced 3D engineered constructs to better recapitulate the complexity of native tissues. As such, the convergence of Biofabrication, via bioprinting and bioassembly, and TERM is currently expediting clinical translation of engineered tissues by addressing some of the key challenges in the field (i.e., vascularization, scalability, multicellularity). Focusing on these advances, this symposium aims to highlight works on i) new bioprinting and bioassembly technologies, ii) the emergence of multi-technology biofabrication platforms, where multiple techniques (such as extrusion, light-based, magnetic and acoustic), interact together to recreate the native hierarchical composition of native tissues, and iiI) the role of biofabrication techniques in providing geometrical and biochemical cues to guide the self-assembly of cellular aggregates and organoids, and their applications in regenerative medicine. The symposium is also endorsed by the International Society for Biofabrication (ISBF).

Keynote Speaker:
8:00 AM – 8:30 AM | Designer biomaterials as bioprinting inks
Sarah Heilshorn, PhD

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 105 – Light-mediated Control Of Biological Reactions And Optogenetics In Volumetric Bioprinting
Presenting Author: Davide Ribezzi

8:45 AM – 9:00 AM | 106 – Fresh 3d Bioprinting Of Insulin-secreting Endothelialized High-density Min6 Spheroid Constructs
Presenting Author: Ezgi Bakirci


9:00 AM – 9:15 AM | 107 – A Culture Platform With Alveolar Geometry For Induced Pluripotent Stem Cell-derived Distal Lung Organoids
Presenting Author: Dana Brinson


9:15 AM – 9:30 AM | 108 – Biofabrication And Stimulation Of Magnetically Augmented Callus Assembloids Accelerates Bone Formation In Vivo
Presenting Author: Konstantinos Ioannidis

Biophysical Stimuli and Stimuli-Responsive Materials for Drug Delivery and Tissue Regeneration

Chairs: Leonardo Ricotti & Lino Ferreira
SYIS Co-Chair: Manuella Godoi
Location: Room 615/616/617
Session Topic: Controlled Delivery of Therapeutics for Tissue Engineering
Description: The session will describe the most recent advances and will discuss the open issues and future perspectives of biophysical stimulation tools and stimuli-responsive materials. Biophysical stimuli can be exploited for delivering energy in different forms (e.g., light, electrical or magnetic fields, ultrasound, etc.) to cells and tissues, directly promoting their healing/regeneration. Stimuli-responsive hydrogels and stimuli-responsive nanomaterials are further emerging tools that can be exploited to engineer cells and tissues. Indeed, their responsiveness to various physical (temperature, light, electric and magnetic fields, ultrasound), chemical (pH, glucose, and ionic strength), or biological (enzymes and antigens/antibodies) stimuli allows them to amend their configuration, biodegradability, biological moieties, and different physicochemical characters, thus delivering temporal and spatial cues to stem cells, enhancing their regenerative capability over time or enabling innovative targeted therapies. Indeed, the interplay between exogenous energy sources and stimuli-responsive materials can be exploited for releasing drugs and other therapeutic molecules in situ and on-demand, acting in a selective way and minimizing side effects. The session will describe cutting-edge results in this field, exploring the variety of exogenous stimuli for promoting tissue regeneration and drug delivery, in synergy with endogenous ones, and the different materials that can be devised for maximizing the effectiveness of this paradigm.

Keynote Speaker:
8:00 AM – 8:30 AM | The synergy of magnetic responsive biomaterial systems and magnetic stimuli in tendon regeneration
Manuela Gomes

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 220 – Knowledge-generation Platform For Unravelling Bone Regeneration Mechanisms Induced By Biophysical Stimuli
Presenting Author: Stefano Gabetti

8:45 AM – 9:00 AM | 110 – Tailored Gelatin Methacryloyl-based Hydrogel With Near-infrared Responsive Delivery Of Qiai Essential Oils Boosting Reactive Oxygen Species Scavenging, Antimicrobial, And Anti-inflammatory Activities For Diabetic Wound Healing
Presenting Author: Na Meng

9:00 AM – 9:15 AM | 111 – Multiple Stimuli-Responsive Injectable Hydrogel For Functional Tissue Regeneration
Presenting Author: Silvia Panseri

9:15 AM – 9:30 AM | 112 – Near Infrared Light-activated Formulation For The Spatial Controlled Release Of Crispr-cas9 Ribonucleoprotein For Brain Gene Editing
Presenting Author: Lino Ferreira

In Vitro Models to Study the Immune System and Organ Interactions

Chairs: Pamela Graney & Carla Huerta-Lopez
SYIS Co-Chair: Maria Karkanitsa
Location: Room 618/619/620
Session Topic: Immunoengineering
Description: This session aims to describe advancements in recent years to include immune-competent models and components in engineering human tissue models. Over the last decade, organs-on-a-chip and engineered tissues have emerged as new tools to study human biology; however, many of these models have not included the complex immune system in their development. This session will highlight recent advances in engineering model systems with integrated immune components, whether as tissue-resident immune populations or infiltrating communicators from circulatory or immune organ models. These immune-competent models may better advance the complexity of tissue engineered systems, as well as help model complex diseases in the body.

Keynote Speaker:
8:00 AM – 8:30 AM | Resident and infiltrating human macrophage functions in engineered heart tissues and electric fields
Michael Monaghan, PhD

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 113 – Bioreactor Design To Achieve Immune Cell Perfusion In Liver Models For The Study Of The Extracellular Matrix-immune Cell Interactions In Liver Fibrosis
Presenting Author: Sara Campinoti

8:45 AM – 9:00 AM | 114 – Engineer 3D In Vitro Models To Mimic Aging Effects On Inflammation And Delayed Bone Healing
Presenting Author: Ni Su

9:00 AM – 9:15 AM | 115 – Extracellular Matrix Mechanics Modulates Macrophage Fate
Presenting Author: Ya Guan

9:15 AM – 9:30 AM | 116 – Tissue Engineered Fibroblastic Reticular Network Regulates Antibody Production By PBMCs
Presenting Author: Mei ElGindi

Biomaterials for Immunomodulation and Tissue Regeneration – Session II

Chairs: Maria Coronel & Marian Hettiaratchi
SYIS Co-Chair: Leonor Teles
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description:

Oral Abstract Presentations:
8:00 AM – 8:15 AM | 117 – Magnesium Ions-releasing Bioactive Hydrogels For In Situ Tissue Regeneration Via Macrophage Polarization
Presenting Author: Jeong Min Kim

8:15 AM – 8:30 AM | 118 – Advancing Periodontal Tissue Regeneration: Harnessing The Immunomodulatory Potential Of Cerium-doped Zif-62 Nanomaterials
Presenting Author: Tian Xu

8:30 AM – 8:45 AM | 119 – In Vitro Modulation Of Macrophage Phenotype By 3D Custom-made Micro Scaffolds
Presenting Author: Chiara Martinelli

8:45 AM – 9:00 AM | 120 – Liver-targeting Microparticles For Hepatocyte Transplantation
Presenting Author: I-Ning Lee

9:00 AM – 9:15 AM | 121 – Biomaterials-based Platform For Ex Vivo T Cell Expansion
Presenting Author: Jeremy Teo

9:15 AM – 9:30 AM | 122 – Evaluation Of Bi-layer Silk Fibroin Grafts For Inlay Vaginoplasty In A Rat Model
Presenting Author: Gokhan Gundogdu

Bone Tissue Engineering – Session II

Chairs: Nathalie Bock & Tomas Gonzalez-Fernandez
SYIS Co-Chair: Aliaa Karam
Location: Ballroom 6C
Session Topic: Musculoskeletal

Oral Abstract Presentations:
8:00 AM – 8:15 AM | 123 – Developing Pseudovirus-like Nanoparticle To Package RNA For Bone Regeneration
Presenting Author: Pin-Yan Chen

8:15 AM – 8:30 AM | 124 – An Advanced Parathyroid Hormone-1-34 Gene-Activated Scaffold For Osteoporotic Bone Repair
Presenting Author: Austyn Matheson

8:30 AM – 8:45 AM | 125 – Surface Topography-induced Macrophage Polarization To Promote Bone Regeneration In Type-1 Diabetes Mellitus
Presenting Author: Min Guk Kim

8:45 AM – 9:00 AM | 126 – Endochondral Ossification Driven Repair Of Refractory Bone Defects Using Bmsc Regenerated Cartilage On Decalcified Bone Scaffolds
Presenting Author: Peiling Zhang


9:00 AM – 9:15 AM | 127 – Engineering Stem Cells To Produce Exosomes With Enhanced Bone Regeneration Effects
Presenting Author: Wei Qiao


9:15 AM – 9:30 AM | 128 – Physical Stimulation Of Stem Cells Using Surface Acoustic Waves
Presenting Author: Kimia Witte

Tissue Engineering Approaches in Ocular Regenerative Medicine

Chairs: Budd Tucker & Kapil Bharti
SYIS Co-Chair: Sophia Lu
Location: Room 611/612
Session Topic: Ophthamologic
Description: This session will bring together experts working in the field of ocular regenerative medicine. Speakers will present cutting edge research in tissue, cell, and genome engineering designed to prevent vision loss and restore sight to the blind.

Oral Abstract Presentations:
8:00 AM – 8:15 AM | 129 – Multi-material 3D Bioprinting Of Human Stem Cell Based Corneal Structures With Stroma And Epithelium
Presenting Author: Suvi Huhtanen

8:15 AM – 8:30 AM | 130 – A Single-injection, Cell-instructive Hydrogel Against Age-related Macular Degeneration
Presenting Author: Anna Abbadessa

8:30 AM – 8:45 AM | 131 – Development Of A Multi-layered Dynamic In Vitro Trabecular Meshwork Model For Comprehensive Glaucoma Drug Screening
Presenting Author: Magdalena Gladysz

8:45 AM – 9:00 AM | 132 – Tissue-engineered Human Corneal Endothelium
Presenting Author: Karl Brown


9:00 AM – 9:15 AM | 133 – Transplantation Of CGMP Compliant IPCS-derived Retinal Progenitor Cells
Presenting Author: Laura Bohrer


9:15 AM – 9:30 AM | 134 – A Pre-Vascularized Structured Hydrogel Membrane To Rescue The Outer Blood-Retina Barrier In Retinal Dystrophies
Presenting Author: Chloé Dujardin

Cell-based Materials for Regeneration and Disease Treatment

Chairs: Mariana Oliveira
SYIS Co-Chair: Caterina Piunti
Location: Room 608/609
Session Topic: Stem Cell Therapies, Developmental Biology and Cell Signaling
Description: (Bio)materials based on cells and/or their derivatives (e.g., extracellular matrices – ECMs, and vesicles) have shown promising properties as tailorable structures for the delivery of bioactive agents, as well as supporting structures for tissue engineering and regenerative medicine. This Symposium addresses the exploration of cells as building blocks of scaffold-free or low-biomaterial living or devitalized materials with therapeutic potential. Also, reports on the use of extracellular elements produced by cells – including extracellular vesicles (EVs) of different dimensions and sources, and in vitro-obtained ECMs – are welcome to submit abstracts in this Symposium. Applications of the reported materials may include, but are not restricted to tissue engineering for disease modelling, cell-derived nano- to macrometric constructs for molecule delivery, tissue regeneration, and immunotherapies.

Keynote Speaker:
8:00 AM – 8:30 AM | Engineering scaffold-free tissue constructs via modular assembly, cell-only bioprinting and 4D strategies
Eben Alsberg Ph.D.

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 135 – Cell Membrane Camouflaged Nanoparticle For Targeted Osteoporosis Therapy
Presenting Author: Anoop Puthiyoth Dayanandan

8:45 AM – 9:00 AM | 136 – Therapeutic Application Of Stem Cell Spheroid-derived 3D Decellularized Matrix For Traumatic Brain Injury
Presenting Author: Chieh-Cheng Huang

9:00 AM – 9:15 AM | 137 – Expansion Of Hematopoietic Stem Cells On Engineered Human Liver Cultures For Regenerative Medicine
Presenting Author: Ashlin Michell

9:15 AM – 9:30 AM | 138 – Crispr Activation Of Il-10 In Asc By Hybrid Baculovirus For Neuropathic Pain Attenuation
Presenting Author: Shu-Wei Yang

Pediatric Tissue Engineering – Clinical Translation and Recent Advances

Chairs: Riccardo Gottardi & Renea Sturm
SYIS Co-Chair: Ram Rao
Location: Room 602/603/604
Session Topic: Special Session
Description: The field of tissue engineering emerged from the clinical necessity for pediatric tissue and organ repair or replacement. Developing tissue engineering and regenerative medicine approaches for pre-term/neonates, infants, children, and adolescents requires a specific focus on the unique physiology of these patient populations. Growth is an important consideration for successful design and implementation of these technologies. Additionally, the heterogeneity of the presenting pathologies poses challenges for customized or patient-specific solutions. Implementing these solutions clinically to addressing these challenges has propelled the field towards new paradigms for design, manufacture, and repair. This session will showcase pediatric tissue engineering technologies embodying these design attributes accommodating growth and heterogeneity through invited talks in the field of pediatric tissue engineering with a special focus on technologies in the clinic or advanced pre-clinical stages of development. Format will be 3 speakers 25min talks with 5 minutes for QA

Keynote Speaker:
8:00 AM – 8:30 AM | Engineering stem cells and extracellular components to treat birth defects
Aijun Wang, PhD

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 139 – 3D PRINTED PULMONARY HEART VALVES FOR PEDIATRIC PATIENTS
Presenting Author: Houman Savoji

8:45 AM – 9:00 AM | 140 – Collagen Matrix Density Induces Osteosarcoma Chemoresistance In A 3d Tissue Engineered Biomineralized Bone Matrix
Presenting Author: Rameshwar Rao

9:00 AM – 9:15 AM | 141 – Human Lung Bioinks Embedded With Induced Basal Stem Cells Can Be Used To 3d Bioprint Pediatric-sized Airways
Presenting Author: Heather Wanczyk

9:15 AM – 9:30 AM | 142 – Influence Of Parathyroid Hormone 1-34 On Integrity Of Patient-specific Osteogenesis Imperfecta Bone Organoids
Presenting Author: Gian Nutal Schädli

RAPID FIRE: Decellularized ECM materials for TERM

Chairs: Matt Wolf & Feini Qu
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials

Rapid Fire Presentations:
8:00 AM – 8:05 AM | 143 – Rat Liver Extracellular Matrix And Perfusion Bioreactor 4d Culture Promote Human Amnion Epithelial Cell Differentiation Towards Hepatocyte-like Cells
Presenting Author: Sara Campinoti

8:05 AM – 8:10 AM | 144 – The Anti-inflammatory Effect Of Decellularized Extracellular Matrix Hydrogel Microparticles On Lps-induced Acute Lung Injury In Rats
Presenting Author: Chen-Yu Kao

8:15 AM – 8:20 AM | 146 – Effects Of The Soluble Fraction Of Extracellular Matrix On The Esophageal Cancer Cell Phenotype
Presenting Author: Daniela Romero

8:20 AM – 8:25 AM | 147 – Evaluating Effects Of The Protein Components Of An Infusible Decellularized Extracellular Matrix Material For Targeting And Treating Leaky Vasculature Following Myocardial Infarction
Presenting Author: Michael Nguyen

8:30 AM – 8:35 AM | 148 – Increased Extracellular Matrix Complexity Drives Maturation In Primary Hepato-biliary-endothelial Organoid Model
Presenting Author: Lorenzo Caciolli

8:35 AM – 8:40 AM | 149 – The Effect Of Platelet Activating Factor Acetyl-hydrolase On Matrix Bound Nanovesicle Immunomodulatory Activity
Presenting Author: Salma El-Mossier

8:40 AM – 8:45 AM | 150 – Microparticles Based On Solidified Stem Cell Secretome (MIPSOS) For The Treatment Of Diabetic Chronic Wounds
Presenting Author: Anna Blocki

8:45 AM – 8:50 AM | 151 – Fundamental Material Differences Between Hydrogel And Infusible Versions Of Decellularized Ecm Biomaterials
Presenting Author: Alexander Chen

8:50 AM – 8:55 AM | 152 – Cornea-specific Human Adipose Stem Cell -derived Extracellular Matrix For Corneal Stroma Tissue Engineering
Presenting Author: Paula Puistola

9:00 AM – 9:05 AM | 153 – Bioactive Matrix Bound Nanovesicles From Decellularized Bovine Pericardium For Regenerative Medicine Applications
Presenting Author: Dalila Di Francesco

9:05 AM – 9:10 AM | 154 – Convergence Of Extracellular Matrix (ECM)-based Biomaterials And Biomimetic Culture Methods To Bioengineer Humanized In Vivo Bone Models
Presenting Author: Agathe Bessot

9:10 AM – 9:15 AM | 155 – Comparative Analysis Of Extracellular Matrix Architecture And Matrisome In Decellularized Brain Scaffolds And Matrigel®
Presenting Author: Anna Guller

9:15 AM – 9:20 AM | 156 – Urinary Bladder Matrix Hydrogel Improves Anastomotic Healing In A Standardized Rat Model Of Rectal Resection
Presenting Author: Vincent Anto

9:20 AM – 9:25 AM | 157 – Towards An Inhalable Tissue-specific Extracellular Matrix-based Substrate For Targeted Laryngeal Tracheal Regeneration.
Presenting Author: Ramair Colmon

9:00 AM – 7:45 PM | Exhibit Hall Open

Location: Hall 4A

9:30 AM – 10:00 AM | Networking Coffee Break in Exhibit Hall

Location: Hall 4A
Meet with exhibitors to learn about their services and products.

9:30 AM – 10:00 AM | Thematic Working Interest Groups (TWIGs) Organizational Meeting

Location: Room 306

GET INVOLVED! We invite all of our conference registrants to attend the TWIGs Organizational Meeting that will be held after the WFIRM Young Investigator Awards Presentations. We will be discussing the purpose of TWIGs and how to get involved. TWIGs are a great way to participate more directly in TERMIS-AM within thematic areas that align with your research interests. TWIGs help organize and chair conference sessions, as well as host special events. It is also an excellent leadership opportunity within this professional society for members of all stages. For further information on TWIG areas and leadership: https://termis.org/termis-am-thematic-interest-working-group-twigs.

9:40 AM – 9:55 AM | Advancing Nanobiomechanical Research: Large Tissue Area Mapping and Nano Scale Rheology via AFM

Sponsored by: Bruker
Location: Hall 4A
Speaker: Yi Wei

The expansion of atomic force microscopy (AFM) applications to encompass nanomechanical measurements across millimeter to centimeter scales, coupled with the exploration of rheological properties in the frequency domain, introduces a complex array of challenges. The inherent precision and sensitivity of AFM, tailored for atomic and nanoscale interactions, are tested as we extend its scope. In a collaborative study with Prof. Dr. Thorsten Hugel (AFM) and Prof. Dr. Bernd Rolauffs (SCSO), we explore the nanomechanical landscape of osteoarthritis (OA) on a large tissue scale. Through a novel hybrid fluorescence-AFM approach, we successfully correlated superficial chondrocyte spatial organization (SCSO) with microscale elastic modulus and identified nanoscale mechanical property variations in articular cartilage (AC). This technique enabled the precise mapping of elastic modulus variations over extensive areas of native AC, unveiling pivotal insights into the early stages of OA. By elucidating the relationship between cellular organization and mechanical alterations in tissue, our findings offer a new lens through which to view the hierarchical structure of biological tissues such as cartilage.

10:00 AM – 12:00 PM | Plenary Session 1 & EU Chapter Awards

Location: Ballroom 6 B/C

10:00 AM – 10:30 AM | Translational Strategies in Health Technologies
Prof Chwee Teck (C.T.) Lim
NUSS Chair Professor
Director Institute for Health Innovation & Technology
National University of Singapore

10:30 AM – 11:30 AM | Translational Strategies in TERM: Panel Discussion on Regulatory Affairs, Manufacturing, and Scale Up
Moderator: Milica Radisic
Panelists:
Fergal J O’Brien 
Yasuhiko Tabata
Johnna Temenoff
Karen L. Christman

11:30 AM – 12:00 PM | Europe Chapter Awards

12:00 PM – 1:30 PM | Lunch on Your Own

Enjoy lunch at one of the many restaurants located in and around the convention center.

12:00 PM – 1:30 PM | Student-Meet-Mentor Luncheon

Location: Ballroom 6E
Moderators: Sargol Okhovatian, Gabriele Nasello & Mickael Dang

As the signature SYIS event at TERMIS conferences, the Meet-the-Mentor luncheon provides students and young investigators the opportunity to enjoy a multi-course lunch with senior faculty and scientists working in the fields of tissue engineering and regenerative medicine. Mentors will include session chairs, TERMIS faculty members, and local industry leaders. A ticket must be purchased during the conference registration to attend.

12:30 PM – 12:50 PM |  20-minute Sponsored Session

Sponsor:  Phil and Penny Knight Campus for Accelerating Scientific Impact
Speaker:
Location: Room 611/612

1:00 PM – 1:20 PM | Unlock Half a Million in Funding: Tips to Win the Burroughs Wellcome Fund’s Innovations in Regulatory Science Award

Sponsor: Burroughs Wellcome Fund
Speaker: Tammy Collins, Program Officer
Location: Room 611/612

Calling all researchers at TERMIS! Don’t miss this information session on the Burroughs Wellcome Fund’s Innovations in Regulatory Science Awards. Discover what it takes to secure up to $500K in research funding. Join us for a brief yet insightful overview where we’ll reveal exactly what BWF is looking for in award candidates. Elevate your research with insider tips and boost your chances of winning this prestigious grant!

1:30 PM – 3:00 PM | Scientific Concurrent Session 4
Use of Biomaterials and Microfluidic Devices for Tissue Engineered Cancer Models

Chairs: Luiz Bertassoni & Subhas Kundu
SYIS Co-Chair: Maryam Asadikorayem
Location: Room 615/616/617
Session Topic: Cancer
Description: Researchers working in drug development, cancer drug screening platforms, and tissue engineering and regenerative engineering will be able to familiarise themselves with the current methodologies and technologies for developing cancer disease models and early diagnosis. While traditional therapeutic methods may be effective in many cases, they may not be suitable for highly metastatic cancers. When they have already spread and are harder to treat, it exacerbates the challenge of managing this disease. As a result, there is a growing interest in developing complementary tissue-engineered approaches for early cancer diagnosis and treatment to enhance patient recovery. This session will discuss realistic 3D in vitro tumour models for anticancer therapeutic screening. The models will deal with disease microenvironment dynamics, angiogenesis, and cell migration to study and manipulate different cancer treatments. Recent advanced strategies in 3D bioprinting using bio-ink and microfluidic devices allow us to investigate in-depth tumour cell invasion, intravasation, and extravasation) and tissue growth in the 3D microenvironment. A biomimetic biomaterial is expected to provide biochemical and biophysical cues that mimic the in vivo extracellular matrix. This symposium will expose the audience to fabrications of 3D scaffolds and smart hydrogels of synthetic and natural biomaterials, cancer cells and cancer-associated fibroblasts, and 3D cancer cell culture to create disease models. In addition, in vitro tissue-engineered models of the cancer microenvironment and its evolution, preclinical models, engineering of cancer organoids, and cancer lab–on–a–chip for drug development and screening, including the cancer theranostics paradigm. Organizing a session related to treatment constraints will allow us to investigate the cancer microenvironment and innovative treatments deeper using in vitro- and, finally, in vivo models is the demand of the practical uses for cancer therapies through emerging techniques.

Keynote Speaker:
1:30 PM – 2:00 PM | Tackling Complexity in TERM Cell/Material Interactions and Methodologies to Engineer Different Complex In Vitro Disease Cancer Models
Rui Reis, PhD

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 158 – Microfluidic Incubation Of Patient Tumor, Lymph Node, And Peripheral Blood Cells Produces Tumor Reactive Cytotoxic Lymphocytes
Presenting Author: Damian Hutchins

2:15 PM – 2:30 PM | 159 – Using A Blood Brain Barrier (BBB)-on-a Chip To Study How Different Subpopulations Of Glioblastoma Tumor Cells Influence BBB Permeability And Drug Delivery.
Presenting Author: Thomas DePalma

2:30 PM – 2:45 PM | 160 – 3d Bioprinting Ultrasound-responsive Tissue Constructs For Remote-controlled Oncogene Patterning In 3d Tumor Models
Presenting Author: Mary Lowrey

2:45 PM – 3:00 PM | 161 – Microfluidic-Driven Engineering Of Complex 3D Cancer Architectures For Quantitative Modeling
Presenting Author: Carlos Guimarães

Strategies for Dental & Craniofacial Regeneration

Chairs: Fatima Syed-Picard & Alejandro Almarza
SYIS Co-Chair: Rebecca Byler
Location: Room 618/619/620
Session Topic: Dental & Craniofacial
Description: This session will feature the state of the art in stem cell and tissue engineering-based research focused towards regenerating dental, oral, and craniofacial structures.

Oral Abstract Presentations:
1:30 PM – 1:45 PM | 162 – Development Of A Novel Goat Model For Osteochondral Defects In The TMJ Condyle
Presenting Author: Mairobys Socorro

1:45 PM – 2:00 PM | 163 – Mechanoregulation Of Jaw Adductor Tendon Development
Presenting Author: Catherine Kuo

2:00 PM – 2:15 PM | 164 – Engineered Angulations Of Fibrous Connective Tissues In Periodontal Complexes: The Canine Model
Presenting Author: Chan Ho Park

2:15 PM – 2:30 PM | 165 – The Long Non-coding Rna Igfbp7-as1 Accelerates Stem Cells From Human Exfoliated Deciduous Teeth Odontogenic Differentiation By Regulating Igfbp7 Expression
Presenting Author: Dan Wang

2:30 PM – 2:45 PM | 166 – Enhancing Craniofacial Bone Regeneration: Immunomodulation With Sting Inhibition
Presenting Author: Samar Jalali

2:45 PM – 3:00 PM | 167 – Co-based Artificial Enzyme For ROS Elimination And Periodontitis Treatment
Presenting Author: Yimin Sun

Regenerative Strategies for Musculoskeletal Tissue Regeneration

Chairs: Martijn van Griensven, Andreas Traweger & Alberto Sensini
SYIS Co-Chair: Bibrita Bhar
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description: Injuries and disorders of fibrous connective tissues, such as tendons/ligaments and their junctions, as well as cartilage and menisci, represent one of the major reasons for practice consultations for musculoskeletal pain, impaired function and often require the need of surgery. Both, the general population and athletes are affected resulting in enormous related healthcare costs. Moreover, their treatments are often prone to long rehabilitation times, incomplete functional recovery, and secondary complications after surgery. This session will furnish an overview of the scientific discoveries in the area of these musculoskeletal pathologies, mechanobiology, adaptive and innate immune responses to design innovative therapies such as tissue engineering scaffolds for their more effective structural and functional regeneration. The keynote will address the broad field of fibrous tissues regenerative approaches using biomaterials, cells, and morphogens. The abstracts will be chosen such that a broad spectrum of regenerative solutions is represented.

Keynote Speaker:
1:30 PM – 2:00 PM
Helen Lu

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 168 – Transcriptomics Approach: Investigating The Development And Pathogenesis Of Tendinopathy In A Rat Patellar Model
Presenting Author: Ying Rao

2:15 PM – 2:30 PM | 169 – Genomic Characterization Of Human Meniscus Tissues Reveals Distinct Clusters Of Matrix-producing Cell Subpopulations
Presenting Author: Susana Simmonds

2:30 PM – 2:45 PM | 170 – Injectable, Self-contained, Subaqueously Crosslinking Laminous Adhesives For Biophysical-chemical Modulation Of Osteochondral Microenvironment
Presenting Author: Yuhe Yang

2:45 PM – 3:00 PM | 171 – Biofabrication Of Region-Specific Meniscus Microtissues As Biological Building Blocks To Engineer Anisotropic Meniscal Grafts
Presenting Author: Kaoutar Chattahy

Bioelectronics for Studying Cell/Material Hybrid Interfaces

Chairs: Aaron Lee & Amy Gelmi
SYIS Co-Chair: Jingjing Wu
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: Achieving well-tolerated and chronic biological interfaces remains an ongoing challenge for the deployment of biomedical and bionic devices. The field of tissue engineering and regenerative medicine offers a potentially powerful approach to overcoming or controlling host foreign body reactions and subsequent degradation of device functionality, via improved integration between the ‘bio’ and ‘electronic’. By leveraging our understanding of how to design material systems that can support cell growth and function, we can begin to pursue seamless integration across the abiotic/biotic interface. Our proposed invited speaker, Dr Damiano G. Barone is well placed to speak to the integration of cell-based functional devices as a neurosurgeon and clinical lecturer who has recently published on a hybrid flexible electrode array cultured with induced pluripotent stem cells to form a living interface. It is hoped that this session highlights how our understanding of tissue engineering and regenerative medicine could be used as a toolbox and promote discussion into what challenges need to be overcome in order to translate these transformative technologies to the clinic.

Keynote Speaker:
1:30 PM – 2:00 PM | Biohybrid Neural Interfaces
Damiano Barone, MD, PhD, FRCS

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 172 – A High-throughput In Vitro Platform For Electrical Characterisation Of Biohybrid Electrodes
Presenting Author: Marjolaine Boulingre

2:15 PM – 2:30 PM | 173 – Electroconductive Collagen-pedot:pss Hydrogel For Attenuation Of Post-infarct Cardiac Arrhythmias And Enhancement Of Hipsc-cardiomyocyte Functionality
Presenting Author: Felix Engel

2:30 PM – 2:45 PM | 174 – Overcoming The Blood-brain Barrier: A Novel Approach Using A Conductive Bioadhesive Coating For Voltage-driven Drug Delivery In Glioblastoma Multiforme
Presenting Author: Giovanni Carlo Miceli

2:45 PM – 3:00 PM | 175 – Mxene Functionalized Collagen Biomaterials For Cardiac Tissue Engineering Driving Ipsc-derived Cardiomyocyte Maturation
Presenting Author: Michael Monaghan

RAPID FIRE: Functionalized Biomaterials for Tissue Engineering Applications

Chairs: Golnaz Karoubi & Miguel Oliveira
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials
Description:

Rapid Fire Presentations:
1:30 PM – 1:35 PM | 176 – Supplementation Of Gelma With Taurine Bioink Promotes The Formation Of Myotubes In 3d Printed Scaffolds
Presenting Author: Nima Tabatabaei Rezaei

1:35 PM – 1:40 PM | 177 – Synthetic Matrix Fibers Promote Vascular Assembly In Dense Fibrin Hydrogels
Presenting Author: Firaol Midekssa

1:40 PM – 1:45 PM | 178 – Sustaining Ischemic Tissue Throughout The Healing Process
Presenting Author: Ayden Watt

1:45 PM – 1:50 PM | 179 – Functionalized Silk Matrices For Single- Or Bi-layered Models Of Barrier Tissue
Presenting Author: Savvini Gkouma

1:50 PM – 1:55 PM | 180 – Reinforced biomaterials for tissue regeneration, stem cell fate commitment, and wound healing
Presenting Author: Shabir Hassan

2:00 PM – 2:05 PM | 181 – Engineering Ag-Graphene Oxide Loaded Hydrogel With Robust Photothermal Conversion Efficiency And Synergistically Antibacterial Properties For Promoting Infectious Wound Healing
Presenting Author: Zhiwei Sun

2:05 PM – 2:10 PM | 182 – Mechanotransduction In Magnetic Hydrocups: A Hollow Magnetic Electrospun Scaffold For Hydrogel Stiffening
Presenting Author: Wen Chen

2:10 PM – 2:15 PM | 183 – Synergistic Effects Of Composite Alginate-Gelatin Biopolymeric-Bioactive Glass Scaffold On The In Vitro Osteogenic Potential Of Human Mesenchymal Stem Cells Studied Using Non-invasive Reporters
Presenting Author: Thanusha Av

2:15 PM – 2:20 PM | 184 – Microgels-encapsulated Magnesium/emodin-based Metal Organic Framework Nanorods For Diabetic Bone Regeneration
Presenting Author: Di Wang

2:20 PM – 2:25 PM | 185 – Biofunctionalization Of Bare Metal Stents To Induce Endothelial Colony Forming Cells Recruitment And Reduce Platelet Adhesion In Type 2 Diabetes
Presenting Author: Isra Marei

2:30 PM – 2:35 PM | 186 – Biofabrication Of Granular Hydrogel-based Bioinks For Dermal Regeneration
Presenting Author: Rozalin Shamasha

2:35 PM – 2:40 PM | 187 – Combination of 3d Printing, Plasma Polymerization, and Bioactive Coatings Towards Fabrication of Eggshell Biowaste/Pcl Composite Scaffolds for Bone Regeneration
Presenting Author: Houman Savoji

2:40 PM – 2:45 PM | 188 – Topographical And Fucoidan Modification Of Polyvinyl Alcohol Hydrogel To Enhance Neuronal Neurite Outgrowth And Axon Guidance
Presenting Author: Evelyn Yim

2:45 PM – 2:50 PM | 189 – Antimicrobial Peptide/Chlorin E6 Functionalized Gelma Hydrogels Combined With Photodynamic Therapy Show Strong Antibacterial And Antibiofilm Activity On Resistant Bacteria
Presenting Author: Eda Bilgiç

2:50 PM – 2:55 PM | 190 – Towards Next Generation Implants: Augmentation Of In Vitro Mineralization Via Novel Nanosecond Pulsed Laser Texturing Of Titanium Compared To Standard Sla-treatment
Presenting Author: Denitsa Docheva

Biomaterials for Women’s Health Engineering

Chairs: Brendan Harley & Jennifer Robinson
Location: Room 611/612
Session Topic: Sex, Age and Ancestral Determinants in TERM Research
Description: Women have historically been excluded at all levels of biomedical research and medical device innovation which has led to a gaping hole in the healthcare landscape to meet even the most basic needs in women’s health. To address this critical need, we need innovative biomaterial solutions to expand health technologies available to clinicians to treat women. This session will highlight advances in biomaterial approaches to address the myriad of clinical needs in women’s health. Topics include disorders in reproductive tissues (e.g. endometriosis, cancer, premature ovarian insufficiency, infertility, preterm birth), multicellular tissue-level interactions and mechanics in reproductive health, extracellular matrix dynamics and sex-related differences in chronic diseases and device design, gynecological device design, and breast cancer and reconstruction.

Oral Abstract Presentations:
1:30 PM – 1:45 PM | 191 – Synthetic Poly(ethylene Glycol) Hydrogel Supports Development And Hormone Production Of Dissociated, Reconstructed, And Implanted Human Ovarian Tissue
Presenting Author: Monica Wall

1:45 PM – 2:00 PM | 192 – Scaffold-guided Breast Tissue Engineering – Preclinical Study Of 3D Printed Large Volume Medical-grade Polycaprolactone Scaffolds In A Pig Model
Presenting Author: Ronja Finze

2:00 PM – 2:15 PM | 193 – Modifiable, Biomimetic Polyethylene Glycol (PEG) Hydrogel Enables Co-culture Of Early-stage Ovarian Follicles And Stromal Cells
Presenting Author: Taylor Schissel

2:15 PM – 2:30 PM | 194 – Ovx-induced Bone Loss At Different Skeletal Sites In A Preclinical Model Of Osteoporosis
Presenting Author: Michela Uberti

2:30 PM – 2:45 PM | 195 – Naturally-Derived Electrospun Scaffolds As An Alternative To Surgical Mesh In Women’s Health Applications
Presenting Author: Rebecca Thomson

2:45 PM – 3:00 PM | 196 – In Vivo Performance Of Angiogenic/antibacterial Tissue Interposition Flap Substitute For Use In Vesicovaginal Fistulae Repair
Presenting Author: Kezban Ulubayram

Cell Secretome: Implications in Regenerative Medicine and Aging

Chairs: Roberta Tasso & Roberto Narcisi
SYIS Co-Chair: Andréa Tremblay
Location: Room 606/607
Session Topic: Stem Cell Therapies, Developmental Biology and Cell Signaling
Description: For this symposium we have selected a team of 2 young PIs (one male and one female) and one keynote speaker (an internationally recognized expert in the field of cell secretome and senescence), overall representing 3 different universities in 3 different European nations (all TERMIS members).
Presentations and discussions would focus on: i) the identification, characterization, and functional roles of secreted factors in intercellular communication, tissue homeostasis, and disease pathogenesis; ii) extracellular vesicles (EVs), with the aim of delving into the biology, biogenesis, and functions of EVs. Topics would include the cargo carried by EVs, their roles in cell-to-cell communication, tissue regeneration, immune modulation, and their potential as diagnostic and therapeutic tools; iii) senescence, with particular focus to the molecular mechanisms underlying senescence, the impact of senescent cells on tissue homeostasis and inflammation, and potential strategies to modulate senescence for therapeutic purposes.

Keynote Speaker:
1:30 PM – 2:00 PM | Senescent cell secretomes and how to get rid of them
Johannes Grillari, PhD

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 197 – Engineered Extracellular Vesicles For Targeting And Activation Of Lymphatic Vegfr-3
Presenting Author: Johannes Oesterreicher

2:15 PM – 2:30 PM | 198 – Extracellular Vesicles Derived From Induced Msc (imsc) And Chondrocytes (icho): Evaluation Of Anti-inflammatory Effects Using An In Vitro Osteoarthritis Model
Presenting Author: Chiara Gentili

2:30 PM – 2:45 PM | 199 – Stress-Induced Premature Senescence And Senolytic Intervention For Therapeutic Implications In The Adipose Stromal Vascular Niche
Presenting Author: Marlene Wahlmueller

2:45 PM – 3:00 PM | 200 – Enhancing Targeted Regeneration Of Peripheral Nerves Via Laminin-binding Extracellular Vesicles Derived From Adipose Tissue-derived Stem Cells
Presenting Author: Mai Nguyen

Translating Tissue Engineering Research to the Clinic: A Latin American Experience

Chairs: Maria Coronel & Marta Fontanilla Duque
Location: Room 602/603/604
Session Topic: Special Session
Description: Panel discussion focused on the Latin American experience in translating tissue engineering research into clinical practice. Includes discussion on student mentoring, research support from government and private resources, as well as the creation of biotech spin off companies. This session targets faculty and students both currently doing or with an interest in collaborating with the tissue engineering community in Latin America.

Panelists:
Carolina Centeno Cerdas
Juan Carlos Briceño Triana
Patricia Pranke
Riccardo Beltran

Mitochondrial Transplantation: The Dawn of a New Era. A session sponsored by the Cell Transplant and Regenerative Medicine Society

Chairs: Giuseppe Orlando & Lorenzo Moroni
Location: Room 608/609
Session Topic: Special Session
Description: There are several common traits between the respiratory, gastrointestinal, and urogenital systems: all comprise relatively large tubular structures that are subject to fluid flow and peculiar loads, and all are “interface” systems between drastically different environments where physiologically crucial transport phenomena occur. Hence, notwithstanding the specificities of each system, there are common challenges when trying to engineer or regenerate each of them. In this session, we will be discussing recent advances in the tissue engineering and regenerative medicine of the airways and of the digestive and urogenital systems, identifying key lessons that could be leveraged across structures and functions, while highlighting the unique challenges of each physiological environment.

Panelists:
1:30 PM – 1:45 PM | Mitochondrial Transplantation To Minimize Organ Discard and Increase the Donor Pool
Amish Asthana

1:45 PM – 2:00 PM | Mitochondrial Transplant for Acute Ischemic Stroke: First in Human Trial
Melanie Walker

2:00 PM – 2:15 PM | Mitochondria: can the center piece of metabolism be fixed when it is broken?
Russell Saneto

2:15 PM – 2:30 PM | Delivery of mitochondria-containing EVs to the blood-brain barrie
Devika Soundara Manickam

2:30 PM – 3:00 PM | Panel Discussion

3:00 PM – 3:15 PM | Transitional Break

3:15 PM – 4:45 PM | Scientific Concurrent Session 5
Multicellular Models of the Tumor Microenvironment

Chairs: Eirini Velliou & Panagiotis Mistriotis
SYIS Co-Chair: Rory Long
Location: Room 608/609
Session Topic: Cancer
Description: Recently, it has become increasingly evident that biomechanical, biophysical, biochemical, topographical and cellular components of the cancer tissue environment interact in complex ways, leading to the progression of the disease and affecting the treatment response and the metastatic potential. To that end, cancer models are of paramount importance in understanding the disease mechanisms, in new therapy development as well as for personalised treatment screening. Tissue Engineering has revolutionized the field by enabling the generation of sophisticated and intricate models. This symposium will be discussing the latest developments in advanced, complex 3D models of cancer. We welcome abstracts related to organoids and novel scaffold based approaches for modelling cancer and its’ tissue environment including composite scaffolds, 3D-bioprinting approaches, bioreactor, micro-reactor and micro-fluidics work as well as abstracts involving treatment screening. Work involving spatial and temporal mapping of biophysical and cellular features of the tumour microenvironment is of particular interest.

Keynote Speaker:
3:15 PM – 3:45 PM | Determining Cancer Recurrence Mechanisms using Engineered Tissue Models
Marjan Rafat, PhD

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 202 – Using 3d Tumoroids At The Air-liquid Interface To Find A New Tool For Monitoring Treatment Outcomes In Non-small-cell Lung Cancer Patients
Presenting Author: Dania Movia

4:00 PM – 4:15 PM | 203 – Patient-Derived Organotypic Colorectal Tumor Model To Study Tumor-stromal Interactions
Presenting Author: Hossein Tavana

4:15 PM – 4:30 PM | 204 – Engineering 3-dimensional Assembloid Platforms To Investigate Fibroblast-cancer Cell Crosstalk And Its Role In Colorectal Cancer Metastasis
Presenting Author: Esther Sim

4:30 PM – 4:45 PM | 205 – Multiplex Single-Cell Bioprinting For Engineering Heterogeneous Tissues With Subcellular Spatial Precision
Presenting Author: Haylie Helms

Vascularization in Tissue Engineering – Session II

Chairs: Bin Jiang & Brandon Tefft
SYIS Co-Chair: Nataliia Shchotkina
Location: Room 606/607
Session Topic: Cardiovascular/Angiogenesis/Blood
Description: A major challenge in engineered tissues with three-dimensional (3D) architecture has been the generation of functional microvasculature to deliver oxygen and nutrients and to remove waste. Strategies include patterning of vessel structures, seeding of cells that promote neovascularization, promotion of angiogenesis from the host, cell self-assembly, and in vivo tissue engineering. Additionally, vascularization is needed to advance 3D in vitro tissue models, which have emerged as valuable tools for longitudinal studies on tissue development, function, and disease progression. This session will focus on new and emerging research to vascularize a variety of engineered tissues both in vitro and in vivo. Studies testing functional interactions between engineered vessels and engineered tissues are especially encouraged. It will also explore the cutting-edge research and breakthroughs in the field of vascularization within 3D in vitro models, including strategies for recapitulating vascular complexity, the role of vascularization in tissue development and functionality, and the use of vascularized models in studying diseases and testing therapeutic interventions.

Oral Abstract Presentations:
3:15 PM – 3:30 PM | 206 – Advanced 3D Model Of The Neurovascular Unit And Blood-brain Barrier Using Ex Vivo Human Brain Tissue To Model Neurovascular Pathologies
Presenting Author: Brian O’Grady

3:30 PM – 3:45 PM | 207 – Production Of Vascularized Functional Liver Tissue Constructs With Long-term Survival
Presenting Author: Kelsey Willson

3:45 PM – 4:00 PM | 208 – Development Of A 3d Bioprinted Vascularized Thick Liver Construct For Spaceflight Testing
Presenting Author: Timothy Dobroski

4:00 PM – 4:15 PM | 209 – Characterization Of Micro-vascularization And Hepatic Function In FRESH 3D Bioprinted Liver Lobule-mimicking Scaffolds
Presenting Author: Ali Asghari Adib

4:15 PM – 4:30 PM | 210 – Hydrogel Optimisation For Evaluation Of Angiogenic Responses In 3d Tissue Models Containing Perfusable Microvascular Networks
Presenting Author: Robin Dai

4:30 PM – 4:45 PM | 211 – Enhanced Vascularization Of Brain Organoids: Towards A User-convenient And Reproducible Protocol
Presenting Author: Josep Fumadó Navarro

Computational Modelling for Tissue Engineering

Chairs: Ishita Jain & Giovanni Vozzi
SYIS Co-Chair: Maitraee Mistry
Location: Room 611/612
Session Topic: Computational Approaches for Tissue Engineering
Description: Computational modeling and machine learning can enhance our ability to design and evaluate new tissue engineering strategies for a variety of applications. This is especially important in contexts such as cardiovascular or lung TE, where the myocardium and lungs undergo immense variations in blood pressure and volume, leading to significant variations at cellular level microenvironment that is relevant to any tissue engineered product in vivo. This session will explore computational approaches and tools for tissue engineering, including predictive modeling for bioprinting/biofabrication, evaluating complex data from in vitro and in vivo studies, and predicting the performance of therapeutics in different environments. Examples of these may include fluid mechanics and bio-transport models of drug/protein delivery, patient-specific biomechanical modeling, models of protein-protein and protein-material interactions, statistical modeling for therapeutic optimization, machine learning for the design, quality controlled fabrication and analysis of tissue engineering products, machine learning for histological analysis, and bioinformatics-based platforms for analyzing complex data, including RNA sequencing and other -omics approaches.

Keynote Speaker:
3:15 PM – 3:45 PM | Quantitative image analysis and machine learning to enhance label-free optical microscopy for applications in tissue engineering
Alex Walsh, PhD

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 212 – Mapping Patient-Specific Histological Architecture To Divergent Cellular Niches In Pancreatic Ductal Adenocarcinoma
Presenting Author: Jason Guo

4:00 PM – 4:15 PM | 213 – A Digital Twin To Determine The Pericellular Biochemical Microenvironment Seen By The Spheroids Cultured In A Perfusion Bioreactor
Presenting Author: Soukaina El Hajj

4:15 PM – 4:30 PM | 214 – Artificial Intelligence For Quality Control And Parameter Optimization In Extrusion Based Bioprinting
Presenting Author: Carmelo De Maria

4:30 PM – 4:45 PM | 215 – Vip Cells: Screening Key Players And Calculating Their Contributions In Cardiovascular Tissue Remodeling And Regeneration With Supervised Learning
Presenting Author: Jonghyeuk Han

Scalability of Cartilage and Bone Tissue Production: Where Size Matters

Chairs: Debby Gawlitta & Tim Woodfield
SYIS Co-Chair: Emi Kiyotake
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description: Cartilage and bone defects present significant clinical challenges, driving the need for effective regenerative strategies. Recent progress in tissue engineering technologies offers the opportunity to generate large three-dimensional (3D) constructs. To generate centimeter-scale tissues, several scalability challenges arise: expanding billions of cells, generation and maintenance of complex shapes, nutrient supply, intense manual labor, and reproducibility. This symposium will cover key approaches to dealing with scalability of 3D tissue production, particularly bone and cartilage. Emerging technologies that address scalability include biofabrication, robotics, bioreactor systems, scaffold/construct design, and vascularization. A special emphasis will be on bottom-up approaches that use microtissue building blocks to realize large structures. In conclusion, upscaling microtissue production and controlling their assembly into large complex structures holds immense potential in regenerative medicine.

Keynote Speaker:
3:15 PM – 3:45 PM | End-to-end automation for scalable organoid-based skeletal implant biomanufacturing: from micro to Macro
Prof. Ioannis Papantoniou

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 216 – Scalable Spheroid Biofabrication Platforms For Musculoskeletal Regenerative Medicine And Disease Modelling
Presenting Author: Tim Woodfield

4:00 PM – 4:15 PM | 217 – Biofabrication Of Large Articular Cartilage Grafts With Zonal Organization Using Microtissues Primed In Altered Oxygen Conditions
Presenting Author: Nadia Rodriguez

4:15 PM – 4:30 PM | 218 – Engineering Zonated Osteochondral Assembloid Implants With Cartilaginous µTissues For The Regeneration Of Joint Defects
Presenting Author: Liuqi Peng

4:30 PM – 4:45 PM | 219 – Upscaling Manufacture Of Osteogenically Differentiated Mesenchymal Stem Cells Using Nanoscale Vibration And Microcarrier Suspension Culture
Presenting Author: Jonathan Williams

Neuroengineering Strategies in TERM

Chairs: Nisha Iyer & Jessica Butts
SYIS Co-Chair: Dzana Katana
Location: Room 615/616/617
Session Topic: Neural & Spine
Description: Modeling and regeneration of the nervous system remains a unique challenge for biomedical scientists and engineers stemming from need to replicate or restore intricate architecture and functional complexities. This session will highlight recent advances in neural tissue engineering approaches for the peripheral and central nervous systems, including innovations at the convergence of advanced biomaterials, stem cell technologies, and innovative fabrication techniques. Discourse is intended to unveil novel avenues in addressing challenges posed by neurodegenerative diseases and neural traumas, paving the way for new therapeutic strategies.

Oral Abstract Presentations:
3:15 PM – 3:30 PM | 220 – Injectable Hydrogel Comprising MicroRNAs Promotes Nerve Regeneration Following Brain Stroke
Presenting Author: Ruby Singh

3:30 PM – 3:45 PM | 221 – Co-delivery Of A Thermostabilized Enzyme And Human Neural Progenitor Cells Using Tailored Hydrogels Enhances Recovery After Stroke
Presenting Author: Nitzan Letko Khait

3:45 PM – 4:00 PM | 222 – Electrostimulation Via A 3D-printed, Biomimetic, Neurotrophic, Electroconductive Scaffold For The Promotion Of Axonal Regrowth After Spinal Cord Injury
Presenting Author: Liam Leahy

4:00 PM – 4:15 PM | 223 – Motor Function Evaluation Of A Prevascularized Cell-based Tissue-engineered Nerve Tube In Rabbit Nerve Defect Regeneration
Presenting Author: Alexane Thibodeau

4:15 PM – 4:30 PM | 224 – Automated Production Of Nerve Repair Constructs Containing Endothelial Cells Derived From Human Induced Pluripotent Stem Cells
Presenting Author: Poppy Smith

4:30 PM – 4:45 PM | 225 – A Cell-derived Extracellular Matrix-based Biologic To Reverse Axonal Degeneration In Diabetic Neuropathy
Presenting Author: Zhamilya Zhirenova

Regenerative Rehabilitation: Connecting Basic Science and Clinic

Chairs: Kai Wang & Akira Ito
SYIS Co-Chair: Louis Chen
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: This session will focus on introducing Regenerative Rehabilitation, a cross-disciplinary field that combines tissue engineering and regenerative medicine with applied biophysics and tissue/organ-specific rehabilitation approaches to enhance tissue repair and function outcomes. Aligning with TERMIS’s goal of advancing tissue engineering & regenerative medicine to improve patient outcomes, this regenerative rehabilitation session will help increase communication and collaboration between the fields of tissue engineering and rehabilitation science. In this session, we have invited Dr. Fabrisia Ambrosio, the founding director of the Alliance for Regenerative Rehabilitation Research and Training (AR3T) and an Associate Professor at Harvard Medical School and Spaulding Rehabilitation Hospital, to give an overview of the regenerative rehabilitation field, regenerative rehabilitation research, and funding opportunities. Four other speakers selected from submitted abstracts will share their innovative research in regenerative rehabilitation during the session.

Keynote Speaker:
3:15 PM – 3:45 PM | Applied biophysics meets stem cell therapeutics
Fabrisia Ambrosio, PhD, MPT

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 226 – Age-associated Functional Healing Of Musculoskeletal Trauma Through Regenerative Engineering And Rehabilitation
Presenting Author: Karina Nakayama

4:00 PM – 4:15 PM | 227 – Muscle Contraction Training Promotes Efficiency Of Ips Cell-derived Muscle Stem Cell Transplantation In A Mouse Model Of Duchenne Muscular Dystrophy
Presenting Author: Nana Takenaka-Ninagawa

4:15 PM – 4:30 PM | 228 – Electrical Stimulation Via Conducting Polymers For Neural Repair
Presenting Author: Shang Song

4:30 PM – 4:45 PM | 229 – Decoupling The Biochemical And Mechanical Effects Of Muscle Exercise On Motor Neuron Growth And Remodeling
Presenting Author: Angel Bu

Supercritical Fluid Technology for Scaffold Fabrication & Sterilization

Chairs: Aaron Strickland & Jordan Roe
Location: Room 618/619/620
Session Topic: Special Session
Description: With the rapid growth of innovations in Tissue Engineering and Regenerative Medicine, the application of
greener processes and the ability to sterilize complex biomaterials is an increasingly important consideration, best recognized early in the research process. Supercritical fluid technologies can address challenges in environmentally responsible bioprocessing, decellularization and sterilization of complex or bioactive biomaterials. This session aims to increase awareness of supercritical carbon dioxide (scCO2) utility, scCO2-based biological scaffold fabrication approaches, and the challenges encountered along regulatory approval pathways.

Speakers:
3:15 PM – 3:45 PM | Harnessing the properties of supercritical fluids for biomaterial fabrication
Lisa White

3:45 PM – 4:15 PM | Utilizing supercritical fluid as sterilization process for biomaterials
Helen Berry

4:15 PM – 4:30 PM | Decellularised heart valves: structure and function following sterilization by scCO2
Amisha Desai

4:30 PM – 4:45 PM | Question & Answer

From Lab to Market: Empowering Tissue Engineering Entrepreneurship for Regenerative Breakthroughs

Chairs: Marcella Vaicik
Location: Room 602/603/604
Session Topic: Special Session
Description: Join us in this symposium as we delve into the captivating journeys of pioneering tissue engineering entrepreneurs. With a shared vision to bridge the gap between scientific advancements and market demand, these entrepreneurs have embarked on the path of establishing startups, securing funding, navigating regulatory processes, and scaling their businesses. By synergizing scientific expertise, business acumen, and a profound understanding of the healthcare industry, they strive to drive innovation and make a tangible impact on patient care and the realm of regenerative medicine.

Panelists:
3:15 PM – 3:30 PM | Moving the Nozzle in Healthcare
Nicole Black

3:30 PM – 3:45 PM |
Thomas Gilbert

3:45 PM – 4:00 PM | Translating Discovery into Next-Generation Therapies by Bridging Academia and Entrepreneurship
A.J. Mellott

4:00 PM – 4:45 PM | Panel Discussion

RAPID FIRE: Next Generation Biomaterials in TERM

Chairs: Jeroen van den Beucken
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials

Rapid Fire Presentations:
3:15 PM – 3:20 PM | 230 – De Novo Organs For Drug Discovery, Cell Therapy Development And Transplantation
Presenting Author: Yvonne Ping

3:20 PM – 3:25 PM | 231 – Decellularization Of Whole Rat Kidneys: Application Of Physical And Chemical Methods
Presenting Author: Haitham Salti

3:25 PM – 3:30 PM | 232 – New Engines For Polybiosensing And Analysis Of Growing Cells: From Disease Models To Therapeutic Strategies
Presenting Author: Mandana Veiseh

3:30 PM – 3:35 PM | 233 – Hydrogel Delivery Of MicroRNA:nanoparticle Complexes Enhances Osteogenesis In MSC-laden 3D Hydrogels
Presenting Author: Jess Frith

3:35 PM – 3:40 PM | 234 – Electrical Stimulation Via Temporal Interference For CNS Repair
Presenting Author: Shirine Merlo-Nikpay

3:40 PM – 3:45 PM | 235 – Surface Functionalization Of Polidimetilxilosane For Organ-on-a-chip
Presenting Author: Mitzi Pérez Calixto

3:50 PM – 3:55 PM | 236 – Harnessing DNA Hybridization To Engineer A Novel Dynamic Biointerface With Tunable RGD Kinetics At Nanoscale To Influence Stem Cell Fate
Presenting Author: Xingzhen Zhang

4:00 PM – 4:05 PM | 238 – Development Of Bifunctionalized Microcarriers For The Isolation, Culture And Ex Vivo Expansion Of Endothelial Progenitor Cells
Presenting Author: Marc-Antoine Campeau

4:05 PM – 4:10 PM | 239 – Towards Seamless, Biomimetic, Bioactive Multi-channel Peripheral Nerve Guidance Conduits Made Of Silk Fibroin Nanofibres
Presenting Author: Diego Torres

4:15 PM – 4:20 PM | 240 – In Vitro Immunomodulation Of An Inflammatory Osteoarthritic Model With Sustained Release Of Curcumin From A Dual Crosslinked Photocurable Injectable Polymeric Nanoparticulate Composite System
Presenting Author: Anwesha Mukherjee

4:20 PM – 4:25 PM | 241 – Innovative Cartilage Regeneration Via 3d-bioprinted Personalized Implants Of Human Adscs Loaded Gelma Hydrogels
Presenting Author: Jasmin Hunsrucker

4:25 PM – 4:30 PM | 242 – Aligned Hyaluronic Acid-Coated Polycaprolactone Melt Electrowritten Scaffolds For Muscle Repair
Presenting Author: Alycia Galindo

4:30 PM – 4:35 PM | 243 – Contact Drawn Biosynthetic Collagen Fiber Scaffolds Drive Anisotropic Cellular Organization For In Vitro Models
Presenting Author: Gurkaran Chowdhry

4:35 PM – 4:40 PM | 244 – Nucleic Acid-Collagen Complexes: Unveiling Hierarchical Assembly And Physicochemical Characteristics Towards Advanced Tissue Engineering
Presenting Author: Nikolaos Pipis

RAPID FIRE: Biofabrication

Chairs: Andrea Vernengo & Michael Rotherham
Location: Ballroom 6E
Session Topic: Biofabrication
Description:

Rapid Fire Presentations:
3:15 PM – 3:20 PM | 245 – An Open-source Approach To Accelerate Emerging Biofabrication Technologies
Presenting Author: Iman von Briesen

3:20 PM – 3:25 PM | 246 – High-throughput Bioprinting For Intraoperative Regeneration Of Scalable Human Tissues
Presenting Author: Yogendra Pratap Singh

3:25 PM – 3:30 PM | 247 – Scaling, Automating And Closing The Manufacturing Of A Subretinal Tissue Construct
Presenting Author: Sarah Piet

3:30 PM – 3:35 PM | 248 – Robotic-based In Situ Bioprinting Of Photo-curable Biomaterials Onto Complex Anatomical Defects
Presenting Author: Giovanni Vozzi

3:35 PM – 3:40 PM | 249 – Light-Pipe FRESH 3D Bioprinting for Engineering Spatially Heterogeneous Tissue Scaffolds
Presenting Author: Caner Dikyol

3:45 PM – 3:50 PM | 250 – Development Of A Novel Extrusion-based 3d-printing Method: Dragging Technique And Its Application To Tubular Tissue Engineering
Presenting Author: Jae-Seok Kim

3:50 PM – 3:55 PM | 251 – Spatially Guided Construction Of Multilayered Skin Models Recapturing Structural Hierarchy And Cell-cell Junctions
Presenting Author: Fanben Meng

3:55 PM – 4:00 PM | 252 – Patterning And Controlled Compaction Of Cells Embedded Within Thermosensitive Hydrogels For Anisotropic Tissue Engineering
Presenting Author: Athanasia Pylostomou

4:00 PM – 4:05 PM | 253 – 3d Printing Of Honeycomb-mimetic Scaffold With Robust Ros-scavenging, Antibacterial, Angiogenesis, And Osteogenesis Properties For Infectious Bone Defect Repair
Presenting Author: Xiangru Chen

4:05 PM – 4:10 PM | 254 – Biofabrication Of A Biomimetic Vocal Fold Microtissue
Presenting Author: Luis Medina

4:15 PM – 4:20 PM | 255 – Quadruple Culture Of Primary Human Osteoblasts, Osteocytes, Osteoclasts And Endothelial Cells – An Advanced 3D Bone Model
Presenting Author: Katharina Wirsig

4:20 PM – 4:25 PM | 256 – Fabrication Of A Giant Spheroid With Pumping System
Presenting Author: Nobuhiko Kojima

4:25 PM – 4:30 PM | 257 – Multi-axis Melt Electrowriting For Out-of-plane Biotextile Fabrication
Presenting Author: David Dean

4:30 PM – 4:35 PM | 258 – Sacrificial-free Direct Ink Writing: A Versatile Approach For Bioprinting Perfusable Organ Models
Presenting Author: Dongwei Wu

4:35 PM – 4:40 PM | 259 – Electrospun Aligned Nanofiber Yarns Constructed Biomimetic M-type Interface Integrated Into Precise Co-culture System As Muscle-tendon Junction-on-a-chip For Drug Development
Presenting Author: Ting Li

4:45 PM – 5:15 PM | Networking Coffee Break in Exhibit Hall

Location: Hall 4A
Meet with exhibitors to learn about their services and products.

4:50 PM – 5:05 PM | Medical innovation in 3D printing from nature’s toolbox

Sponsored by: Viscofan
Location: Hall 4A
Speaker:

As a central structural protein, collagen provides strength and elasticity in all animal connective tissues. Nature has therefore retained the basic structure of this important building material over the course of evolution: A triple helix of three polypeptide strands with a firmly defined amino acid sequence. The cross-linking of these tau-like fibres forms a scaffold for cells in the body as a prerequisite for the formation and regeneration of tissue. Medicine uses collagen as a biomaterial for the treatment of damaged organs, e.g. as an implant membrane. The protein can be easily customised for different applications by manipulating its physical, chemical and biological properties. Collagen gel plays an important role as an ‘ink’ in the development of 3D printing processes in biomedicine for the production of matrices, tissue and organ models.

The Fibercoll-Flex® bioink family are collagen bioinks that do not require stabilisation with methacrylate curing. At an acidic pH (2.0 – 3.0), native collagen has a maximum gel viscosity with even distribution of the fibres and homogeneous flow properties. For 3D printing of self-supporting models, collagen type I fibres with a length of 200-800 µm and a diameter of 20 µm are used, which have optimal structural-viscous behaviour. The stability is influenced by the collagen concentration, among other things. After printing, living cells can grow into the carrier structure, which then serves as artificial tissue, e.g. for pharmaceutical screenings. With Fibercoll-Flex®-A, Viscofan has developed an acidic collagen gel for models with a viscosity between 2 – 10 kPa.

3D printing with cells leads directly to an ‘animated’ tissue model, but is a real challenge as the shear force can damage the sensitive membranes and printing requires physiological conditions (neutral pH, 37°C). With Fibercoll-Flex®-N, Viscofan offers a bio-ink that is pH-neutralised and mixed with living cells before use. Printing takes place at 20-37°C and produces models with a strength of 0.2 – 0.9 kPa.

As the FibercollFlex bioinks do not require cross-linking, the printed models are therefore particularly biocompatible and offer optimal conditions for cell adhesion and growth as ‘in vivo’-like carrier structures. As an innovative printing material for the production of tissue models, Fibercoll-Flex® collagen inks therefore have great potential for new applications in regenerative medicine.

5:15 PM – 6:15 PM | Debate Session: What Drives Transformative Progress in Regenerative Medicine: People or Technology

Location: Ballroom 6 B/C

Moderator: Robert E. Guldberg

Speakers:
Molly Stevens
Dietmar W. Hutmacher

6:15 PM – 6:30 PM | WFIRM Awards Presentation

Location : Ballroom 6 B/C

2024 Award Recipients:
David Johnson
Feini Qu

6:30 PM – 8:00 PM | Poster Session II

Location: Hall 4A
Meet with exhibitors to learn about their services and products. Check out the great science in the poster presentations. Take time to meet with the authors and discuss their findings. Light appetizers and beverages will be served.

6:25 PM – 6:40 PM | Accelerate Next-Gen Therapies, Personalized Medicine with 3D Bioprinted Hydrogels

Sponsor: B9Creations
Speakers: B9Creations CEO Shon Anderon & Ronawk Co-Founder & CEO AJ Melott
Location: Hall 4A

Join us for an exciting presentation on the revolutionary Bio-Blocks® technology, developed by Ronawk and powered by B9Creations technology! Discover how Bio-Blocks® provide 3D micro-environments for cells to expand organically and continuously without subcultures, leading to high-quality tissue that can transform biological therapies, diagnostics, and research. Learn how this innovative approach overcomes the limitations of traditional plasticware and gel-based scaffolds, providing unparalleled support for cell growth and real-time analysis. Delve into the intricacies of 3D scaffolds, where the standard often falls short in precision and consistency. Explore how B9Creations’ cutting-edge technology is revolutionizing this field, offering unparalleled uniformity and reproducibility in 3D-printed Bio-Blocks®. Discover the game-changing advantages Ronawk harnesses through B9Creations’ capabilities and explore the future of tissue engineering and cell cultivation while hearing how B9Creations’ breakthrough platform accelerates drug discovery and the development of tailored therapies. Don’t miss this opportunity!

6:45 PM – 7:00 PM | Next-Generation Bioprinting (NGB) Platform: Leveraging the Capabilities for the Translation of Bioprinting Procedures to Clinic

Sponsor: Scintica
Moderator: Niloufar Khosravi, PhD
Speaker: Fabien Guillemot, PhD
Location: Hall 4A

To address the limitations of current tissue engineering methods and fulfill unmet clinical needs, the Next-Generation Bioprinting (NGB) Platform is designed to combine the advantages of Laser-Assisted Bioprinting (LAB) technology—such as high resolution and enhanced cell viability— with other bioprinting technologies like bioextrusion. This integration enables the fabrication of complex multi-cellular 3D constructs. Featuring robotic automation and innovative fluidics devices, the NGB platform enables transition of the bioprinted products from the laboratory to clinic. The commercial NGB-R system is designed for developing bioprinting procedures at the preclinical stage that are translatable to the clinical-ready NGB-C system. This system complies with Good Manufacturing Practices (GMP) for Advanced Therapy Medicinal Products (ATMPs). In this presentation, we will showcase this translation capacity through our first bioprinted tissue therapeutics including skin and cartilage, that are being developed using the NGB platform.

7:05 PM – 7:20 PM | Macroporous Alginate Foam Scaffolds for 3D Cell Growth

Sponsored by: IFF
Location: Hall 4A
Speaker: Mark Dreibelbis, Senior Scientist

Biopolymer-based hydrogel scaffolds can serve as 3D cell growth environments which enable attachment and proliferation in a biologically meaningful environment. In this study, an alginate-based porous foam scaffold was produced through mechanical aeration and slow internal gelling followed by casting and drying for use as 3D cell culture scaffolds. Cell growth will be demonstrated in murine fibroblasts (NIH3T3) among other model cell types. Cells were immobilized within the foam hydrogel by in-situ gelation with either ultrapure (UP) alginate or UP alginate with coupled GRGDSP peptide sequence. Using fluorescence microscopy, cell proliferation and spheroid formation were observed across a range of cell densities and alginate concentrations, where both lower alginate density and lower cell seeding density encouraged NIH3T3 proliferation and reorganization into larger cell structures. Larger structures with elongated cell morphology were seen in peptide-coupled alginate conditions, where cell structures colocalized with foam scaffold pores. Alginate-based foam scaffolds can achieve consistent encapsulation of cells in a defined alginate network. Modulation of alginate concentration and peptide moieties influences cell response in these networks, where tailoring these properties can aid efforts in tissue engineering and therapeutic screening.

Thursday, June 27

Day 3: Thursday, June 27

7:00 AM – 7:30 PM | Registration Desk Open

The registration desk will be located in the Atrium on the Fourth Floor of the Seattle Convention Center Arch Building.

7:00 AM – 6:00 PM | Speaker Ready Room Open

Location: Room 613

Speakers should check-in at the speaker ready room at least 2 hours prior to their session start time. Staff will be on hand to answer questions about av setup in presentation rooms and assist with any presentation edits.

8:00 AM – 9:30 AM | Scientific Concurrent Session 6
Multicellular Models of the Tumor Microenvironment – Session II

Chairs: Eirini Velliou & Panagiotis Mistriotis
SYIS Co-Chair: Andrea Bezze
Location: Room 608/609
Session Topic: Cancer
Description: Recently, it has become increasingly evident that biomechanical, biophysical, biochemical, topographical and cellular components of the cancer tissue environment interact in complex ways, leading to the progression of the disease and affecting the treatment response and the metastatic potential. To that end, cancer models are of paramount importance in understanding the disease mechanisms, in new therapy development as well as for personalised treatment screening. Tissue Engineering has revolutionized the field by enabling the generation of sophisticated and intricate models. This symposium will be discussing the latest developments in advanced, complex 3D models of cancer. We welcome abstracts related to organoids and novel scaffold based approaches for modelling cancer and its’ tissue environment including composite scaffolds, 3D-bioprinting approaches, bioreactor, micro-reactor and micro-fluidics work as well as abstracts involving treatment screening. Work involving spatial and temporal mapping of biophysical and cellular features of the tumour microenvironment is of particular interest.

Oral Abstract Presentations:
8:00 AM – 8:15 AM | 260 – Chemotherapeutic Assessment On A Novel, Dynamic, Multicompartment, Multicellular Pancreatic Cancer Model: Towards Engineering Of Personalised Tools For Cancer Treatment Screening
Presenting Author: Eirini Velliou

8:15 AM – 8:30 AM | 261 – Defining A Gene Signature To Augment Patient Stratification Using An Engineered Model Of Patient-derived Pancreatic Cancer Cells And Primary Macrophages
Presenting Author: Alison McGuigan

8:30 AM – 8:45 AM | 262 – Bioengineered Hydrogels For Enhanced Patient-derived Tumor Explant Culture
Presenting Author: Eliza Li Shan Fong

8:45 AM – 9:00 AM | 263 – Delineating The Role Of Bone Marrow Adipocytes And Therapy Response On Metastatic Prostate Cancer Growth Using Humanized 3d Coculture Platforms In Vitro And In Vivo
Presenting Author: Agathe Bessot


9:00 AM – 9:15 AM | 264 – Glioblastoma-neuroimmune Platform For Proinflammatory Glia Transformation Via Glutamate/C3 Activity
Presenting Author: Yen N. Diep


9:15 AM – 9:30 AM | 265 – 3D Bio-printed Immune-responsive Microtissues To Develop Patient-specific Non-animal Technologies (NAT) In Leukaemia Drug Development
Presenting Author: Sean Hockney

Tissue Engineered Heart Valves, Vascular Grafts and Cardiac Tissue

Chairs: Robert Tranquillo & Stefan Jockenhoevel
SYIS Co-Chair: Ziyu Wang
Location: Room 615/616/617
Session Topic: Cardiovascular/Angiogenesis/Blood
Description: This session will focus on novel designs for heart valves, vascular grafts, and cardiac tissue based on regenerative materials and pluripotent cells.

Oral Abstract Presentations:
8:00 AM – 8:15 AM | 266 – Platelets Are A Key Driver Of LYST-mediated TEVG Stenosis
Presenting Author: Mackenzie Turner

8:15 AM – 8:30 AM | 267 – Biologically-engineered Valved Conduits For Rvot Repair Evaluated For 52 Weeks In Growing Lambs
Presenting Author: Robert Tranquillo

8:30 AM – 8:45 AM | 268 – Rapamycin-eluting Tissue-engineered Vascular Graft: A Solution For Inflammation-induced Subacute Narrowing
Presenting Author: Tatsuya Watanabe

8:45 AM – 9:00 AM | 269 – Microfabricated Anisotropic Cardiac Myobundles For The Modular Assembly Of Cardiac Tissue Grafts
Presenting Author: Maggie Jewett


9:00 AM – 9:15 AM | 270 – Generation Of Universal Hipscs And Their Differentiation Into Cardiomyocytes
Presenting Author: Tzu-Cheng Sung


9:15 AM – 9:30 AM | 271 – Micro-RNA Mediated Reprogramming Of Human Cardiac Fibroblasts Into Induced Cardiomyocytes Via Bioengineering Strategies In Vitro And In Vivo
Presenting Author: Valeria Chiono

Emerging Applications of Ultrasound in Regenerative Medicine

Chairs: Nicholas Evans & Carolyn Schutt Ibsen
SYIS Co-Chair: Matthias Kollert
Location: Room 618/619/620
Session Topic: Imaging and Assessment
Description: This session will cover applications of ultrasound in tissue engineering and regenerative medicine. Ultrasound has historically been used in diagnostic imaging and tissue ablation but in the past few years, exciting new applications of ultrasound have emerged. For example, the pressure fields that ultrasound creates exerts controlled radiation forces that can remotely pattern cell populations for the assembly of engineered tissues. Ultrasound can also be used to trigger catalysis, instigate gelation, and stimulate cellular processes important for tissue repair and regeneration. Ultrasound has also been used to image gene expression using acoustic reporter genes and harnessed to stimulate site-specific drug and gene delivery, often aided by ultrasound contrast agents (e.g., microbubbles). This session aims to show some of the state of the art in the use of ultrasound in the field of regenerative medicine.

Keynote Speakers:
8:00 AM – 8:30 AM | Talking to Cells: Biomolecular Ultrasound for Deep Tissue Imaging and Control of Cellular Function
Mikhail G. Shapiro

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 272 – Ultrasound-responsive Engineered Tissue Constructs For Remote Genetic Manipulation Of Cell Signaling
Presenting Author: Carolyn Schutt Ibsen

8:45 AM – 9:00 AM | 273 – Investigating Dural Cell Mechanoresponse Under Ultrasound Stimulation For Bone Repair
Presenting Author: Hanna Anderson


9:00 AM – 9:15 AM | 274 – Ultra-high Speed Imaging Of Osteoblast-microbubble Interactions For Bone Repair
Presenting Author: Nicholas Evans


9:15 AM – 9:30 AM | 275 – Development Of A High-frequency Ultrasound System To Assess The Microstructural, Contractile, And Mechanical Properties Of Engineered Cardiac Tissues
Presenting Author: Joseph Sebastian

Organs-on-Chips and Microbioreactors in Tissue Engineering

Chairs: Zhong Alan Li & Mario Rothbauer
SYIS Co-Chair: Ezgi Bakirci
Location: Ballroom 6E
Session Topic: Organoids, Bioreactors & Organ-on-Chip
Description: The development of advanced technologies such as organs-on-chips (OoCs) and microbioreactors has led to exciting progress in tissue engineering in the past decade. Human tissues engineered with such advanced technologies have demonstrated a level of tissue architecture, multi-tissue communications, biomechanical microenvironment, and physiological relevance not achievable with conventional in vitro culture methods. This has greatly enhanced our capability to regenerate diseased tissues and model medical conditions. In this Symposium, the Invited Speaker and other presenters will highlight the latest developments in engineered human tissues using emerging enabling technologies and discuss the potential of such technologies in advancing regenerative medicine, disease modeling, drug discovery, and personalized medicine. As research into artificial tissues and organs is trending upward and has led to exciting outcomes in scientific research and industry, the Symposium is expected to result in an active exchange of ideas and inspire many in the field of tissue engineering and regenerative medicine.

Keynote Speaker:
8:00 AM – 8:30 AM | Tissue Organoids Models of Tissue Development and Disease and Applications for Drug Discovery
Shay Soker

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 276 – A Next Generation Glomerulus-on-a-chip Promotes In Situ Tissue Patterning And Morphogenesis
Presenting Author: Xingrui Mou

8:45 AM – 9:00 AM | 277 – Effects Of Combined Recombinant Protein Therapy And Mechanical Loading On 3D-Bioprinted Patient-Specific Biomimetic Bone Organoids For Healthy And Osteogenesis Imperfecta Donors
Presenting Author: Anke de Leeuw


9:00 AM – 9:15 AM | 278 – Increased Hydrostatic Pressure But Not Shear-stress Promotes Ve-cadherin Internalisation: A Blood Vessel-on-chip Microfluidic Model Of Microvascular Dysfunction
Presenting Author: Pranav Vasanthi Bathrinarayanan


9:15 AM – 9:30 AM | 279 – ORGANOID-BASED HUMAN STOMACH MICRO-PHYSIOLOGICAL SYSTEM TO RECAPITULATE THE DYNAMIC MUCOSAL DEFENSE MECHANISM
Presenting Author: Hye-Jin Jeong

Scaffold Functionalization with Biomimetic Factors for TERM Applications

Chairs: Xinlong Wang & Ying Chen
SYIS Co-Chair: Juraski Amanda
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: The extracellular matrix, an assembly of multiple types of factors and molecules that surround cells in vivo, plays an important role in regulating cell functions and tissue regeneration. Highly bioactive scaffolds have been designed and developed to mimic the functions of extracellular matrices. So far, hybridization of organic/polymer compounds and inorganic compounds, immobilization of cell growth factors and proteins, grafting of biofunctional polymers, and incorporation of functional nanoparticles and bioactive molecules have been performed. In particular, growth factors and biofunctional polymers have been tethered or grafted to scaffolds by a variety of physicochemical, genetic and biological approaches. In this symposium, these approaches and functionalized scaffolds will be highlighted and discussed for their applications in stem cell research and TERM applications.

Keynote Speaker:
8:00 AM – 8:30 AM | Human Pluripotent Stem Cell-derived Rpe Cell Transplantation With Injectable Hydrogel Scaffolds For Retinal Degeneration
Akon Higuchi, PhD

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 281 – Can Gelma And Biomimetic Cultures Support The Establishment Of Mineralized 3d Osteocyte Networks?
Presenting Author: Nathalie Bock

8:45 AM – 9:00 AM | 282 – Fabrication & Physicochemical Characterization Of Lactoprene-βTCP(60:40) Composite Scaffolds For Scaffold Guided Bone Regeneration (SGBR)
Presenting Author: Dietmar Hutmacher


9:00 AM – 9:15 AM | 283 – Novel Biomimetic Surface Treatment For Improved Regeneration Of Endovascular Implants
Presenting Author: Hugo Level


9:15 AM – 9:30 AM | 284 – Mitochondrial Transfer To Recipient Bmscs Promotes Angiogenesis During Bone Repair
Presenting Author: Wenjing Li

Advances in Decellularization and Recellularization of Complex Tissues

Chairs: Golnaz Karoubi & Ian Rogers
SYIS Co-Chair: Sivashankari P. Rajasekaran
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: Decellularization and recellularization techniques have emerged as powerful tools in tissue engineering, enabling the creation of complex functional tissues for transplantation and regenerative medicine applications. This session aims to explore the latest advancements and breakthroughs in decellularization and recellularization strategies, focusing on their application in the development of complex tissue constructs.

Keynote Speaker:
8:00 AM – 8:30 AM | Bioengineered Grafts: the Future of Reconstructive Surgery
Siba Haykal

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 285 – Moderate Mechanical Ventilation Results In Enhanced Re-epithelialization Of Decellularized Lung Scaffolds
Presenting Author: Golnaz Karoubi

8:45 AM – 9:00 AM | 286 – Biomimetic Fibrous Scaffolds As Artificial ECM: A Novel Matrix To Animal-free Tissue Equivalents
Presenting Author: Tobias Weigel

9:00 AM – 9:15 AM | 287 – Bio-fabrication Of A Human IPSC-based Vascularized Endocrine Pancreas For The Treatment Of Type 1 Diabetes
Presenting Author: Francesco Campo

9:15 AM – 9:30 AM | 288 – Establishment Of A Human 3d Kidney Tissue Model Using Decellularized Rat Kidney Slices
Presenting Author: Haitham Salti

Advances in Skin Tissue Engineering – Session II

Chairs: Erbil Abaci & Helena Zomer
SYIS Co-Chair: Obisesan Temitope
Location: Room 611/612
Session Topic: Skin Regeneration, Wound Healing, and Inflammation
Description: This session will cover novel bioengineered and 3D-bioprinted grafts and models in skin tissue engineering.

Oral Abstract Presentations:
8:00 AM – 8:15 AM | 289 – Compassionate Use Of Allogeneic Self-assembled Skin Substitutes For Recessive Dystrophic Epidermolysis Bullosa Wound Closure
Presenting Author: Martin Barbier

8:15 AM – 8:30 AM | 290 – De Novo Formation Of Sebaceous Glands In Self-assembled Skin Substitute: Impact Of Human Epithelial Stem Cells
Presenting Author: Bettina Cattier

8:30 AM – 8:45 AM | 291 – Promoting Diabetic Wounds Repair Using Stem Cells And Drug-loaded Placenta-derived ECM Patches
Presenting Author: Hye Jin Kim

8:45 AM – 9:00 AM | 292 – Development Of A Functional Vascularized Skin Graft Using Gelatin Methacryloyl As Bioink
Presenting Author: Ho Ying Wan


9:00 AM – 9:15 AM | 293 – Pre-organized Cellular Components In Bioprinted Skin Improving Long Term Functionality Of Full Thickness Wounds
Presenting Author: Kelsey Willson


9:15 AM – 9:30 AM | 294 – 3d-printed Bilayer Scaffold/membranes For Tailored Differentiated Full-thickness Skin Models
Presenting Author: Maite Rielland

Discoveries in Regenerative Biology to Advance Regenerative Medicine

Chairs: Regina Brunauer & Dominik Hanetseder
SYIS Co-Chair: Genevieve Anghileri
Location: Room 606/607
Session Topic: Stem Cell Therapies, Developmental Biology and Cell Signaling
Description: Generally, tissue engineering and regenerative medicine seek the replacement of cells, tissues or organs. However, the phenomenon of epimorphic regeneration, which achieves complete structural appendage regeneration, inspires the vision to induce complex regeneration in human tissues in the future. Salamanders and fish are well known for their ability to fully regenerate appendages lost to amputation injuries, and mammalian paradigms of epimorphic regeneration, most prominently the regenerating mouse digit tip, are subject of intense study with the goal to eventually induce structural, multi-tissue regeneration in humans, or at least improve integration of implanted cells or scaffolds. As the molecular mechanisms of wound healing, establishment of a signaling center, blastema formation and pattern formation are being uncovered in non-amniotic vertebrates and mammals, paths to translation into mammalian tissues are becoming attainable. This session focuses on ideas and approaches to activate endogenous regenerative ability in non-regenerative tissues.

Keynote Speaker:
8:00 AM – 8:30 AM | Induction of Blastema Formation is Essential for Stimulating Regeneration in Mammals
Ken Muneoka, PhD

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 295 – Fgf8 Induces Bone And Joint Regeneration At Digit Amputation Wounds In Mice
Presenting Author: Lindsay Dawson

8:45 AM – 9:00 AM | 296 – Induction Mechanism Of Axolotl Limb Regeneration
Presenting Author: Akira Satoh


9:00 AM – 9:15 AM | 297 – Cellular And Molecular Profiling Of Critical Bone Fractures In Axolotls
Presenting Author: Anastasia Polikarpova


9:15 AM – 9:30 AM | 298 – Fetal Tendon In Vivo And Ex Vivo Healing Models Based On The Chick Embryo
Presenting Author: Catherine Kuo

International Collaborations in TERM

Chairs: Shengmin Zhang & Antonios Mikos
Location: Room 602/603/604
Session Topic: Special Session
Description: This special session will introduce research and translational examples and achievements of tissue-engineering projects to realize regenerative medicine through international collaboration. We have invited leading competitive researchers from different countries/regions to share their latest progress in international collaboration and translational research of TERMIS.

Panelists:
8:00 AM – 8:15 PM | Elastic solutions for cardiovascular repair
Anthony Weiss

8:15 AM – 8:30 AM | Emerging Trends in Global Collaboration for TERM
Shengmin Zhang


8:30 AM – 8:45 AM | The Added Value of Student Exchanges in International Collaborations
Antonios Mikos


8:45 AM – 9:00 AM | Collaboration of University and Company for Research and Development of TERM Technology
Yasuhiko Tabata


9:10 AM – 9:20 AM | Development of an injectable cartilage gel to treat degenerative cartilage disorders
Byung Hyune Choi


9:20 AM – 9:30 AM | The Need of a TERM Collaborative Platform to Accelerate Innovations in Fighting Pathogens and Modulating Immune Systems for Patients with Infectious and Other Compromised Conditions.
Ika Dewi Ana

RAPID FIRE: Musculoskeletal

Chairs: Iris Gerner & Michael McClure
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description:

Rapid Fire Presentations:
8:00 AM – 8:05 AM | 299 – Xenograft Of Bio-3D Printed Scaffold-free Cartilage Constructs For Regeneration Of Articular Cartilage In Immunodeficient Pigs
Presenting Author: Toshihiro Nonaka

8:05 AM – 8:10 AM | 300 – An Ex Vivo Culture Model To Study Zonal Articular Cartilage Calcification
Presenting Author: Eric Farrell

8:10 AM – 8:15 AM | 301 – An Injectable Composite Hydrogel System For The Controlled Release Of Platelet Lysate For The Repair Of Cartilage Defects
Presenting Author: Arjan Atwal

8:15 AM – 8:20 AM | 302 – Cartilage Organoid Production And Fusion Using Human Articular Chondroprogenitor Cells
Presenting Author: Keita Ito

8:20 AM – 8:25 AM | 303 – Towards Scalable And GMP-compliant Cartilage Microtissue Production In Bioreactors
Presenting Author: Flurina Staubli

8:30 AM – 8:35 AM | 304 – A HUMAN-SCALED KNEE BIOMIMETIC BIOREACTOR FOR PATIENT-SPECIFIC OSTEOCHONDRAL TISSUE ENGINEERING
Presenting Author: Iván López-González

8:35 AM – 8:40 AM | 305 – In Vivo Validation Of A Continuous Gradient Porous Scaffold For Osteochondral Defect Repair In A Rabbit Model
Presenting Author: Riccardo Gottardi

8:40 AM – 8:45 AM | 306 – Bioengineering Multi-tissue Musculoskeletal Interfaces For Enhanced Tissue Regeneration
Presenting Author: Vivian Lee

8:45 AM – 8:50 AM | 307 – Evaluating The Pre-vascularization Of Biomimetic Collagen Matrices For Enhanced Humanized Bone Tissue Engineering
Presenting Author: Sugandha Bhatia

8:50 AM – 8:55 AM | 308 – Mechano-immunomodulation Of Macrophages To Establish A Regenerative Environment For Bone Repair
Presenting Author: Stéphane Petrousek

9:00 AM – 9:05 AM | 309 – Development Of Sirna And Mrna Dual-loaded Lipidic Nanoparticles: Dual-targeting Fibrosis And Regeneration In Tendon Injury
Presenting Author: Giuseppina Molinaro

9:05 AM – 9:10 AM | Combination Therapy Improves Muscle Functional Recovery Following Volumetric Muscle Loss Injuries In The Gastrocnemius
Presenting Author: Olivia Sergent

9:10 AM – 9:15 AM | 311 – FAK Inhibition In Ligament Fibroblasts Decreases Collagen Fibril Formation, But Has No Effect On Fiber Or Fascicle Formation
Presenting Author: Tristan Strayer

9:15 AM – 9:20 AM | 312 – Antihypertrophic Activity Of Heparin During Mesenchymal Stromal Cell Chondrogenesis In Vitro
Presenting Author: Sven Schmidt

9:20 AM – 9:25 AM | 313 – Deciphering The WNT Contribution To Hypertrophic Chondrocyte Degeneration
Presenting Author: Solvig Diederichs

9:00 AM – 7:45 PM | Exhibit Hall Open

Location: Hall 4A

9:30 AM – 10:00 AM | Networking Coffee Break in Exhibit Hall

Location: Hall 4A
Meet with exhibitors to learn about their services and products.

9:40 AM – 9:55 AM | Combining Bioprinting, Microfabrication and Biomaterials to Create Advanced 3D Models

Sponsored by: Cellink
Speaker:
Location: Hall 4A

10:00 AM – 12:00 PM | Plenary Session 2 & TERMIS-AP Awards Presentation

Location: Ballroom 6 B/C

10:00 AM – 10:30 AM | Inclusive Research Strategies in Tissue Engineering and Regenerative Medicine
Alyson J. McGregor, MD, MA, FACEP

10:30 AM – 11:30 AM | Panel Discussion: Inclusive Research Strategies in TERM
Moderator: Brian Aguado
Panelists:
Simone Andrea Douglas-Green
Ana Maria Porras
Ariella Shikanov
Jennifer Elisseeff

11:30 AM – 12:00 PM | Asia Pacific Chapter Awards

12:00 PM – 1:30 PM | Lunch on Your Own

Enjoy lunch at one of the many restaurants located in and around the convention center.

12:00 PM – 1:30 PM | Women in TERM Luncheon: Creating Collective Impact (ticketed event)

Location: Ballroom 6E
Chair: Catherine K. Kuo (TERMIS-AM President-Elect)
Speakers: Barbara Chan (FTERM Class 2023)
Manuela Gomes (TERMIS-EU President-Elect, FTERM Class 2021)
Cherie Stabler (TERMIS-AM President)


All are welcome to attend this highly regarded and popular event at the conference, the women’s luncheon serves to create a supportive network of women in TERM. We would particularly encourage attendees in leadership positions to learn and listen about these challenges and help us brainstorm concrete ways to ensure we engage and retain women in this discipline. Tickets may be purchased during registration.

1:30 PM – 3:00 PM | Scientific Concurrent Session 7
Tissue Engineering and Biomanufacturing Advancements in Space

Chairs: Siobhan Malany, Sang Jin Lee & James Yoo
SYIS Co-Chair: Miri Amir K.
Location: Room 608/609
Session Topic: Biofabrication
Description: This session on biomanufacturing in space has the potential to make significant scientific contributions to biotechnology, space exploration, and medical research. By exploring the unique challenges and opportunities associated with biomanufacturing in a space environment, researchers and scientists could uncover new insights and develop innovative solutions that may lead to breakthroughs in medical applications and space technology.The session will bring together experts from various fields to discuss the latest advancements in biomanufacturing technology and explore the potential of these technologies in space. The discussions will focus on stem cell engineering, tissue engineering and regenerative medicine, 3D bioprinting, and space-based manufacturing of pharmaceuticals and other biologics. The symposium will provide a platform for researchers to share their findings and collaborate on new ideas and approaches to advance the field of biomanufacturing in space.Overall, the session has the potential to drive advances in biomanufacturing, leading to the development of new therapies, medical products, and space technologies that could significantly impact society.

Keynote Speaker:
1:30 PM – 2:00 PM | Understanding Degenerative Decline During Aging Using the Unique Environment of Space
Elizabeth Blaber PhD

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 314 – Biomanufacturing In Low Earth Orbit: Accelerating Breakthroughs In Regenerative Medicine
Presenting Author: Pinar Mesci

2:15 PM – 2:30 PM | 315 – Low Earth Orbit Testing Of Biomanufactured Vascularized Liver Tissue Constructs
Presenting Author: Kelsey Willson

2:30 PM – 2:45 PM | 316 – Production Of Extracellular Vesicles During Spaceflight In Skeletal Muscle Microphysiological Systems For Human Muscle Aging Research
Presenting Author: Maddalena Parafati

2:45 PM – 3:00 PM | 317- Investigating The Effects Of Microgravity On Ipsc-derived Neural Organoids Via Studies Conducted On The International Space Station
Presenting Author: Nicolette Pirjanian

Biomaterials for Controlled Delivery of Therapeutics

Chairs: Erika Wang & Ruoxiao Xie
SYIS Co-Chair: Sahimy Y. Ayus Martinez
Location: Room 615/616/617
Session Topic: Controlled Delivery of Therapeutics for Tissue Engineering
Description: This session brings together experts and trainees in the field of biomaterials, tissue engineering, and pharmaceutical science to delve into the latest innovations in advanced strategies for the controlled delivery of therapeutics. With a comprehensive scope, the session will encompass a diverse range of therapeutic modalities, including nucleic acid-based therapeutics, cell-based therapies, small molecules, and more. The primary objective of this session is to showcase recent breakthroughs in the development of micro- and nano-scale carriers that enable controlled and targeted drug delivery. The session will be structured to highlight various types of delivery systems, including: (1)Nanoscale Delivery Systems: Emphasizing lipid nanoparticles and their efficacy in therapeutic delivery. (2) Microscale Carriers: Spotlighting next-generation 3D printed micro- particles and devices designed for encapsulating therapeutic molecules. (3) Emerging Technologies: Showcasing other innovative approaches like hydrogels, ingestible devices, and injection-free systems. Attendees will gain insights into the development of biomaterials, engineered devices, and delivery systems designed to enhance therapeutic outcomes and pave the way for personalized medicine in tissue engineering and regenerative medicine.

Oral Abstract Presentations:
1:30 PM – 1:45 PM | 318 – Timed (temporal-integratedmicro-particleencapsulateddrugdelivery) Patch: A Hybrid Polymeric System For Programmed Drug Release To The Heart
Presenting Author: Erika Wang

1:45 PM – 2:00 PM | 319 – DHA Laden Liposome Anchored HA-menthol Hydrogel As Delivery System For Osteoarthritis Treatment
Presenting Author: Lu Feng


2:00 PM – 2:15 PM | 320 – A Bimetallic-organic-framework Loaded With Annexin A5 For The Treatment Of Inflammatory Bone Resorption
Presenting Author: Zhuoxuan Jia

2:15 PM – 2:30 PM | 321 – Re-thinking Drug Delivery With Mucosomes, Glycosylated Nanoparticles Bioinspired By Native Bioactive Mucins
Presenting Author: Lorenzo Sardelli

2:30 PM – 2:45 PM | 322 – Regional Delivery Of Sdf-1α Loaded Hydrogel Fragments To Supraspinatus Muscle After Rotator Cuff Injury
Presenting Author: Leah Anderson

2:45 PM – 3:00 PM | 323 – Injectable Antimicrobial Hydrogel For Extremity Wound Management In Low Resource Settings
Presenting Author: Gabrielle Lorenz

Skeletal Muscle Bioengineering and Volumetric Muscle Loss (VML) Repair

Chairs: Lisa Larkin & Michael McClure
SYIS Co-Chair: Eileen Su
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description: Volumetric muscle loss (VML) is the loss of muscle tissue which exceeds the body’s capacity for self-repair, resulting in impaired muscle function, and in many cases, physical deformity. While many musculoskeletal traumas may be endogenously repaired over time through the myogenic potential of satellite cells, more severe cases of VML overwhelm this native repair mechanism, creating a need for intervention. To date, the treatments for VML including the muscle flap or graft are not effective and are hindered by limited tissue availability and donor site morbidity. Thus, there is a critical need for new technologies to address VML. There are several labs that are diligently working on scaffold and cell-based technologies for engineering skeletal muscle to address the unmet need for a novel intervention to repair VML. This symposium will inform the participants about promising tissue engineering strategies currently being deployed both in vitro and in vivo that, in aggregate, have tremendous potential to identify improved strategies for the repair of volumetric muscle loss.

Keynote Speaker:
1:30 PM – 2:00 PM | Multidisciplinary Studies of Functional Muscle Repair and Replacement: Challenges and Opportunities for Clinical Translation
George Christ, PhD

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 324 – Engineering Biomimetic 3D Skeletal Muscle Architectures Using FRESH 3D Printed Collagen Scaffolds
Presenting Author: Maria Stang

2:15 PM – 2:30 PM | 325 – Evaluation Of MuscleMatrix™ For Repair Of Volumetric Muscle Loss (VML) Injuries In The Rat Gastrocnemius
Presenting Author: Sydney Shriver

2:30 PM – 2:45 PM | 326 – Repair Of Volumetric Muscle Loss Injury Using Growth Factor Encoding MMRNA On A Bioengineered Aligned Scaffold In Two Animal Models
Presenting Author: Sarah Greising

2:45 PM – 3:00 PM | 327 – Repairing Volumetric Muscle Loss With Commercially Available Hydrogels In The Ovine Peroneus Tertius Muscle
Presenting Author: Eileen Su

Combining Different Approaches for Translational Nerve Tissue Engineering and Regeneration

Chairs: Melissa Rayner & Alexane Thibodeau
SYIS Co-Chair: Mona Zolfaghar
Location: Room 618/619/620
Session Topic: Neural & Spine
Description: Damage to nerves can cause debilitating consequences to patients such as lifelong pain and disability. At present, treatment options are limited and even in the best-case scenario, recovery is still incomplete and unsatisfactory. Worldwide, research groups are using multidisciplinary approaches to develop therapies to repair nerves. The aim of this session is to bring these researchers, clinicians, and industry partners together to disseminate the current advancements in the field, build networks and ignite discussions and international collaborations. Within this session the research presented will span a broad range of disciplines ranging from biomaterials, model development, drug therapeutics and cell and gene-based therapies; all-encompassing the tissue engineering and regenerative medicine focus of the TERMIS meeting. We would also like to use this session to highlight the clinically translatable research that is being conducted across labs and what the future holds for this field.

Keynote Speaker:
1:30 PM – 2:00 PM | Nerve tissue engineering and acceleration of regeneration
James Phillips, Professor

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 328 -Inflation Of Single-lumen Human Brain Organoids Enhances Tissue Organization And Stemness
Presenting Author: Ezekiel Benshirim

2:15 PM – 2:30 PM | 329 – Combinatorial Hipsc-Neuron And Engineered Biomaterial Transplantation Therapy ToTreat Chronic Spinal Cord Injury
Presenting Author: Vanessa Doulames

2:30 PM – 2:45 PM | 330 – 3d Bio-printed Photo-clickable Scaffolds Combined With Transplantation Of Human Spinal Cord Progenitor Cells Promote Nerve Regeneration After Spinal Cord Injury
Presenting Author: Vaibavi Ramanujam

2:45 PM – 3:00 PM | 331 – Injectable Peptide Hydrogels For SVF Cells Delivery In Conduits For Peripheral Nerve Regeneration
Presenting Author: Alberto Saiani

Functionalized Biomaterials for Tissue Engineering Applications

Chairs: Alison McGuigan & Golnaz Karoubi
SYIS Co-Chair: Fan Zhang
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: The use of biomaterials as therapeutics has emerged as a revolutionary approach within the field of tissue engineering, aiming to highlight their significant role in advancing regenerative medicine and accelerating clinical applications. In this session, we explore the design, fabrication, and functionalization of biomaterials, with a focus on enhancing their therapeutic potential and promoting tissue regeneration.

Keynote Speaker:
1:30 PM – 2:00 PM | Design and Translation of Injectable ECM Biomaterials
Karen Christman, PhD

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 332 – Elastic And Hemostatic Human Protein-based Surgical Sealant For The Rapid Closure Of Ruptured Soft Tissues
Presenting Author: Saumya Jain

2:15 PM – 2:30 PM | 333 –
Presenting Author:

2:30 PM – 2:45 PM | 334 – Mechanically Stimulated Piezoelectric Scaffolds Enhance In Vitro Osteogenic Differentiation And In Vivo ECM Formation
Presenting Author: Maria Chatzinikolaidou

2:45 PM – 3:00 PM | 335 – Enhanced Physiochemical, Antibacterial, And Hemostatic Performance Of Collagen-quaternized Chitosan-graphene Oxide Sponges For Promoting Infectious Wound Healing
Presenting Author: Chuchao Zhou

Injectable Scaffolds

Chairs: Wenxin Wang & Rijian Song
SYIS Co-Chair: Nancy Avila Martinez
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: The development of injectable hydrogel scaffolds has been a focus of research in tissue engineering and regenerative medicine. These scaffolds offer unique advantages such as ease of application, site-specific action, and improved patient compliance. Injectable scaffolds also provide a uniform distribution of cells within the scaffold, creating an environment that promotes tissue regeneration. Despite significant advancements, there are still challenges in the design and development of injectable scaffold-cell systems. These include optimizing the solidification process, maintaining a conducive environment for tissue growth under mechanical stress, controlling drug/growth factor release, ensuring biocompatibility and cell viability during scaffold preparation and delivery, and understanding cell-material interaction. To address these challenges, a symposium focused on injectable scaffolds would be an ideal fit for the conference, connecting researchers from synthetic chemists to applied scientists, engineers, and clinicians. Injectable hydrogel scaffolds, formed by in situ crosslinking of aqueous gel mixture precursors, have emerged as promising biomaterials for tissue engineering applications. The symposium will cover recent advances in the development of injectable hydrogels for biomedical applications, highlighting their advantages over conventional pre-fabricated hydrogels, such as reduced cell damage, immune protection, easy manipulation, and minimal invasive procedures.

Keynote Speaker:
1:30 PM – 2:00 PM | Biomaterials for the Generation of Scaffolds Through the Power of Light
Jasper Van Hoorick, PhD

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 336 – Designing Injectable Peptide Hydrogels For Cell Delivery
Presenting Author: Alberto Saiani

2:15 PM – 2:30 PM | 337 – Cell-delivering Porous Injectable Hydrogels Engineered By Liquid-liquid Phase Separation For The Treatment Of Hindlimb Ischemia
Presenting Author: Akihiro Nishiguchi

2:30 PM – 2:45 PM | 338 – Reshaping Hydrogel Scaffolds: Microporous Annealed Crescent (MAC) Particles For Enhanced Tissue Integration And Cell Delivery
Presenting Author: Richie Tang

2:45 PM – 3:00 PM | 339 – Injectable Shape Memory Cryogel Microspheres For Stem Cells Delivery And Functionalized Tissue Engineering
Presenting Author: Xiaojing Yuan

Extracellular Vesicles in TERM

Chairs: Manuel Gomez-Florit & Hector Capella-Monsonis
SYIS Co-Chair: Chloé Dujardin
Location: Room 606/607
Session Topic: Stem Cell Therapies, Developmental Biology and Cell Signaling
Description: In recent years, research on cell secretome and extracellular vesicles (EVs) for diagnostic and therapeutic applications have generated great interest in the Tissue Engineering and Regenerative Medicine research community. The secretome and EVs hold an immense potential to provide novel strategies to treat a variety of diseases and to revolutionize healthcare, since they are crucial at regulating molecular key processes in health and disease. This symposium aims to provide a comprehensive overview of the current research on the applications of the secretome and EVs in tissue engineering and regenerative medicine, and their impact on personalized strategies. We welcome presentations from, but not limited to, the following topics: i) the biology, biochemistry and biosynthesis of the secretome and EVs; ii) the use of secretome and EVs in diagnostics and therapeutics; iii) the applications of EVs in bioengineering strategies, including biomaterial-secretome based approaches iv) Secretome as a source of biomarkers in personalized and regenerative medicine Target Audience: We expect that the symposium will be of interest to most of conference attendees, including basic scientists, clinicians and industry/companies. We would like to offer the whole life cycle of the use of secretome and EVs in regenerative medicine, i.e., from the bench to the bedside. Additionally, our objective is to gather researchers working on this topic to generate a critical mass and gain momentum within the tissue engineering and regenerative medicine community.

Keynote Speaker:
1:30 PM – 2:00 PM | High-resolution analysis of single extracellular vesicles and particles with digital flow cytometry and super-resolution imaging
Professor Daniel T. Chiu

Oral Abstract Presentations:
2:00 PM – 2:15 PM | 340 – Three-dimensionally Cultured Human Adipose Derived Stem Cell Exosomes For Diabetic Wound Healing
Presenting Author: Edgar Quiñones

2:15 PM – 2:30 PM | 341 – Not All Extracellular Vesicles Are Made Equal: Comparison Of Matrix Binding And Media Vesicles For Hard Tissue Regeneration
Presenting Author: Genevieve Anghileri

2:30 PM – 2:45 PM | 342 – Intravenous Delivery Of Mesenchymal Stem Cells-derived Extracellular Vesicles (msc-evs) As A Potential Treatment For Tendon And Cartilage Degeneration In Type Ii Diabetes (t2d)
Presenting Author: Sik Loo Tan

2:45 PM – 3:00 PM | 343 -Development Of Osteoclast-derived Exosomes For Cardiovascular Calcification Therapy
Presenting Author: Isabella Jennings

RAPID FIRE: In Vitro Models in TERM

Chairs: Lorenzo Moroni & Richard McFarland
Location: Room 611/612

Rapid Fire Presentations:
1:30 PM – 1:35 PM | 344 – Evaluation Of Anticancer Efficacy And Osteostimulative Potency Of Bifunctional Nanobiomaterials In Bone Metastatic Spheroids
Presenting Author: Ceri-Anne Suurmond

1:35 PM – 1:40 PM | 345 – Modeling Tumor Stromal Matrix Structure And Its Impact On T Cell Immunotherapy
Presenting Author: Ruogang Zhao

1:40 PM – 1:45 PM | 346 – Engineering Microscale Co-cultures Of Ipsc-derived Cardiomyocytes And Fibroblasts Via Photopatterned Alginate
Presenting Author: Emanuele Spanghero

1:45 PM – 1:50 PM | 347 – Malaria-induced Dysregulation Of The Angiopoietin-tie Pathway And Pericytes In A 3d Cerebral Microvascular Model
Presenting Author: Rory Long

1:50 PM – 1:55 PM | 348 – Composite Natural-based Hydrogels Engineered To Model Tissue-specific Microenvironments
Presenting Author: Annalisa Tirella

2:00 PM – 2:05 PM | 349 – Development And Validation Of An Electrical Bioreactor To Generate Cardiac Tissue
Presenting Author: Nohra Beltran Vargas

2:05 PM – 2:10 PM | 350 – Multiwell Platform To Elucidate Reciprocal Interactions Between Human Cardiomyocytes And Hepatocytes
Presenting Author: Emanuele Spanghero

2:10 PM – 2:15 PM | 351 – New 3d Platform For Sinonasal Tumors Study
Presenting Author: Serena Danti

2:15 PM – 2:20 PM | 352 – Fabrication Of Hierarchical And Bio-mimetic Vascular System For Volumetric 3D Tissue Model
Presenting Author: Jeonghyun Son

2:20 PM – 2:25 PM | 353 – Establishment Of Ipsc-derived Neuronal Model From Patient With Mitochondrial Defects
Presenting Author: Fazlina Nordin

2:30 PM – 2:35 PM | 354 – Optimization Of An Ex Vivo Perfusion Machine For Tumor-bearing Organs
Presenting Author: Hannah Stepp

2:35 PM – 2:40 PM | 355 –
Presenting Author:

2:40 PM – 2:45 PM | 356 – Development And Characterization Of A Defined Inflamed Adipose Tissue Model For Obesity Research
Presenting Author: Sophia Nowakowski

2:50 PM – 2:55 PM | 358 – 3D Brain Microvascular Model For Malaria Infection And The Effect Of Fever
Presenting Author: Viola Introini

Celebrating 30 Years of Tissue Engineering: A Journey through Science, Innovation, and Impact

Chairs: Antonios Mikos & John Fisher
Location: Room 602/603/604
Session Topic: Special Session
Description: Join us at the TERMIS World Congress for an exclusive in-person workshop hosted by world-renowned experts in the field as we commemorate the 30th Anniversary of Tissue Engineering. This exclusive event will recognize the pivotal role played by the Founding Editors of the journal along with TERMIS and the global TERMIS community, and will cover the remarkable evolution of the field over the past three decades.The workshop will highlight meaningful historical perspectives along with emerging global trends, tools & technologies, and the future of R&D growth and innovation within the field of tissue engineering and regenerative medicine. Please join us in celebration of the field and Tissue Engineering and enjoy the exclusive talks, presentations, networking opportunities, and personal stories that shaped the course of the field. All are welcome.

1:30 PM – 1:55 PM | Overview of 30 Years – Drs. John Fisher and Antonios Mikos
1:55 PM – 2:10 PM | Presentation by Dr. Wagner on Scaffolding
2:10 PM – 2:25 PM | Presentation by Dr. Gomes on 3D Printing
2:25 PM – 2:40 PM | Presentation by Dr. El Haj on Engineering Tissues in vitro
2:40 PM -3:00 PM | Panel Discussion Moderated by Drs. John Fisher and Antonios Mikos

3:00 PM – 3:15 PM | Transitional Break

3:15 PM – 4:45 PM | Scientific Concurrent Session 8
Biomaterials for Controlled Delivery of Therapeutics – Session II

Chairs: Tram Dang
SYIS Co-Chair: Nam Tran
Location: Room 615/616/617
Session Topic: Controlled Delivery of Therapeutics for Tissue Engineering
Description:

Oral Abstract Presentations:
3:15 PM – 3:30 PM | 359 – Development Of Hydrogels For Sequential, Affinity-Controlled Delivery Of Angiogenic Growth Factorsv
Presenting Author: Justin Svendsen

3:30 PM – 3:45 PM | 360 – Degradable Microneedle Patch Loaded With Doxycycline Hydrochloride And Vascular Endothelial Growth Factors For Promoting Diabetic Wound Healing
Presenting Author: Yufang Tan


3:45 PM – 4:00 PM | 361 – Beyond Batch Variability: Microfluidic Solutions For Controlled Therapeutic Nano-delivery
Presenting Author: Sara Gimondi

4:00 PM – 4:15 PM | 362 – Effects Of Heparin Hydrogel Sulfation Level On TSG-6 Release And Tissue Response After Supraspinatus Muscle Injury
Presenting Author: Joseph Pearson

4:15 PM – 4:30 PM | 363 – Gene Therapy Of Recessive Dystrophic Epidermolysis Bullosa Skin Cells Leads To Dermo-epidermal Adhesion Strength Restoration In Autologous Bilayered Self-assembled Skin Substitutes
Presenting Author: Martin Barbier

4:30 PM – 4:45 PM | 364 – Hydrogel Platform For Localized Sustained Delivery Of Clinically Relevant Costimulation Blocking Biologics For Immunomodulation In Allogeneic Cell Transplantation
Presenting Author: Oriana Marrone Mantovani

Non-Invasive Imaging Applications for Regenerative Medicine and Tissue Engineering

Chairs: Marcella Vaicik & Ryuji Kato
SYIS Co-Chair: Viola Introini
Location: Room 611/612
Session Topic: Imaging and Assessment
Description: This session will highlight research that utilizes the assessment of tissue-engineered constructs’ structure and function through non-invasive imaging techniques. The session aims to explore the applications of advanced imaging modalities such as electron paramagnetic resonance oxygen imaging (EPROI), magnetic resonance imaging (MRI), MR elastography (MRE), computed tomography (CT), single photon emission CT (SPECT), molecular and functional optical imaging techniques, and ultrasound, etc. in evaluating the structure and functional properties of cells and tissue constructs. By highlighting research with non-invasive imaging techniques, this session aims to advance the field of tissue engineering and regenerative medicine by providing valuable insights into characterization, optimization, and tissue growth.

Keynote Speaker:
3:15 PM – 3:45 PM | Vascular regulation of tissue regeneration and ageing
Anjali Kusumbe, PhD

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 365 – High-resolution Mapping Of Oxygen Tension In Tissue-engineered Constructs With Ruthenium-complex Nanomicelle Optical Sensors
Presenting Author: Kevin Schilling

4:00 PM – 4:15 PM | 366 – Noninvasive, Real-time Multimodality Imaging Reveals How Oxygen Releasing Scaffolds Enhance Bone Fracture Healing In Vivo
Presenting Author: Yunke Ren

4:15 PM – 4:30 PM | 367 – Design And Development Of An Aptamer-Based Biosensor For Monitoring Cell Seeding In Tissue Engineering Applications
Presenting Author: Rodrigo Somoza

4:30 PM – 4:45 PM | 368 – Automated Quantification Of 3d Spheroid Invasion In Hydrogel Scaffolds Using Grid-based Image Segmentation
Presenting Author: Rayan Abdulhadi

Skeletal Muscle Bioengineering and Volumetric Muscle Loss (VML) Repair – Session II

Chairs: Sarah Greising & Karina Nakayama
SYIS Co-Chair: Justin Matta
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description: This abstract-driven session will focus on volumetric muscle loss injury and repair. Volumetric muscle loss is the loss of muscle tissue which exceeds the body’s capacity for self-repair, resulting in impaired muscle function, and in many cases, physical deformity. While many musculoskeletal traumas may be endogenously repaired over time through the myogenic potential of satellite cells, more severe cases of VML overwhelm this native repair mechanism, creating a need for intervention. There is currently a critical need for new technologies to address VML. This symposium will inform the participants about promising tissue engineering strategies for the repair of volumetric muscle loss.

Oral Abstract Presentations:
3:15 PM – 3:30 PM | 369 – Stretchable Alginate/GelMA Interpenetrating Network (IPN) Hydrogel Microsprings Based On Coaxial Microfluidic Technique For Skeletal Muscle Tissue Engineering
Presenting Author: TIng Li

3:30 PM – 3:45 PM | 370 – Automated Microfluidic-assisted Wet-spinning For The Biofabrication Of Engineered Myotendinous Junction
Presenting Author: Marina Volpi

3:45 PM – 4:00 PM | 371 – An Innovative Approach To Generating Implantable Tissue-engineered Muscle For The Treatment Of Volumetric Muscle Loss
Presenting Author: Lívia Santos

4:00 PM – 4:15 PM | 372 – Brown Adipogenic Differentiation Of Fibro-adipogenic Progenitors Is Associated With Increased Miro1 Gene Expression And The Formation Of Mitochondria-rich Tunneling Nanotubes
Presenting Author: Christian Mendiondo

4:15 PM – 4:30 PM | 373 – Biosponge-encased Placental Stem Cells Enhance Regeneration And Diminish Fibrosis Following Volumetric Muscle Loss
Presenting Author: David Johnson

4:30 PM – 4:45 PM | 374 – Pulsed-electromagnetic Field Stimulation And Mechanical Stimulation For Enhancing Bovine Myoblast Myogenesis
Presenting Author: Chloë Deelkens

Human Myocardium Models to Recapitulate Heart Physiology and Pathology

Chairs: Elisabeth Engel, Carmine Gentile & Lorenzo Moroni
SYIS Co-Chair: Tia Calabrese
Location: Room 606/607
Session Topic: Organoids, Bioreactors & Organ-on-Chip
Description: The symposium aims to bring together leading researchers, scientists, and clinicians in the field of regenerative medicine and cardiac biology. The symposium will provide a platform for in-depth discussions and knowledge exchange on the latest advancements in developing human myocardium models that accurately recapitulate the complex physiology and pathology of the heart. The human heart is a remarkable organ with intricate structure and function. Understanding its physiology and pathology is crucial for advancing treatments for cardiovascular diseases. The symposium aims to share insights into the design, fabrication, and characterization of human myocardium models. These models aim to capture the functional and structural properties of native heart tissue while incorporating disease-specific features. Various approaches, including 3D bioprinting, organoids, and microphysiological systems, will be explored, highlighting their potential to recapitulate heart physiology and pathology in vitro. Moreover, discussions will focus on the integration of advanced imaging techniques, genetic engineering tools, and computational modeling to enhance the fidelity and predictive power of these models. The symposium will provide a platform for participants to exchange ideas, establish new partnerships, and shape the future directions of research aimed at recapitulating heart physiology and pathology using human myocardium models.

Keynote Speaker:
3:15 PM – 3:45 PM | Bioengineering the Human Heart Pathophysiology using Personalised Bioinks
Carmine Gentile, PharmD/PhD, FAHA

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 375 – Mantarray 3D Engineered Muscle Tissue Platform Demonstrates Clinically-Relevant Disease Stratification Of An In Vitro Human Duchenne Muscular Dystrophy Model
Presenting Author: Shawn Luttrell

4:00 PM – 4:15 PM | 376 – Dissecting Cardiomyocyte-fibroblast Communication During Homeostasis And Cardiac Fibrosis In A Compartmentalized Biomimetic Tissue Model
Presenting Author: Samuel DePalma

4:15 PM – 4:30 PM | 377 – Advanced In Vitro Cardiac Modeling: A Novel IPSC-based Cardiac Organoid
Presenting Author: Rosaria Santoro

4:30 PM – 4:45 PM | 378 – ER Stress And Lipid Imbalance Drive Embryonic Cardiomyopathy In A Human Heart Organoid Model Of Pregestational Diabetes
Presenting Author: Aleksandra Kostina

Innovative Cell Instructive Biomaterials for Regenerative Medicine

Chairs: António Salgado & Kee Woei Ng
SYIS Co-Chair: Nima Tabatabaei Rezaei
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: Understanding the interaction between cells and extracellular environment is a fundamental prerequisite in order to engineer functional biomaterial interfaces able to instruct cells with specific commands. Engineered cell instructive microenvironments with the ability to stimulate specific cellular responses are a topic of high interest in the fabrication and development of biomaterials for application in tissue engineering. Cells are inherently sensitive to the in vivo microenvironment that is often designed as the cell “niche.” The cell “niche” comprising the extracellular matrix and adjacent cells, influences not only cell architecture and mechanics, but also cell polarity and function. Indeed, Such advanced biomaterials might find relevant application in prosthesis design, tissue engineering, diagnostics and stem cell biology. As a consequence extensive research has been performed to establish new tools to fabricate biomimetic advanced materials for tissue engineering and regenerative medicine, that incorporate structural, mechanical, and biochemical signals that interact with cells in a controlled manner and to recapitulate the in vivo dynamic microenvironment. As a consequence of this bioactive tunable microenvironments using micro and nanofabrication have been successfully developed and proven to be extremely powerful to control intracellular signaling and cell function. The present symposium aims at discussing the most recent findings on material-induced cell responses, with a particular emphasis on their impact in tissue engineering and regenerative medicine of different tissues

Keynote Speaker:
3:15 PM – 3:45 PM | 379 – Instructing Collagen-based Biomaterials And Human Cells To Work Together For Remodeling The Structure Of Vessel Wall For Advanced In Vitro Models
Professor Diego Mantovani

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 380 – Tailoring Cell Attachment Via Unconventional Use Of Peptide-functionalized Phase-separated Coating Of 3d Printed Microfiber Scaffolds
Presenting Author: Kelly O’Neill

4:00 PM – 4:15 PM | 381 – The Boron Transporter NaBC1 Mediates Mechanotransduction Via Fibronectin-Binding Integrins
Presenting Author: Juan Gonzalez-Valdivieso

4:15 PM – 4:30 PM | 382 – Body Warmth Anchoring Of L-arginine/Ca2+/nitric Oxide Shape Memory Bone Screws Propagate Mechanical Stimulation, Energize Bone Cells And Augment Bone Regeneration
Presenting Author: Huaqian Liu

4:30 PM – 4:45 PM | 383 – Innovative Gradient-free Cancer Traps: Mechanically Guided Capture Of Metastatic Cells For Enhanced Therapeutic Efficacy
Presenting Author: David Caballero

Naturally Derived Biomaterials for Sustainable TERM

Chairs: Su Ryon Shin & Shabir Hassan
SYIS Co-Chair: Damian Hutchins
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: Researchers working using natural biomaterials for tissue engineering and regenerative medicine, drug screening and drug delivery will get an opportunity to learn about the current methodologies and techniques for developing sustainable, innovative scaffolds and biomimetic-based matrices for cell culture, including hydrogels. This will include novel 3D cell culture models that are aimed at improving the patient’s quality of life. Sustainable natural-based biomaterials will be investigated to further develop different 3D regeneration models for therapies and disease screening in microenvironment dynamics, including nanomaterial fabrications. These latest advances will provide a means to engineer the in vitro (and even in vivo) cellular microenvironment and cell migration to study and manipulate various hard and soft tissues. Advances made with 3D (bio) printing using hydrogel as bio-ink, micropatterning, and microfluidic devices for the study of tissue growth, stem cell differentiations for soft- and hard tissue engineering, including optical and bioelectronic properties are also within the scope of the session. Despite certain advances, developing matrices with good electrical and mechanical properties in physiological environments remains challenging. The presentations will discuss the emerging techniques to better understand cell-based tissue engineering and regenerative medicine methods in vitro and/or in vivo platforms. This symposium will explore the designing of sustainable natural biomaterials for different tissue regeneration processes.

Keynote Speaker:
3:15 PM – 3:45 PM | Human-derived biomaterials for tissue engineering
Joao Mano

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 384 – Improving Hemocompatibility Of Titania Nanotube Surfaces Using An Algae-derived Biopolymer Alternative To Heparin
Presenting Author: Somayeh Baghersad

4:00 PM – 4:15 PM | 385 – Preclinical Development Of Osteogrow-C – A Novel Device For Bone Regeneration
Presenting Author: Nikola Stokovic

4:15 PM – 4:30 PM | 386 – Eggshell-derived Amorphous Calcium Phosphate: Synthesis, Characterization And Bio-functions As Bone Graft Materials In Novel 3d Osteoblastic Spheroidic Model
Presenting Author: Qianli Ma

4:30 PM – 4:45 PM | 387 – Natural Compounds From The Seafood Waste To Ameliorate Skin Repair
Presenting Author: Luca Melotti

Stem Cell-based Therapies in Tissue Engineering

Chairs: Kapil Bharti & Budd Tucker
SYIS Co-Chair: Jinal Mehta
Location: Room 618/619/620
Session Topic: Stem Cell Therapies, Developmental Biology and Cell Signaling
Description: Pluripotent stem cells (PSCs) provide autologous and allogeneic replacement tissues for the treatment of potentially all degenerative diseases. Several groups are interested in developing autologous and allogeneic PSC based therapies for degenerative diseases. However, major challenges remain in translating these therapies into clinic. There are challenges to develop clinical grade PSC lines, how to quality control them and test the derived product for preclinical and clinical use. The main goal of this symposium is to discuss approaches various groups are taking to develop a regulatory compliant path to develop an PSC based cell therapy and highlight some of the major challenges that lie ahead of us.

Keynote Speaker:
3:15 PM – 3:45 PM | Regenerative Medicine for Retinal Diseases; Progress and Challenges
Thomas Reh

Oral Abstract Presentations:
3:45 PM – 4:00 PM | 388 – An Axis Of Wnt And Proinflammatory Signals Underlies Mechanically Driven Osteogenesis
Presenting Author: Hussain Jaffery

4:00 PM – 4:15 PM | 389 – Connexin Rich Biomaterials Synchronize Induced Pluripotent Stem Cell-derived Cardiomyocytes Beating
Presenting Author: Janet Zoldan

4:15 PM – 4:30 PM | 390 – Hydrogel Injection Molding Macroencapsulation Of Human Stem Cell-derived Beta Cells Ameliorates Rejection In Car T Cell Humanized Mice
Presenting Author: Jinal Mehta

4:30 PM – 4:45 PM | 391 – Tissue Chips For Advanced Multipotent Stromal Cell Manufacturing
Presenting Author: Ishita Jain

SYIS Career Panel

Chairs: Ram Rao & Marcelo Muñoz
Location: Ballroom 6E
Session Topic: Special Session
Description: SYIS Career Panel: Our annual Career Panel will include young professionals representing careers in different TERM sectors, including academia, industry, government, publishing, or biomedical start-ups. In addition to a moderated discussion, this panel will include a Q&A portion where attendees may ask panelists about their career paths and experiences.

Learning from Successful Failures in Tissue Engineering & Regenerative Medicine

Chairs: Sing Yian Chew & Catherine Le Visage
SYIS Co-Chair:
Location: Room 602/603/604
Session Topic: Special Session
Description: The advancement of science traditionally relies heavily on the positive results and outcomes from the scientific community. Indeed, the field of Tissue Engineering & Regenerative Medicine (TERM) has advanced greatly in the past 2 decades due to positive contributions and reports in the field. On the other hand, the lack of positive experimental outcomes, such as the absence of correlation of in vitro cellular responses with in vivo treatment efficacies, is often seen as failures and frequently remains unreported. This is a great loss to the field since failures have undeniably taught us a great deal and may in fact be more helpful than the typically defined successful experimentations. In this symposium, we have invited successful scientists to share the truth of science and how they have learnt from failures and lack of efficacy as observed in vivo and moved ahead. The symposium aims to gather scientists from different aspects of TERM to share their journey in learning from successful failures to inspire the current and next generation of scientists.

Panelists:
3:15 PM – 3:35 PM | Embracing failures
Barbara Chan

3:35 PM – 3:55 PM | The high value of bad data in 3D printing of tissue engineering scaffolds
Antonios Mikos

3:55 PM – 4:15 PM | Failing to Succeed
Molly Shoichet

4:15 PM – 4:45 PM | Panel Discussion

RAPID FIRE: 3D Tumor Models

Chairs: Alison McGuigan & Brendan Harley
SYIS Co-Chair: Juan Gonzalez-Valdivieso
Location: Room 608/609
Session Topic: Cancer
Description:

Rapid Fire Presentations:
3:15 PM – 3:20 PM | 407 – Engineered 3D “MatriSpheres” Recapitulate In Vivo Colorectal Tumor Stroma & Cancer Cell Phenotype
Presenting Author: Michael Buckenmeyer

3:20 PM – 3:25 PM | 408 – Establishment Of Patient-Derived 3D Tumouroids And Matched Xenografts: Personalised Medicine Tools For Renal Cancer
Presenting Author: Kalliopi Bokea

3:25 PM – 3:30 PM | 409 – 3D Printable Methacrylated Collagen Type I-based Hydrogels To Study Migration Of Breast Cancer Cells
Presenting Author: Sabrina Stecher

3:30 PM – 3:35 PM | 410 – 3d Bio-printed In Vitro Osteosarcoma Model-on A-chip For Anticancer Drug Screening Applications
Presenting Author: Bibrita Bhar

3:35 PM – 3:40 PM | 411 – A Developmental Tissue Engineering Approach To Study Breast Cancer Metastasis To The Bone
Presenting Author: Andrea Lolli

3:45 PM – 3:50 PM | 412 – Customized Hydrogel Systems For Cancer-stroma-endothelium 3D Co-culture And Therapuetics Screening In A Perfused Microfluidic Plate
Presenting Author: Daniel Harrington

3:50 PM – 3:55 PM | 413 – The Cross-talk Between Microglia And Glioblastoma Organoids And Its Effect On Chemotherapeutic Resistance
Presenting Author: Hemamylammal Salem Muthu Sugavanam Sivakumar

3:55 PM – 4:00 PM | 414 – Development Of Complex Melanoma Spheroids Through An Assembloid-based Approach
Presenting Author: Rogério P Pirraco

4:00 PM – 4:05 PM | 415 – A Human-derived 3d Model Of Prostate Cancer As A Precision Medicine Tool
Presenting Author: Félix-Antoine Pellerin

4:05 PM – 4:10 PM | 416 – A 3d, Compartmental Tumoroid Model Of Patient-derived Bone Metastasis
Presenting Author: Mansoureh Mohseni Garakani

4:15 PM – 4:20 PM | 417 – Visualizing Epithelial-to-mesenchymal Transition-induced Lung Cancer Intravasation In A Microphysiological System Of The Microvasculature
Presenting Author: Christy Wing Tung Wong

4:20 PM – 4:25 PM | 418 – Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity In Cancer
Presenting Author: Eliza Li Shan Fong

4:25 PM – 4:30 PM | 419 – A Tissue-engineered Approach To Model Pancreatic Cancer
Presenting Author: Verena Kast

4:30 PM – 4:35 PM | 420 – Bioengineering 3D Leukemic Niches To Develop Stem Cell Therapies
Presenting Author: Ioannis Angelos Tsigkos

4:35 PM – 4:40 PM | 421 – Modelling The Interface Between Lung Cancer And The Immune System For Early Detection Biomarkers
Presenting Author: Andrew Blake

4:15 PM – 5:15 PM | SYIS Mixer

Location: Room 307-308

Join us for a networking event following the Career Panel! Several academic and industry professionals will be in attendance to speak with students and young investigators about their career paths and experiences. Light food and drink will be served. A ticket must be purchased during the conference registration to attend.

4:45 PM – 5:15 PM | Networking Coffee Break in Exhibit Hall

Location: Hall 4A
Meet with exhibitors to learn about their services and products.

4:50 PM – 5:05 PM | BMAP® Knee: A Human-Scaled Knee Biomimetic Bioreactor for Patient-Specific Osteochondral Tissue Engineering

Sponsored by: Regemat3D
Location: Hall 4A

5:10 PM – 5:25 PM | Unlock Half a Million in Funding: Tips to Win the Burroughs Wellcome Fund’s Innovations in Regulatory Science Award

Sponsor: Burroughs Wellcome Fund
Speaker: Tammy Collins, Program Officer
Location: Hall 4A

Calling all researchers at TERMIS! Don’t miss this information session on the Burroughs Wellcome Fund’s Innovations in Regulatory Science Awards. Discover what it takes to secure up to $500K in research funding. Join us for a brief yet insightful overview where we’ll reveal exactly what BWF is looking for in award candidates. Elevate your research with insider tips and boost your chances of winning this prestigious grant!

5:15 PM – 6:15 PM | Jensen Tissue Engineering Award Presentation

Location: Ballroom B/C

Recipient: Gordana Vunjak-Novakovic, PhD

6:15 PM – 7:45 PM | Poster Session 3

Location: Hall 4A

Meet with exhibitors to learn about their services and products. Check out the great science in the poster presentations. Take time to meet with the authors and discuss their findings. Light appetizers and beverage will be served.

6:25 PM – 6:40 PM | Next-generation designer culture media for in vitro 2D/3D modeling
and serum-free media engineered for clinical scenarios

Sponsored by: CELLnTEC Advanced Cell Systems
Location: Hall 4A
Speakers:
Dr. Stefan Baertschi (Head of R&D)
Dr. Anand David, Scientific Marketing Manager

CELLnTEC is a pioneering developer of human and animal component-free precision media enabling scientists to successfully traverse the basic to translational research continuum and establish clinical applications. Join us as we lift the curtain on our two novel innovations:  achieve remarkable longevity of epithelial cells with our next-generation media featuring survival of human keratinocytes up to 90 population doublings!  create more complex organotypic 3D models of the epidermis by including melanocytes.

Discover how to take your research to new heights with CELLnTEC’s signature products:  fully defined media to minimize barriers to clinical applications and prevent late-stage failures.  precision media for developing sophisticated, reliable, and reproducible 2D/3D in vitro cell models.  specialized functional media to recapitulate the in vivo environment.  Higher Certified media to seamlessly transition from cell-based therapy development to clinical trials.

6:45 PM – 7:00 PM | Introducing the novel Electrospider series, a significant step towards the practical implementation of multiscale and multimaterial bioprinting.

Sponsor: Bio3D Printing
Speaker: Dr. Alessandro Velletri
Location: Hall 4A

Bioprinting has made remarkable progress in the fabrication of functional tissues and organ constructs, ushering in a new era of personalized medicine with applications in transplantation, drug testing, research investigation, and disease modeling. Bio3DPrinting has taken a significant step towards its clinical translation by introducing Electrospider, a bioprinting ecosystem engineered for versatile multiscale and multimaterial biofabrication. The alignment of this technology with Bio3DPrinting’s core values of flexibility, adaptability, and pursuit of state-of-the-art solutions, is evident in the development of a new product series that adheres to regulations and standard for safety and manufacturing. Pushing the boundaries of technological advancement, the incorporation of a pioneering multi-tool printhead into the novel Electrospider series marks a transformative leap forward. The novel multi-tool printhead enables synergistic use of multiple bioprinting techniques within a single printing session. This new capability, coupled with advanced management software, ensures the highest quality and safety standards in bioprinting heterogenous tissue-like constructs. Consequently, this expansion paves the way for enhanced customization and innovation in tissue engineering and allied fields.

7:05 PM – 7:20 PM | Empowering Healthcare Research with the First-Ever, Turnkey rhCollagen Bioprinting Solution

Sponsor: B9Creations
Speaker: B9Creations CEO Shon Anderson
Location: Hall 4A

Join us to learn about the breakthrough development in breast implant production using CollPlant’s human Type I collagen (rhCollagen) bioink plus B9Creations customized 3D printing platforms that has delivered parts currently undergoing large animal trials and enabling organ-on-a-chip applications. Plus discover the brand-new bio-production solution launching at TERMIS! CollPlant and B9Creations aim to revolutionize healthcare by introducing the first proven, off-the-shelf bioprinting offer combining CollPlant’s bioink and B9Creations’ printing and software toolset to enable research and bring patient-specific regenerative medicine to life. CollPlant’s plant-based bioink boasts the only commercially viable rhCollagen, which is identical to the collagen produced by the human body and does not elicit immune response that would cause implant rejection. Paired with B9Creations hardware and software additive manufacturing suite, this solution offers superior performance, consistency, safety, and ultimately better patient outcomes.

7:45 PM – 9:45 PM | Conference Reception

Location: Ballroom 6E

Join your colleagues for the 2024 Congress Reception. Appetizers and drinks will be served. This event is included in the registration fee.


Friday, June 28

Day 4: Friday, June 28

7:30 AM – 3:00 PM | Registration Desk Open

The registration desk will be located in the Atrium on the Fourth Floor of the Seattle Convention Center Arch Building.

7:30 AM – 2:00 PM | Speaker Ready Room Open

Location: Room 613

Speakers should check-in at the speaker ready room at least 2 hours prior to their session start time. Staff will be on hand to answer questions about av setup in presentation rooms and assist with any presentation edits.

8:30 AM – 10:00 AM | Scientific Concurrent Session 9
Emerging Biofabrication Technologies

Chairs: Dietmar W Hutmacher, Lucy Bosworth, Hae Lin Jang & Liqun Ning
SYIS Co-Chair: Gesine  Hentschel 
Location: Ballroom 6E
Session Topic: Cancer
Description: Biofabrication involves technologies that aim to create scaffolds for use in tissue engineering, cancer research and as structural reinforcements of constructs. Emerging technologies include, volumetric bioprinting, 4D bioprinting, and multi-materials/multimodal printing that have shown remarkable improvements experimentally in printing efficiency, accuracy, and biomimicry. Melt Electrowriting (MEW) is another high-resolution printing technology that enables the creation of highly complex scaffolds, allowing a better approximation of the natural tissue ultrastructure. Furthermore, MEW can be combined with other biofabrication techniques, such as 3D bioprinting, extrusion 3D printing, and light-based manufacturing, to create unique tissue constructs that surpass the capabilities of each individual technology. This session encompasses a broad range of applications where scaffold fabrication technologies can be employed across various tissue engineering, biofabrication, and 3D cell culture paradigms, and aims to provide a platform for knowledge exchange and fostering new collaborations to advance this important field.

Keynote Speaker:
8:30 AM 9:00 AM | The Morphological Wonderland of Melt Electrowriting
Paul Dalton, PhD

Oral Abstract Presentations:
9:00 AM 9:15 AM | 422 – Sheet-Based Extrusion Bioprinting: A New Multi-Material Paradigm With Mid-Extrusion Control Over Microchannel Patterning
Presenting Author: David Dean

9:15 AM 9:30 AM | 423 – Self-Enhancing Sono-Inks Enable Deep-Penetration Acoustic Volumetric Printing
Presenting Author: Xiao Kuang

9:30 AM 9:45 AM | 424 – 4d Bioprinting Of A Self-folding Scaffold For Trachea Engineering
Presenting Author: Carmelo De Maria

9:45 AM 10:00 AM | 425 – Additive Biomanufacturing Of Scaffold/Membrane Designs For In Vitro Skin Models
Presenting Author: Ievgenii Liashenko

Biomimetic in Vitro Models to Advance Cardiovascular Tissue Engineering

Chairs: Chris Bashur & Clotilde Castaldo
SYIS Co-Chair: Fan Zhang
Location: Room 606/607
Session Topic: Cardiovascular/Angiogenesis/Blood
Description: New devices and regenerative strategies are being developed for engineering cardiac and vascular tissues, and careful consideration of the complex cell – microenvironment interactions is necessary for these strategies to meet clinical requirements and exhibit long-term viability. Further, new in vitro models that better mimic the in vivo environment are being developed to reduce the number of animals needed for medical devices and regenerative medicine therapies. Therefore, this session will highlight both these more biomimetic in vitro models and the important scientific results obtained with these models to shed light on the orchestrated interplay between cells and matrix that guides cardiovascular tissue formation and maturation. This includes investigating the crosstalk among parenchymal cells and stromal cells, better ways to model the inflammatory response, more biomimetic matrix interactions, and interactions in both physiological and pathological conditions.

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 426 – Bone Marrow Cells Expressing CD39 Seeded Onto Tissue Engineered Vascular Grafts Inhibit Platelet-driven Thrombosis
Presenting Author: James Reinhardt

8:45 AM – 9:00 AM | 427 – Hydrogen Peroxide-releasing Hydrogels As An Injectable And Dynamic Matrix For The Treatment Of Vascular Disorders
Presenting Author: Dong Hwan Oh

9:00 AM 9:15 AM | 428 – Engineered Cocultures Of Induced Pluripotent Cell-derived Atrial Cardiomyocytes And Atrial Fibroblasts For Modeling Atrial Fibrillation
Presenting Author: Ashlin Michell

9:15 AM 9:30 AM | 429 – Mimicry Of Haemodynamic Waveforms For Vascular Bioreactors
Presenting Author: Timothy Mitchell

9:30 AM 9:45 AM | 430 – 3D In Vitro Modelling Of Human Cardiac Fibrotic Tissue Through Bio-hybrid Stretchable Scaffolds
Presenting Author: Alice Zoso

9:45 AM 10:00 AM | 431 – DEVELOPMENT OF PHOTOCROSSLINKABLE BIOINKS WITH IMPROVED ELECTROMECHANICAL PROPERTIES FOR 3D BIOPRINTING OF CARDIAC BIORINGS
Presenting Author: Houman Savoji

Strategies for Dental & Craniofacial Regeneration Session II

Chairs: Daniela Bueno & Akishigue Hokugo
SYIS Co-Chair: Mauricio Sousa
Location: Room 618/619/620
Session Topic: Dental & Craniofacial
Description:

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 432 – 3D Models Of Dental Development For Personalized Medicine And Reduction Of Diagnostic Wandering In Patients With Rare Oro-Dental Structural Disorders
Presenting Author: Varvara Gribova

8:45 AM – 9:00 AM | 433 – Crispra Based Upregulation Of Runx2 Or Sox9 Expression In Goat Bmsc For Regeneration Of The Temporomandibular Joint
Presenting Author: Joshua Stover


9:00 AM 9:15 AM | 434 – Oral-Maxillofacial Bone Regeneration Using 3D-Printed Scaffolds Loaded With Adipose Stromal Vascular Fraction
Presenting Author: Chau Sang Lau


9:15 AM 9:30 AM | 435 – RegendoGEL, a Novel Regenerative Endodontic Treatment Product for Vital Pulp Therapy
Presenting Author: Weibo Zhang


9:30 AM 9:45 AM | 436 – Stimulation Of Gingiva Self-generation Using Bio-sheets Produced During Fibrotic Encapsulation Of Mold.
Presenting Author: Kohei Shiraishi

9:45 AM 10:00 AM | Sustainably Responsive Self-adaptive Antimicrobial Peptide Hydrogel For Infected Jawbone Defect Repair
Presenting Author: Xuetao Yang

Cartilage and Osteochondral Tissue Engineering

Chairs: Chaozong Liu & Minghao Zheng
SYIS Co-Chair: Yong How Tan
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description: Osteoarthritis is a degenerative joint disease, typified by the loss in the quality of cartilage and bone at the interface of a synovial joint, resulting in pain, stiffness and reduced mobility. The current surgical treatment for advanced stages of the disease is joint replacement, where the non-surgical therapeutic options or less invasive surgical treatments are no longer effective. The objective of this symposium is (1) to discuss the current regenerative treatment options for cartilage and osteochondral (cartilage and underlying subchondral bone) defects in the articulating joints; (2) to report the scaffolds clinical requirements and performance of the currently available osteochondral scaffolds that have been investigated both in animal studies and in clinical trials; (3) to identify the main hurdles in osteochondral scaffold development for achieving satisfactory and durable regeneration of osteochondral tissues. The evolution of the osteochondral scaffolds – from monophasic to multiphasic constructs – will be included and the osteochondral scaffolds that have progressed to clinical trials will be examined with respect to their clinical performances and their potential impact on the clinical practices in this symposium.

Keynote Speaker:
8:30 AM 9:00 AM | Cell Therapy Strategies in Cartilage Repair: What Lessons Have We Learned?
Minghao Zheng, PhD, MD, FRCPA, FRCPath

Oral Abstract Presentations:
9:00 AM 9:15 AM | 438 – Engineering External Boundaries To Guide Neotissue Growth Within High Cell Density Bioinks
Presenting Author: Aliaa Karam


9:15 AM 9:30 AM | 439 – Long Term Investigation Of An Improved Strategy Of Autologous Chondrocyte Implantation With Stratified Zonal Chondrocytes Delivery For Repair Of Articular Cartilage
Presenting Author: Yingnan Wu

9:30 AM 9:45 AM | 440 – Generation Of Hypertrophic Resistant Chondrosphere From Human Ipsc For Articular Cartilage Repair
Presenting Author: Yidan Pang

9:45 AM 10:00 AM | 441 – Cartilage-penetrating And Lubricating Zwitterionic Sealant For Early-stage Osteoarthritis Treatment
Presenting Author: Maryam Asadikorayem

Engineering and Regeneration of Airway, Digestive, or UroGenital Systems

Chairs: Riccardo Gottardi & Ji Hyun Kim
SYIS Co-Chair: Jason Guo
Location: Room 611/612
Session Topic: Respiratory, Urologic & Gastrointestinal
Description: In this session, we will be discussing recent advances in the tissue engineering and regenerative medicine of the airways and of the digestive and urogenital systems, identifying key lessons that could be leveraged across structures and functions, while highlighting the unique challenges of each physiological environment.

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 442 – Mapping Lung Histological Architecture Across Fibrotic And Regenerative Trajectories Uncovers Therapeutic Cell- And Protein-Based Motifs
Presenting Author: Jason Guo

8:45 AM – 9:00 AM | 443 – Scarless Vocal Fold Regeneration By Local Delivery Of Decorin From Injectable Microgels
Presenting Author: Ryan Friedman

9:00 AM 9:15 AM | 444 – OviChip: A Next Generation In Vitro Oviduct Model
Presenting Author: Jaehyeon Kim

9:15 AM 9:30 AM | 445 – Development of a 3D Bioengineered Human Lung Airway Model for Personalized Disease Modeling
Presenting Author: Hoyeol Kim

9:30 AM 9:45 AM | 446 – Endotracheal Tube Delivered Therapeutics Modulate The Local Microbiome And Inflammatory Tissue Healing Response After Upper Airway Intubation Injury
Presenting Author: Teja Guda

9:45 AM 10:00 AM | 447 – Functional Trachea Reconstruction Using 3d-bioprinted Native-like Tissue Architecture Based On Designable Tissue-specific Bioinks
Presenting Author: Yingying Huo

Sustainable Materials in TERM

Chairs: Gulden Camci-Unal & Tram Dang
SYIS Co-Chair: Wei Qiao
Location: Room 608/609
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: Tissue engineering faces challenges in translation of biomaterials into 3D constructs that can mimic the physical, mechanical, chemical, and biological features of native tissues. Some of the traditional approaches are sophisticated and involve extensive material processing and expensive fabrication procedures. While there has been significant success in biomaterials discovery, functional and manufacturing limitations have led to the innovation of novel biomimetic materials that we can borrow from nature and human-made commodities. This session will explore tissue engineering strategies that involve unconventional biomaterials for improved scalability, sustainability, cost-efficiency, and functionality. Unconventional biomaterials are obtained from globally accessible resources and can serve across a range biomedical applications. Using non-traditional materials such as plants, silk, paper, eggshells, textiles, marine organisms, and edible products can provide unique solutions to existing challenges. With the increased use of abundant and sustainable resources, tissue engineering technologies can reach a global scale.

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 448 – Sustainable Keratin Based Templates For Term
Presenting Author: Kee Woei Ng

8:45 AM – 9:00 AM | 449 – Plant-powered Cultured Meat: Crafting A Fat Containing Hybrid Hamburger Composed Of Cell-laden Microcarriers
Presenting Author: Indi Geurs

9:00 AM 9:15 AM | 450 – Optimising The Mechanical And Immunological Properties Of Biomimetic Nanocellulosic Composite Fibres For Application As A Ligament Graft
Presenting Author: Matt Graham

9:15 AM 9:30 AM | 451 – Tunable, Light-actuated Silk Fibroin Composites For Biodevices And Term
Presenting Author: Vamsi Yadavalli

9:30 AM 9:45 AM | 452 – Recombinant Spider Silk Protein Counteracts Fibroblast-mediated Compaction Of Collagen-i Hydrogels
Presenting Author: Felix Engel

9:45 AM 10:00 AM | 453 – Multifunctional Bio-based Polyurethane Smart Mesh For Treating Stress Urinary Incontinence
Presenting Author: Amanda Artsen

Tissue Engineering Scaffolds in Regenerative Medicine

Chairs: Cecilia Giachelli & Buddy Ratner
SYIS Co-Chair: Zhipeng Deng
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: Tissue engineering scaffolds – that mimic the native extracellular matrix- play a vital role in providing an environment that facilitate cellular growth, differentiation, and maturation. Moreover, conjugating biomolecules and drugs to scaffolding materials actively influences cellular responses. However, designing clinically relevant scaffolds in a congenial and sustainable approach is still a critical engineering challenge. Moreover, we know little about how the mechanical properties of the scaffolds regulate various cellular processes such as cell division, stem cell differentiation, and cancer progression. This symposium will highlight cutting-edge advances in scaffold design to modulate cellular and biological outcomes. Efforts to explore the multifaceted challenges associated with the clinical translation and commercialization of tissue engineering scaffolds for regenerative medicine will also be featured. We invite experts worldwide to submit contributions that provide novel findings in scaffold-based tissue engineering and regenerative medicine.

Oral Abstract Presentations:
8:30 AM – 8:45 AM | 454 – Advancing Neural Regeneration Via Adaptable Hydrogels: Enriched With Mg2+</sup> And Silk Fibroin To Facilitate Endogenous Cell Infiltration And Macrophage Polarization
Presenting Author: Kunyu Zhang

8:45 AM – 9:00 AM | 455 – Matrix Architecture And Mechanics Regulate Myofibril Organization, Costamere Assembly, And Contractility Of Engineered Myocardial Microtissues
Presenting Author: Samuel DePalma

9:00 AM 9:15 AM | 456 – Activation Of PVDF-TrFE Scaffolds Direct Fibroblast And Schwann Cell Phentoype
Presenting Author: Greg Harris

9:15 AM 9:30 AM | 457 – Shape Memory Polymer Embolization Scaffolds For Treating Abdominal Aortic Aneurysms
Presenting Author: Landon Nash

9:30 AM 9:45 AM | 458 – Pre-clinical Evaluation Of A New Class III Biodegradable Stent For The Treatment Of Urethral Stricture
Presenting Author: Yurena Polo

9:45 AM 10:00 AM | 459 – Engineered Lymph Node Stromal Cell Reticula For Immunomodulation In Type 1 Diabetes
Presenting Author: Leonor Teles

Next Generation Biomaterials for Stem Cell Culture, Differentiation and therapy

Chairs: Akon Higuchi & Guoping Chen
SYIS Co-Chair: Sharun Khan
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: There is a shortage of tissues and organs for patients who suffer damage or loss of their tissues and organs. Stem cells hold promise for drug discovery and regenerative medicine. We would like to propose the symposium of “Next Generation Biomaterials for Stem Cell Culture and Differentiation for Stem Cell Therapy”. The development of a fully defined microenvironment for culturing and differentiating human stem cells will have a great effect on the use of stem cells in cell therapy and tissue engineering. In this symposium, we will discuss the design and strategy of biomaterials for stem cell culture and differentiation. Especially, we will discuss biomaterial design and preparation that can not only maintain the pluripotency and stemness of human stem cells, but also guide differentiation of stem cells (adult stem cells, fetal stem cells, human embryonic stem cells and human induced pluripotent stem cells) into specific lineages of cells (osteoblasts, chondrocytes, adipocytes, mesenchymal stem cells (from human pluripotent stem cells), hematopoietic stem cells (from human pluripotent stem cells), retinal pigment epithelium (from human pluripotent stem cells) and cardiomyocytes). We will further focus on the effects of physical cues (elasticity, micropatterning, electrical field and mechanical force), together with the biomaterials used in clinical application using stem cells and the translational development of stem cell therapies in various catastrophic illnesses.

Keynote Speaker:
8:30 AM 9:00 AM | Cultured Cell-Derived Biomimetic ECM scaffolds for Controlling Stem Cell Differentiation
Guoping Chen, Ph.D., FBSE, FRSC, FAIMBE

Oral Abstract Presentations:
9:00 AM 9:15 AM | 461 – Optimizing Hipsc-derived Spinal Cord Models By Engineering Synthetic Extracellular Matrix Microenvironments
Presenting Author: Zaida Alvarez Pinto

9:15 AM 9:30 AM | 462 – Biohybrid 3d Printing Of Electrode-interconnected Pancreatic Tissue To Stimulate And Enhance Beta Cell Functions
Presenting Author: Jihwan Kim

9:30 AM 9:45 AM | 463 – Multifunctional Agglomerates Of Mesencymal Stem Cells With Gelatin Hydrogel Beads Delivering Antibacterial Phages And/or Basic Fibroblast Growth Factor
Presenting Author: Farzaneh Moghtader

9:45 AM 10:00 AM | 464 – Electrically Conductive Biomaterials For Controlling Stem Cell Fate
Presenting Author: Amy Gelmi

Progenitor Cells for Disease Modeling and Cell Therapy

Chairs: Allison Greaney & Daniel Abebayehu
Location: Room 615/616/617
Session Topic: Stem Cell Therapies, Developmental Biology and Cell Signaling
Description: Recent advances in regenerative medicine in the respiratory, gastrointestinal, and urogenital fields have largely centered around the use of progenitor cells for direct application in vivo or through engineered tissue models. Progenitor and stem cells of primary and iPSC sources are being leveraged in cell therapy applications, to great therapeutic effect. A variety of tissue models are being developed utilizing progenitor cells for disease modeling as alternatives to traditional animal models. In some fields, such as urogenital, new models are being developed for a variety of previously understudied diseases, whereas other fields with established models, such as respiratory, are now realizing their full potential by testing myriad therapeutic interventions. This session will unify research in our respective organ systems through shared interest in the power of progenitor cells, as well as common features that contribute to model design criteria and cell-delivery considerations. Specifically, all of our systems consist of an epithelial cell barrier in contact with the external environment, which in turn closely contacts vascular and stromal cell populations, and usually possessing a robust immune component. The commonality of these design principles guide our efforts to apply cells in vivo or model these tissues ex vivo, and provides a common ground for us to unite and discuss our progress in these areas.

Keynote Speaker:
8:30 AM 9:00 AM | Immuno-stromal axes in Biomaterial-mediated Fibrosis
Daniel Abebayehu, Assistant Professor

Oral Abstract Presentations:
9:00 AM 9:15 AM | 465 – An Intestine Organotypic Model That Mimics In Vivo Villus Morphogenesis
Presenting Author: Melis Asal

9:15 AM 9:30 AM | 466 – Tip And Nontip-containing Endothelial Cell Populations Are Differentially Responsive To Angiogenic And Antiangiogenic Compounds
Presenting Author: Kara McCloskey

9:30 AM 9:45 AM | 467 – Mtor Plays An Important Role In The Stem Cell Properties Of Human Fetal Cartilage Progenitor Cells (hfcpcs)
Presenting Author: Byung Hyune Choi

9:45 AM 10:00 AM | 468 – Liver-lobule-on-chip Utilizing Ipsc-derived Hepatocytes: Development And Characterization
Presenting Author: Siiri Suominen

Meet the Editor

Chairs: Antonios Mikos
Location: Room 602/603/604
Session Topic: Special Session
Description:

Panelists:
Sophie Reisz
Catherine Kuo
Irem Bayindir-Buchhalter

10:00 AM – 10:30 AM | Networking Coffee Break

Location: Level 6 Prefunction Space

10:30 AM – 12:00 PM | Scientific Concurrent Session 10
Emerging Biofabrication Technologies – Session II

Chairs: Dietmar W. Hutmacher, Nathalie Bock & Liqun Ning
SYIS Co-Chair: Magdalena Gladysz
Location: Room 608/609
Session Topic: Biofabrication

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 469 – Magnet-mediated Biofabrication Of 3d Soft Bioscaffolds
Presenting Author: Ruoxiao Xie

10:45 AM – 11:00 AM | 470 – 4d Printed Magnetically Aligned Collagen Scaffolds For Ligamentous Applications
Presenting Author: Nashaita Patrawalla

11:00 AM – 11:15 AM | 471 – Fabrication Of Microstructured Multi-material Tissues Using Chaotic Advection: Chaotic Bioprinting
Presenting Author: Grissel Trujillo de Santiago

11:15 AM – 11:30 AM | 472 – Boosting Volumetric 3D Robotic Printing Applications Through A Universal Hardware/Software Synchronization Platform
Presenting Author: Pierpaolo Fucile

11:30 AM – 11:45 AM | 473 – 3D Adipose Tissue Model With Tunable Fat Content Consisting Of Multicellular Spheroids Seeded Into Melt Electrowriting (MEW) Scaffolds
Presenting Author: Franziska Dusi

11:45 AM – 12:00 PM | 474 – 3d Printing Functional Human Intestinal Villi And Crypts With Enhanced Cell Adhesion To Gelatin Methacryloyl Hydrogels Using Biological Enzyme Coating
Presenting Author: Lindy Jang

Models for Investigating Therapeutic Approaches for Cancer

Chairs: Daniel Harrington & Ana Maria Porras
SYIS Co-Chair: Sara Micheli
Location: Room 615/616/617
Session Topic: Cancer
Description: This session will feature advances in engineered tumor models for testing cancer therapeutics, including organoid-based cultures and microfluidic-based platforms. Emphasis will be placed on models that recapitulate different aspects of the tumor microenvironment for the assessment of drugs.

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 475 – Design Of Bioengineered Glioblastoma Microenvironment Models For The Validation Of Innovative Nanomedicines
Presenting Author: Andrea Bezze

10:45 AM – 11:00 AM | 476 – Integrated Microfluidic Blood Brain Barrier Chip And 3D Glioblastoma Spheroids For Systemic Delivery Of Oncolytic HSV-1 Autologous Monocytes
Presenting Author: Sara Micheli

11:00 AM – 11:15 AM | 477 – Synthetic Bone Marrow Niches For Testing Novel Leukaemia Therapies
Presenting Author: William Doherty-Boyd

11:15 AM – 11:30 AM | 478 – A Gravity-driven Tissue Chip To Study Efficacy And Toxicity Of Cancer Drugs
Presenting Author: Hossein Tavana

11:30 AM – 11:45 AM | 479 – Evaluating The Efficacy Of Targeted Vs Non-targeted Dox Nanoparticles In Treating Triple Negative Breast Cancer Bone Metastases In A Humanized Mouse Model
Presenting Author: Jacqui Mcgovern

11:45 AM – 12:00 PM | 480 – A Systematic Comparative Evaluation Of The Therapeutic Efficiency Of Novel Proton Beam And Conventional Photon Therapies On Advanced Multicellular 3D Pancreatic Cancer Models
Presenting Author: Eirini Velliou

Cartilage and Osteochondral Tissue Engineering – Session II

Chairs: J. Miguel Oliveira & Chaozong Liu
SYIS Co-Chair: Brian O’Grady
Location: Ballroom 6C
Session Topic: Musculoskeletal
Description: Osteoarthritis is a degenerative joint disease, typified by the loss in the quality of cartilage and bone at the interface of a synovial joint, resulting in pain, stiffness and reduced mobility. The current surgical treatment for advanced stages of the disease is joint replacement, where the non-surgical therapeutic options or less invasive surgical treatments are no longer effective. The objective of this symposium is (1) to discuss the current regenerative treatment options for cartilage and osteochondral (cartilage and underlying subchondral bone) defects in the articulating joints; (2) to report the scaffolds clinical requirements and performance of the currently available osteochondral scaffolds that have been investigated both in animal studies and in clinical trials; (3) to identify the main hurdles in osteochondral scaffold development for achieving satisfactory and durable regeneration of osteochondral tissues. The evolution of the osteochondral scaffolds – from monophasic to multiphasic constructs – will be included and the osteochondral scaffolds that have progressed to clinical trials will be examined with respect to their clinical performances and their potential impact on the clinical practices in this symposium.

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 481 – Mechanical Stable Fixation Of Osteochondral Scaffold Enhanced Overlying Cartilage Regeneration: In Vivo Sheep Condyle Model Study
Presenting Author: Chaozong Liu

10:45 AM – 11:00 AM | 482 – A Multi-layered Mechanically Reinforced Collagen-based Scaffold Promotes Repair Of Critical Sized Articular Joint Defects In Both Young And Elderly Goats
Presenting Author: Claudio Intini

11:00 AM – 11:15 AM | 483 – A Novel Injectable Hydrogel-based Drug Delivery System For The Repair Of Cartilage Defects
Presenting Author: Arjan Atwal

11:15 AM – 11:30 AM | 484 – The Neuropeptide CGRP Impairs Chondrocyte Mechano-adaptation In Tissue-engineered Cartilage
Presenting Author: Helen Dietmar

11:30 AM – 11:45 AM | 485 – A Multifactorial Joint-on-a-chip Device For Inflammatory And Mechanical Disease Modelling Of Osteoarthritis
Presenting Author: Kevin Perera

11:45 AM – 12:00 PM | 486 – Integrating Crispr And Machine Learning To Achieve Mature Chondrocyte Genetic Profiles In Mscs
Presenting Author: Joshua Graham

Ophthalmic Tissue Regeneration and Bioengineering

Chairs: Jingjing You & Khoon Lim
SYIS Co-Chair: Marcelo Muñoz Figueroa
Location: Room 618/619/620
Session Topic: Ophthamologic
Description: The human eye consists of tissues that have distinct and unique properties that are different from other human tissues. For example, the cornea and lens are the only transparent tissues in our body, while the retina, being a thin layer, consists of one of the most complex networks of neurons and non-neuronal cells. A wide spectrum of modern bioengineering techniques has been researched and developed to reconstruct/regenerate these unique ophthalmologic tissues. These techniques include using electronic stimulus for neuron regeneration in the retina, developing new transparent biomaterials and scaffolds for corneal transplantation, employing in-situ printing for ocular wound healing, utilizing microfluidic technologies for drug delivery and organ-on-chip models, and exploring technologies for the reconstruction of the entire eye. This session focuses on showcasing emerging technologies applied to overcome challenging questions faced in ophthalmologic research and clinical applications. These challenges include corneal transplantation, treating retinal degeneration, developing new drug/cell delivery methods for ocular diseases, and many more.

Keynote Speaker:
10:30 AM – 11:00 AM | Bioengineering Strategies for Optic Nerve Regeneration
Dong Feng Chen

Oral Abstract Presentations:
11:00 AM – 11:15 AM | 487 – Development Of Photosensitive Device Based On Conjugated Polymer Nanoparticles For An Application In Future Artificial Retinas
Presenting Author: Marcin Gwiazda

11:15 AM – 11:30 AM | 488 – 3d Bioprinting Of Dual-layered Corneal Stromal And Endothelium Using Transparent Collagen-based Bioinks
Presenting Author: Huasheng (Sheng) Huang

11:30 AM – 11:45 AM | 489 – Laminin Based Hydrogels To Deliver IPSC Derived Choroidal Endothelial Cells For The Treatment Of AMD
Presenting Author: Narendra Pandala

11:45 AM – 12:00 PM | 490 – Macromolecular Crowding In The Development Of Human Corneal Stromal Assemblies
Presenting Author: Dimitrios Zevgolis

Bioassembly and Formation of Spheroids and Organoids for Tissue Engineering

Chairs: Julia Fernández Pérez & Jose Granjeiro
SYIS Co-Chair: Dariya Lizanets
Location: Room 611/612
Session Topic: Organoids, Bioreactors & Organ-on-Chip
Description: Biofabrication of human organs is still a challenge spite of recent advances in bioprinting approaches. In tissue engineering, the classical approach includes cell suspension seeded onto or into scaffolds, however, the organ microarchitecture is not reproduced. In this context the use of spheroids and organoids emerges. The start-of-art is based on the intrinsic capacity of spheroids and organoids to fuse (building blocks) resulting in organ microarchitecture. The proposal of this session is to bring the light recent studies about self-assembly and maturation of spheroids and organoids and biofabrication approaches to assembly these building blocks (fusion) including the development of bioinks and vascularization units.

Keynote Speaker:
10:30 AM – 11:00 AM | Kenzan method for clinical application
Koichi Nakayama, M.D., Ph.D

Oral Abstract Presentations:
11:00 AM – 11:15 AM | 491 – Bioprinting Of Human Liver Tissues With Endothelial Microvessels For Regenerative Medicine
Presenting Author: Kerry Rogy

11:15 AM – 11:30 AM | 492 – HiPSC-derived Vascularized And Myogenic Spheroids For Skeletal Muscle Tissue Engineering
Presenting Author: Jasper Smet

11:30 AM – 11:45 AM | 493 – Fabrication Of Neurovascular Organoids In Microdevices
Presenting Author: Tomoki Asaba

11:45 AM – 12:00 PM | 494 – Scaffolded Spheroids: High-Resolution 3D-printed Microscaffolds Offer New Approaches To Overcome Spheroid-Based Tissue Engineering Limitations
Presenting Author: Oliver Kopinski-Grünwald

Bridging Gene Therapies and Implants for Tissue Repair: Gene-activated Scaffolds in Regenerative Medicine

Chairs: Fergal O’Brien & Joanna Sadowska
SYIS Co-Chair: Marrisa Therriault 
Location: Ballroom 6A
Session Topic: Scaffolds, Matrices, and Biomaterials
Description: The challenges of regenerative medicine, such as the repair of complex tissues following disease or degeneration, require innovative solutions. This symposium aims to shed light on a growing approach for complex conditions, which combines gene therapies and biomaterial scaffolds. Gene-activated scaffolds, designed with the capacity for local, targeted delivery of genetic cargoes (including mRNA, microRNA, or pDNA), offer a potential revolutionary strategy to enhance tissue repair. Unlike growth factors and recombinant proteins, these scaffolds do not require supraphysiological dosages, as, if designed appropriately, the scaffolds can act as reservoirs for the nanomedicine, reducing the risk of adverse effects and enhancing the regenerative capacity of the scaffold. By attending this symposium, participants will: • Gain an overview of the current state-of-the-art solutions and challenges in the development of gene-activated scaffolds. • Deepen their knowledge of the differences between various specific cargoes (e.g., mRNA vs. microRNA) as well as various delivery systems (e.g., viral vs. non-viral). • Learn about the future prospects of gene-activated scaffold technology and how these advancements are being translated into clinical practice.

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 495 – Inhibition Of MicroRNA-182-5p And MicroRNA-200b-3p Using Collagen-nanohydroxyapatite Scaffolds For The Healing Of Large Volume Bone Defects
Presenting Author: Caroline Curtin

10:45 AM – 11:00 AM | 496 – Development Of Mir-26a-activated Scaffold To Promote Healing Of The Long Bone Defects Through Angiogenic And Osteogenic Pathways
Presenting Author: Joanna Sadowska

11:00 AM – 11:15 AM | 497 – Scaffold-mediated Mir-219/mir-338 Promotes Oligodendrocyte Progenitor Cells Differentiation And Remyelination, Facilitating Functional Recovery Following Spinal Cord Injury
Presenting Author: Wei Ju

11:15 AM – 11:30 AM | 498 – Non-viral Gene Delivery Using Engineered Extracellular Vesicles To Reprogram Human Annulus Fibrosus Cells On 3d Matrices Mimicking Health And Disease
Presenting Author: Justin Richards

11:30 AM – 11:45 AM | 499 – A Gene-activated Injectable And 3D Printable Hyaluronic Acid And Collagen Type II-based Hydrogel For Articular Cartilage Repair
Presenting Author: Claudio Intini

11:45 AM – 12:00 PM | 500 – Development Of A MicroRNA-155-activated Collagen-GAG Scaffold For Anti-inflammatory And Pro-angiogenic Outcomes In Wound Healing
Presenting Author: Juan Palomeque Chávez

Tissue Engineering Scaffolds in Regenerative Medicine – Session II

Chairs: Janet Zoldan & Willeke Daamen
SYIS Co-Chair: Priyanka  Desai
Location: Ballroom 6B
Session Topic: Scaffolds, Matrices, and Biomaterials
Description:

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 501 – Biomimetic 3DPrinted Scaffolds As An Alternative Of Autograft For The Treatment Of Large Osteochondral Defects In An Adolescent Porcine Model: Outcomes At 6 Months
Presenting Author: Sanjoy Kumar Ghorai

10:45 AM – 11:00 AM | 502 – Regeneration Of Large Segmental Bone Defects In Sheep Treated With 3d Printed Scaffolds And Autologous Adipose Derived Stem Cells
Presenting Author: David Margolis

11:00 AM – 11:15 AM | 503 – Targeting Bone Defect Repair With A Novel And Biodegradable Borophene-Monetite Implant
Presenting Author: Justin Matta

11:15 AM – 11:30 AM | 504 – Fabrication Of Scaffolds With Complex Hierarchical Compositions For Mechano-instructive Osteochondral Regeneration
Presenting Author: Tim Brink

11:30 AM – 11:45 AM | 505 – Photothermal Regulation Of Osteoimmune Microenvironment Through Pi3k/akt Pathway For Infectious Bone Defect Repair
Presenting Author: Xiangru Chen

11:45 AM – 12:00 PM | 506 – An Engineered Model Of The Human Liver Containing Both Hepatocytes And Branching Biliary Ducts
Presenting Author: Ashlin Michell

Extracellular Vesicles in TERM – Session II

Chairs: Antonio Salgado & Johannes Grillari
SYIS Co-Chair: Ronja Finze
Location: Room 606/607
Session Topic: Stem Cell Therapies, Developmental Biology and Cell Signaling
Description: In recent years there has been a significative effort to develop disease or injury disease modifying strategies that go beyond from the pharmaco-therapies and cell/organ transplantation methodologies that are currently considered to be the state of the art. In recent years, cells secretome has been demonstrating to play an important role in regulating key processes within human tissues. Indeed, since 1998, the body of literature on these topics has grown exponentially. Over this period, cells secretome has shown to be responsible for the regulation of cell survival, proliferation and differentiation, tumor growth and invasiveness, as well as a path for communication between the periphery and the central nervous system. Due to this increased attention to their role and impact on personalized and regenerative medicine strategies, we believe that it is timely to organize a symposium fully dedicated to this topic, with a particular focus on: 1) Pre-clinical and clinical applications of secretome based therapies 2) Secretome mediated cell interactions in injury, degeneration and repair 3) Development of biomaterial-secretome based approaches in repair and regeneration 4) Strategies that modulate cell secretome to impact their application in regenerative medicine 5) Secretome as a source of biomarkers in personalized and regenerative medicine 6) Proteomic, metabolomic, and lipidomic characterization of the secretome

Oral Abstract Presentations:
10:30 AM – 10:45 AM | 507 – Engineered Skeletal Muscle-Derived Extracellular Vesicles And Their Impact On Glucose Regulation In Type 2 Diabetes
Presenting Author: Hagit Shoychet

10:45 AM – 11:00 AM | 508 – Exosomes Loaded With Silver Nanoparticle Facilitate Diabetic Wound Healing Through Improving Fibroblasts And Endothelial Cells Function And Activating Macrophages Autophagy
Presenting Author: Yi Yi

11:00 AM – 11:15 AM | 509 – Honeybee Extracellular Vesicles For Complex Wound Healing Approaches
Presenting Author: Christina Schuh

11:15 AM – 11:30 AM | 510 – Comparative Therapeutic Efficacy Of Evs From Perinatal Evs, Fetal Mscs And Fetal Chondrocytes On Inflamed Articular Chondrocytes
Presenting Author: Florien Jenner

11:30 AM – 11:45 AM | 511 – Integrative Transcriptomic-proteomic Analysis Of Primary Human Fetal, Adult Dermal And Eschar Mesenchymal Cells And Their Secreted Extracellular Matrices
Presenting Author: Madalena Gomes

11:45 AM – 12:00 PM | 512 – Using Automated Patch Clamp For High Throughput Characterization Of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes Cultured Either In Two Or Three-dimensions.
Presenting Author: Daniel Sauter

Advanced Biomaterial Design in TERM

Chairs: Ngan Huang & Ishita Jain
Location: Room 602/603/604

Oral Abstract Presentations:
10:30 AM – 10:45 AM | Evaluation Of Bi-layer Silk Fibroin Grafts For Onlay Urethroplasty In A Female Porcine Model Of Long Urethral Strictures
Presenting Author: Gokhan Gundogdu

10:45 AM – 11:00 AM | Rational Protein Design Identifies PDGF- And VEGF-Specific Protein Binders For Tunable Affinity-Controlled Protein Delivery
Presenting Author: Justin Svendsen

11:00 AM – 11:15 AM | Engineered Matrices Reveal Stiffness-mediated Chemoresistance In Patient-derived Pancreatic Cancer Organoids Through Hyaluronan-CD44 Interactions
Presenting Author: Carla Huerta-Lopez

11:15 AM – 11:30 AM
Presenting Author:

11:30 AM – 11:45 AM | Design And Fabrication Of A Bioresorbable, Electrically Conductive And Mechanically Compliant Cardiac Patch
Presenting Author: Xinlong Wang

11:45 AM – 12:00 PM | Multifunctional And User-Friendly Hydrogel For Treatment Of Hemorrhage In Soft Tissue Trauma
Presenting Author: Saumya Jain

12:00 PM – 1:30 PM | Lunch on Your Own

Enjoy lunch at one of the many restaurants located in and around the convention center.

12:00 PM – 1:30 PM | Global Networking Luncheon: Building TERMIS Communities Around the World (ticketed event)

Location: Ballroom 6E

Come and join us for networking and discussions about building Global TERMIS communities. Our guest speakers Ana Maria Porras and Brian Aguado will share their experience of developing the LatinXinBME  community. We will follow this presentation with table discussions of social networking tools to enable building global communities to support career growth and development.

Chair: Lisa White
Keynote Speakers:
Ana Maria Porras, TERMIS-AM
Brian Aguado, TERMIS-AM

Panelists:
Lisa White, TERMIS-EU
Karina Nakayama, TERMIS-AM
Julia Fernández Pérez, TERMIS-EU
Sing Yian Chew, TERMIS-AP
Paul Wieringa, TERMIS-EU
Helen Lu, TERMIS-AM 
Catherine Le Visage, TERMIS-EU
Jinah Park, TERMIS-AP
Jelena Rnjak-Kovacina, TERMIS-AP
Tim Woodfield, TERMIS-AP

1:30 PM – 3:00 PM | Plenary Session 3, President’s Transition & AM Chapter Awards

Location: Ballroom 6 B/C

1:30 PM – 2:30 PM | Philosophy and Ethics in TERM Panel Discussion
Moderators: Maria Hudock & Sheng Huang
Panelists:
Guoping Chen
Tony Mikos
Molly S Shoichet
Ece Öztürk

2:30 PM – 3:00 PM | President’s Transition & Americas Chapter Awards